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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-2829995-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=2829995&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 2829995,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001145856.2",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "NM_001122681.2",
"protein_id": "NP_001116153.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1147,
"cdna_end": null,
"cdna_length": 9006,
"mane_select": "ENST00000503393.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001122681.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000503393.8",
"protein_id": "ENSP00000422168.3",
"transcript_support_level": 1,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1147,
"cdna_end": null,
"cdna_length": 9006,
"mane_select": "NM_001122681.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000503393.8"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1260T>C",
"hgvs_p": "p.Ala420Ala",
"transcript": "ENST00000511747.6",
"protein_id": "ENSP00000424846.2",
"transcript_support_level": 1,
"aa_start": 420,
"aa_end": null,
"aa_length": 618,
"cds_start": 1260,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 1299,
"cdna_end": null,
"cdna_length": 2351,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000511747.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "n.1350T>C",
"hgvs_p": null,
"transcript": "ENST00000356331.10",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9211,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000356331.10"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1260T>C",
"hgvs_p": "p.Ala420Ala",
"transcript": "NM_001145856.2",
"protein_id": "NP_001139328.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 618,
"cds_start": 1260,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 1314,
"cdna_end": null,
"cdna_length": 9173,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145856.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1260T>C",
"hgvs_p": "p.Ala420Ala",
"transcript": "ENST00000932791.1",
"protein_id": "ENSP00000602850.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 618,
"cds_start": 1260,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 1483,
"cdna_end": null,
"cdna_length": 5285,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932791.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1173T>C",
"hgvs_p": "p.Ala391Ala",
"transcript": "NM_001145855.2",
"protein_id": "NP_001139327.1",
"transcript_support_level": null,
"aa_start": 391,
"aa_end": null,
"aa_length": 589,
"cds_start": 1173,
"cds_end": null,
"cds_length": 1770,
"cdna_start": 1280,
"cdna_end": null,
"cdna_length": 9139,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145855.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1173T>C",
"hgvs_p": "p.Ala391Ala",
"transcript": "ENST00000435136.8",
"protein_id": "ENSP00000403231.3",
"transcript_support_level": 2,
"aa_start": 391,
"aa_end": null,
"aa_length": 589,
"cds_start": 1173,
"cds_end": null,
"cds_length": 1770,
"cdna_start": 1280,
"cdna_end": null,
"cdna_length": 9139,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000435136.8"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893561.1",
"protein_id": "ENSP00000563620.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 573,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1722,
"cdna_start": 1147,
"cdna_end": null,
"cdna_length": 2232,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893561.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "NM_003023.4",
"protein_id": "NP_003014.3",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1350,
"cdna_end": null,
"cdna_length": 9209,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003023.4"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000502260.6",
"protein_id": "ENSP00000425537.2",
"transcript_support_level": 3,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1388,
"cdna_end": null,
"cdna_length": 9247,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000502260.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000503219.7",
"protein_id": "ENSP00000422796.2",
"transcript_support_level": 4,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1212,
"cdna_end": null,
"cdna_length": 9073,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000503219.7"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000504294.6",
"protein_id": "ENSP00000423275.2",
"transcript_support_level": 5,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1129,
"cdna_end": null,
"cdna_length": 8988,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000504294.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000508385.6",
"protein_id": "ENSP00000424917.2",
"transcript_support_level": 3,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1401,
"cdna_end": null,
"cdna_length": 9260,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000508385.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000512014.6",
"protein_id": "ENSP00000424105.2",
"transcript_support_level": 3,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1195,
"cdna_end": null,
"cdna_length": 9054,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000512014.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000513095.6",
"protein_id": "ENSP00000423823.2",
"transcript_support_level": 4,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1288,
"cdna_end": null,
"cdna_length": 9147,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000513095.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893545.1",
"protein_id": "ENSP00000563604.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1337,
"cdna_end": null,
"cdna_length": 5138,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893545.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893546.1",
"protein_id": "ENSP00000563605.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1305,
"cdna_end": null,
"cdna_length": 2361,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893546.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893548.1",
"protein_id": "ENSP00000563607.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1590,
"cdna_end": null,
"cdna_length": 2642,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893548.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893549.1",
"protein_id": "ENSP00000563608.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1293,
"cdna_end": null,
"cdna_length": 2350,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893549.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893550.1",
"protein_id": "ENSP00000563609.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
"cds_length": 1686,
"cdna_start": 1502,
"cdna_end": null,
"cdna_length": 2554,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893550.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SH3BP2",
"gene_hgnc_id": 10825,
"hgvs_c": "c.1089T>C",
"hgvs_p": "p.Ala363Ala",
"transcript": "ENST00000893551.1",
"protein_id": "ENSP00000563610.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 561,
"cds_start": 1089,
"cds_end": null,
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}
],
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}