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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 4-53383804-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=53383804&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "4",
      "pos": 53383804,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001376744.1",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "NM_030917.4",
          "protein_id": "NP_112179.2",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 594,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1785,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000337488.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_030917.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000337488.11",
          "protein_id": "ENSP00000336752.6",
          "transcript_support_level": 1,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 594,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1785,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_030917.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000337488.11"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000282278",
          "gene_hgnc_id": null,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000507166.5",
          "protein_id": "ENSP00000423325.1",
          "transcript_support_level": 2,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 849,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 2550,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000507166.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.215G>A",
          "hgvs_p": "p.Ser72Asn",
          "transcript": "ENST00000306932.10",
          "protein_id": "ENSP00000302993.6",
          "transcript_support_level": 1,
          "aa_start": 72,
          "aa_end": null,
          "aa_length": 520,
          "cds_start": 215,
          "cds_end": null,
          "cds_length": 1563,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000306932.10"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.215G>A",
          "hgvs_p": "p.Ser72Asn",
          "transcript": "ENST00000507922.5",
          "protein_id": "ENSP00000425456.1",
          "transcript_support_level": 1,
          "aa_start": 72,
          "aa_end": null,
          "aa_length": 378,
          "cds_start": 215,
          "cds_end": null,
          "cds_length": 1137,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000507922.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "n.1552G>A",
          "hgvs_p": null,
          "transcript": "ENST00000505125.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000505125.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000928373.1",
          "protein_id": "ENSP00000598432.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 607,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1824,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928373.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "NM_001376744.1",
          "protein_id": "NP_001363673.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001376744.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000871721.1",
          "protein_id": "ENSP00000541780.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000871721.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "NM_001376745.1",
          "protein_id": "NP_001363674.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 603,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1812,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001376745.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000703454.1",
          "protein_id": "ENSP00000515305.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 603,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1812,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000703454.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "NM_001376746.1",
          "protein_id": "NP_001363675.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 601,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1806,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001376746.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000703484.1",
          "protein_id": "ENSP00000515334.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 601,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1806,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000703484.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000871723.1",
          "protein_id": "ENSP00000541782.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 601,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1806,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000871723.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000928376.1",
          "protein_id": "ENSP00000598435.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 601,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1806,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928376.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000942748.1",
          "protein_id": "ENSP00000612807.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 600,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1803,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000942748.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000942744.1",
          "protein_id": "ENSP00000612803.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 597,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1794,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000942744.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "NM_001376747.1",
          "protein_id": "NP_001363676.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001376747.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000703485.1",
          "protein_id": "ENSP00000515335.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 595,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1788,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000703485.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "FIP1L1",
          "gene_hgnc_id": 19124,
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn",
          "transcript": "ENST00000703489.1",
          "protein_id": "ENSP00000515339.1",
          "transcript_support_level": null,
          "aa_start": 87,
          "aa_end": null,
          "aa_length": 594,
          "cds_start": 260,
          "cds_end": null,
          "cds_length": 1785,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
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            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001376744.1",
          "gene_symbol": "FIP1L1",
          "hgnc_id": 19124,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn"
        },
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000507166.5",
          "gene_symbol": "ENSG00000282278",
          "hgnc_id": null,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.260G>A",
          "hgvs_p": "p.Ser87Asn"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}