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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-185294982-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=185294982&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 185294982,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001378032.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "NM_001378034.2",
"protein_id": "NP_001364963.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1004,
"cds_start": null,
"cds_end": null,
"cds_length": 3015,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000652585.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378034.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000652585.2",
"protein_id": "ENSP00000498676.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1004,
"cds_start": null,
"cds_end": null,
"cds_length": 3015,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001378034.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000652585.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.670+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000504273.5",
"protein_id": "ENSP00000426255.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 840,
"cds_start": null,
"cds_end": null,
"cds_length": 2523,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000504273.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1261+6900A>T",
"hgvs_p": null,
"transcript": "NM_001378032.2",
"protein_id": "NP_001364961.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1037,
"cds_start": null,
"cds_end": null,
"cds_length": 3114,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378032.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000927314.1",
"protein_id": "ENSP00000597373.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1016,
"cds_start": null,
"cds_end": null,
"cds_length": 3051,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927314.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000862627.1",
"protein_id": "ENSP00000532686.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1015,
"cds_start": null,
"cds_end": null,
"cds_length": 3048,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862627.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000968206.1",
"protein_id": "ENSP00000638265.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1003,
"cds_start": null,
"cds_end": null,
"cds_length": 3012,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968206.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000968211.1",
"protein_id": "ENSP00000638270.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 995,
"cds_start": null,
"cds_end": null,
"cds_length": 2988,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968211.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "NM_001423234.1",
"protein_id": "NP_001410163.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 992,
"cds_start": null,
"cds_end": null,
"cds_length": 2979,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001423234.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000968209.1",
"protein_id": "ENSP00000638268.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 972,
"cds_start": null,
"cds_end": null,
"cds_length": 2919,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968209.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "NM_001378036.2",
"protein_id": "NP_001364965.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 970,
"cds_start": null,
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"cds_length": 2913,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378036.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000927310.1",
"protein_id": "ENSP00000597369.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 960,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000927310.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000927313.1",
"protein_id": "ENSP00000597372.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000927313.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 18,
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"gene_symbol": "SNX25",
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"hgvs_c": "c.1162+6900A>T",
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"transcript": "NM_001378035.2",
"protein_id": "NP_001364964.1",
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"biotype": "protein_coding",
"feature": "NM_001378035.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000862628.1",
"protein_id": "ENSP00000532687.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000862628.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 6,
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"gene_symbol": "SNX25",
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"hgvs_c": "c.1162+6900A>T",
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"biotype": "protein_coding",
"feature": "ENST00000927309.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1261+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000927308.1",
"protein_id": "ENSP00000597367.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000927308.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000927311.1",
"protein_id": "ENSP00000597370.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
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"hgvs_c": "c.1162+6900A>T",
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"transcript": "NM_001378037.2",
"protein_id": "NP_001364966.1",
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"feature": "NM_001378037.2"
},
{
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"protein_coding": true,
"strand": true,
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"intron_variant"
],
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"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000968210.1",
"protein_id": "ENSP00000638269.1",
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968210.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SNX25",
"gene_hgnc_id": 21883,
"hgvs_c": "c.1162+6900A>T",
"hgvs_p": null,
"transcript": "ENST00000968207.1",
"protein_id": "ENSP00000638266.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 894,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968207.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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}