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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-38137235-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=38137235&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 38137235,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001396959.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3689G>C",
"hgvs_p": "p.Arg1230Pro",
"transcript": "NM_001396959.1",
"protein_id": "NP_001383888.1",
"transcript_support_level": null,
"aa_start": 1230,
"aa_end": null,
"aa_length": 1262,
"cds_start": 3689,
"cds_end": null,
"cds_length": 3789,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000698857.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001396959.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3689G>C",
"hgvs_p": "p.Arg1230Pro",
"transcript": "ENST00000698857.1",
"protein_id": "ENSP00000513987.1",
"transcript_support_level": null,
"aa_start": 1230,
"aa_end": null,
"aa_length": 1262,
"cds_start": 3689,
"cds_end": null,
"cds_length": 3789,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001396959.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000698857.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3407G>C",
"hgvs_p": "p.Arg1136Pro",
"transcript": "ENST00000261439.9",
"protein_id": "ENSP00000261439.4",
"transcript_support_level": 1,
"aa_start": 1136,
"aa_end": null,
"aa_length": 1168,
"cds_start": 3407,
"cds_end": null,
"cds_length": 3507,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000261439.9"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3728G>C",
"hgvs_p": "p.Arg1243Pro",
"transcript": "ENST00000961338.1",
"protein_id": "ENSP00000631397.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1275,
"cds_start": 3728,
"cds_end": null,
"cds_length": 3828,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961338.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3710G>C",
"hgvs_p": "p.Arg1237Pro",
"transcript": "ENST00000859648.1",
"protein_id": "ENSP00000529707.1",
"transcript_support_level": null,
"aa_start": 1237,
"aa_end": null,
"aa_length": 1269,
"cds_start": 3710,
"cds_end": null,
"cds_length": 3810,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859648.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3650G>C",
"hgvs_p": "p.Arg1217Pro",
"transcript": "ENST00000859644.1",
"protein_id": "ENSP00000529703.1",
"transcript_support_level": null,
"aa_start": 1217,
"aa_end": null,
"aa_length": 1249,
"cds_start": 3650,
"cds_end": null,
"cds_length": 3750,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859644.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3599G>C",
"hgvs_p": "p.Arg1200Pro",
"transcript": "ENST00000859649.1",
"protein_id": "ENSP00000529708.1",
"transcript_support_level": null,
"aa_start": 1200,
"aa_end": null,
"aa_length": 1232,
"cds_start": 3599,
"cds_end": null,
"cds_length": 3699,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859649.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3578G>C",
"hgvs_p": "p.Arg1193Pro",
"transcript": "ENST00000961343.1",
"protein_id": "ENSP00000631402.1",
"transcript_support_level": null,
"aa_start": 1193,
"aa_end": null,
"aa_length": 1225,
"cds_start": 3578,
"cds_end": null,
"cds_length": 3678,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961343.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3566G>C",
"hgvs_p": "p.Arg1189Pro",
"transcript": "ENST00000961337.1",
"protein_id": "ENSP00000631396.1",
"transcript_support_level": null,
"aa_start": 1189,
"aa_end": null,
"aa_length": 1221,
"cds_start": 3566,
"cds_end": null,
"cds_length": 3666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961337.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3560G>C",
"hgvs_p": "p.Arg1187Pro",
"transcript": "ENST00000859650.1",
"protein_id": "ENSP00000529709.1",
"transcript_support_level": null,
"aa_start": 1187,
"aa_end": null,
"aa_length": 1219,
"cds_start": 3560,
"cds_end": null,
"cds_length": 3660,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859650.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3530G>C",
"hgvs_p": "p.Arg1177Pro",
"transcript": "ENST00000936241.1",
"protein_id": "ENSP00000606300.1",
