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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-39086721-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=39086721&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 39086721,
"ref": "A",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "ENST00000504108.7",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1107A>C",
"hgvs_p": "p.Ala369Ala",
"transcript": "NM_015990.5",
"protein_id": "NP_057074.4",
"transcript_support_level": null,
"aa_start": 369,
"aa_end": null,
"aa_length": 709,
"cds_start": 1107,
"cds_end": null,
"cds_length": 2130,
"cdna_start": 1528,
"cdna_end": null,
"cdna_length": 7718,
"mane_select": "ENST00000504108.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1107A>C",
"hgvs_p": "p.Ala369Ala",
"transcript": "ENST00000504108.7",
"protein_id": "ENSP00000423897.2",
"transcript_support_level": 2,
"aa_start": 369,
"aa_end": null,
"aa_length": 709,
"cds_start": 1107,
"cds_end": null,
"cds_length": 2130,
"cdna_start": 1528,
"cdna_end": null,
"cdna_length": 7718,
"mane_select": "NM_015990.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1107A>C",
"hgvs_p": "p.Ala369Ala",
"transcript": "ENST00000381930.8",
"protein_id": "ENSP00000371355.4",
"transcript_support_level": 1,
"aa_start": 369,
"aa_end": null,
"aa_length": 711,
"cds_start": 1107,
"cds_end": null,
"cds_length": 2136,
"cdna_start": 1320,
"cdna_end": null,
"cdna_length": 3288,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1107A>C",
"hgvs_p": "p.Ala369Ala",
"transcript": "ENST00000261425.7",
"protein_id": "ENSP00000261425.3",
"transcript_support_level": 1,
"aa_start": 369,
"aa_end": null,
"aa_length": 709,
"cds_start": 1107,
"cds_end": null,
"cds_length": 2130,
"cdna_start": 1259,
"cdna_end": null,
"cdna_length": 3425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.924A>C",
"hgvs_p": "p.Ala308Ala",
"transcript": "ENST00000261426.10",
"protein_id": "ENSP00000261426.6",
"transcript_support_level": 1,
"aa_start": 308,
"aa_end": null,
"aa_length": 648,
"cds_start": 924,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1137,
"cdna_end": null,
"cdna_length": 3300,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.684A>C",
"hgvs_p": "p.Ala228Ala",
"transcript": "ENST00000508137.6",
"protein_id": "ENSP00000423080.2",
"transcript_support_level": 1,
"aa_start": 228,
"aa_end": null,
"aa_length": 568,
"cds_start": 684,
"cds_end": null,
"cds_length": 1707,
"cdna_start": 761,
"cdna_end": null,
"cdna_length": 2926,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1107A>C",
"hgvs_p": "p.Ala369Ala",
"transcript": "NM_001007075.2",
"protein_id": "NP_001007076.1",
"transcript_support_level": null,
"aa_start": 369,
"aa_end": null,
"aa_length": 709,
"cds_start": 1107,
"cds_end": null,
"cds_length": 2130,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 7657,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.924A>C",
"hgvs_p": "p.Ala308Ala",
"transcript": "NM_199039.4",
"protein_id": "NP_950240.3",
"transcript_support_level": null,
"aa_start": 308,
"aa_end": null,
"aa_length": 648,
"cds_start": 924,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1345,
"cdna_end": null,
"cdna_length": 7535,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.684A>C",
"hgvs_p": "p.Ala228Ala",
"transcript": "NM_001171654.1",
"protein_id": "NP_001165125.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 568,
"cds_start": 684,
"cds_end": null,
"cds_length": 1707,
"cdna_start": 990,
"cdna_end": null,
"cdna_length": 7180,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_047415748.1",
"protein_id": "XP_047271704.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 804,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2415,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 3592,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_047415749.1",
"protein_id": "XP_047271705.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 804,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2415,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 10547,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_047415750.1",
"protein_id": "XP_047271706.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 804,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2415,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 3633,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1344A>C",
"hgvs_p": "p.Ala448Ala",
"transcript": "XM_047415751.1",
"protein_id": "XP_047271707.1",
"transcript_support_level": null,
"aa_start": 448,
"aa_end": null,
"aa_length": 803,
"cds_start": 1344,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 1464,
"cdna_end": null,
"cdna_length": 10544,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_011513700.3",
"protein_id": "XP_011512002.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 788,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 10373,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_011513701.3",
"protein_id": "XP_011512003.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 788,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 3175,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1344A>C",
"hgvs_p": "p.Ala448Ala",
"transcript": "XM_017008275.2",
"protein_id": "XP_016863764.1",
"transcript_support_level": null,
"aa_start": 448,
"aa_end": null,
"aa_length": 788,
"cds_start": 1344,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 1464,
"cdna_end": null,
"cdna_length": 7654,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_017008276.2",
"protein_id": "XP_016863765.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 788,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 11614,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1347A>C",
"hgvs_p": "p.Ala449Ala",
"transcript": "XM_047415752.1",
"protein_id": "XP_047271708.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 788,
"cds_start": 1347,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 1467,
"cdna_end": null,
"cdna_length": 10383,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1344A>C",
"hgvs_p": "p.Ala448Ala",
"transcript": "XM_047415753.1",
"protein_id": "XP_047271709.1",
"transcript_support_level": null,
"aa_start": 448,
"aa_end": null,
"aa_length": 787,
"cds_start": 1344,
"cds_end": null,
"cds_length": 2364,
"cdna_start": 1464,
"cdna_end": null,
"cdna_length": 10370,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1293A>C",
"hgvs_p": "p.Ala431Ala",
"transcript": "XM_047415754.1",
"protein_id": "XP_047271710.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 786,
"cds_start": 1293,
"cds_end": null,
"cds_length": 2361,
"cdna_start": 2164,
"cdna_end": null,
"cdna_length": 11244,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.1293A>C",
"hgvs_p": "p.Ala431Ala",
"transcript": "XM_047415755.1",
"protein_id": "XP_047271711.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 771,
"cds_start": 1293,
"cds_end": null,
"cds_length": 2316,
"cdna_start": 2164,
"cdna_end": null,
"cdna_length": 8354,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
"hgvs_c": "c.870A>C",
"hgvs_p": "p.Ala290Ala",
"transcript": "XM_047415756.1",
"protein_id": "XP_047271712.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 645,
"cds_start": 870,
"cds_end": null,
"cds_length": 1938,
"cdna_start": 990,
"cdna_end": null,
"cdna_length": 10070,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL5",
"gene_hgnc_id": 6356,
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}