"transcript_support_level": null,
"aa_start": 1177,
"aa_end": null,
"aa_length": 1209,
"cds_start": 3530,
"cds_end": null,
"cds_length": 3630,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936241.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3488G>C",
"hgvs_p": "p.Arg1163Pro",
"transcript": "ENST00000859647.1",
"protein_id": "ENSP00000529706.1",
"transcript_support_level": null,
"aa_start": 1163,
"aa_end": null,
"aa_length": 1195,
"cds_start": 3488,
"cds_end": null,
"cds_length": 3588,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859647.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3473G>C",
"hgvs_p": "p.Arg1158Pro",
"transcript": "ENST00000961340.1",
"protein_id": "ENSP00000631399.1",
"transcript_support_level": null,
"aa_start": 1158,
"aa_end": null,
"aa_length": 1190,
"cds_start": 3473,
"cds_end": null,
"cds_length": 3573,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961340.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3467G>C",
"hgvs_p": "p.Arg1156Pro",
"transcript": "ENST00000859651.1",
"protein_id": "ENSP00000529710.1",
"transcript_support_level": null,
"aa_start": 1156,
"aa_end": null,
"aa_length": 1188,
"cds_start": 3467,
"cds_end": null,
"cds_length": 3567,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859651.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3407G>C",
"hgvs_p": "p.Arg1136Pro",
"transcript": "NM_015173.4",
"protein_id": "NP_055988.2",
"transcript_support_level": null,
"aa_start": 1136,
"aa_end": null,
"aa_length": 1168,
"cds_start": 3407,
"cds_end": null,
"cds_length": 3507,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015173.4"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3380G>C",
"hgvs_p": "p.Arg1127Pro",
"transcript": "NM_001253912.2",
"protein_id": "NP_001240841.1",
"transcript_support_level": null,
"aa_start": 1127,
"aa_end": null,
"aa_length": 1159,
"cds_start": 3380,
"cds_end": null,
"cds_length": 3480,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001253912.2"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3380G>C",
"hgvs_p": "p.Arg1127Pro",
"transcript": "ENST00000508802.5",
"protein_id": "ENSP00000423651.1",
"transcript_support_level": 2,
"aa_start": 1127,
"aa_end": null,
"aa_length": 1159,
"cds_start": 3380,
"cds_end": null,
"cds_length": 3480,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000508802.5"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3368G>C",
"hgvs_p": "p.Arg1123Pro",
"transcript": "ENST00000859645.1",
"protein_id": "ENSP00000529704.1",
"transcript_support_level": null,
"aa_start": 1123,
"aa_end": null,
"aa_length": 1155,
"cds_start": 3368,
"cds_end": null,
"cds_length": 3468,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859645.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3296G>C",
"hgvs_p": "p.Arg1099Pro",
"transcript": "ENST00000936240.1",
"protein_id": "ENSP00000606299.1",
"transcript_support_level": null,
"aa_start": 1099,
"aa_end": null,
"aa_length": 1131,
"cds_start": 3296,
"cds_end": null,
"cds_length": 3396,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936240.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3284G>C",
"hgvs_p": "p.Arg1095Pro",
"transcript": "ENST00000961339.1",
"protein_id": "ENSP00000631398.1",
"transcript_support_level": null,
"aa_start": 1095,
"aa_end": null,
"aa_length": 1127,
"cds_start": 3284,
"cds_end": null,
"cds_length": 3384,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961339.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3245G>C",
"hgvs_p": "p.Arg1082Pro",
"transcript": "ENST00000961341.1",
"protein_id": "ENSP00000631400.1",
"transcript_support_level": null,
"aa_start": 1082,
"aa_end": null,
"aa_length": 1114,
"cds_start": 3245,
"cds_end": null,
"cds_length": 3345,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961341.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TBC1D1",
"gene_hgnc_id": 11578,
"hgvs_c": "c.3083G>C",
"hgvs_p": "p.Arg1028Pro",
"transcript": "ENST00000961342.1",
"protein_id": "ENSP00000631401.1",
"transcript_support_level": null,
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}
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}