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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 4-54738476-G-GGT (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=54738476&ref=G&alt=GGT&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "4",
      "pos": 54738476,
      "ref": "G",
      "alt": "GGT",
      "effect": "frameshift_variant",
      "transcript": "ENST00000288135.6",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2851_2852dupGT",
          "hgvs_p": "p.Asp952fs",
          "transcript": "NM_000222.3",
          "protein_id": "NP_000213.1",
          "transcript_support_level": null,
          "aa_start": 951,
          "aa_end": null,
          "aa_length": 976,
          "cds_start": 2853,
          "cds_end": null,
          "cds_length": 2931,
          "cdna_start": 2911,
          "cdna_end": null,
          "cdna_length": 5147,
          "mane_select": "ENST00000288135.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2851_2852dupGT",
          "hgvs_p": "p.Asp952fs",
          "transcript": "ENST00000288135.6",
          "protein_id": "ENSP00000288135.6",
          "transcript_support_level": 1,
          "aa_start": 951,
          "aa_end": null,
          "aa_length": 976,
          "cds_start": 2853,
          "cds_end": null,
          "cds_length": 2931,
          "cdna_start": 2911,
          "cdna_end": null,
          "cdna_length": 5147,
          "mane_select": "NM_000222.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2839_2840dupGT",
          "hgvs_p": "p.Asp948fs",
          "transcript": "ENST00000412167.7",
          "protein_id": "ENSP00000390987.3",
          "transcript_support_level": 1,
          "aa_start": 947,
          "aa_end": null,
          "aa_length": 972,
          "cds_start": 2841,
          "cds_end": null,
          "cds_length": 2919,
          "cdna_start": 2933,
          "cdna_end": null,
          "cdna_length": 5126,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2854_2855dupGT",
          "hgvs_p": "p.Asp953fs",
          "transcript": "NM_001385284.1",
          "protein_id": "NP_001372213.1",
          "transcript_support_level": null,
          "aa_start": 952,
          "aa_end": null,
          "aa_length": 977,
          "cds_start": 2856,
          "cds_end": null,
          "cds_length": 2934,
          "cdna_start": 2914,
          "cdna_end": null,
          "cdna_length": 5150,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2854_2855dupGT",
          "hgvs_p": "p.Asp953fs",
          "transcript": "ENST00000687109.1",
          "protein_id": "ENSP00000509371.1",
          "transcript_support_level": null,
          "aa_start": 952,
          "aa_end": null,
          "aa_length": 977,
          "cds_start": 2856,
          "cds_end": null,
          "cds_length": 2934,
          "cdna_start": 2958,
          "cdna_end": null,
          "cdna_length": 5249,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2851_2852dupGT",
          "hgvs_p": "p.Asp952fs",
          "transcript": "NM_001385290.1",
          "protein_id": "NP_001372219.1",
          "transcript_support_level": null,
          "aa_start": 951,
          "aa_end": null,
          "aa_length": 976,
          "cds_start": 2853,
          "cds_end": null,
          "cds_length": 2931,
          "cdna_start": 2911,
          "cdna_end": null,
          "cdna_length": 5147,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2851_2852dupGT",
          "hgvs_p": "p.Asp952fs",
          "transcript": "ENST00000689832.1",
          "protein_id": "ENSP00000509084.1",
          "transcript_support_level": null,
          "aa_start": 951,
          "aa_end": null,
          "aa_length": 976,
          "cds_start": 2853,
          "cds_end": null,
          "cds_length": 2931,
          "cdna_start": 2901,
          "cdna_end": null,
          "cdna_length": 5098,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2848_2849dupGT",
          "hgvs_p": "p.Asp951fs",
          "transcript": "NM_001385285.1",
          "protein_id": "NP_001372214.1",
          "transcript_support_level": null,
          "aa_start": 950,
          "aa_end": null,
          "aa_length": 975,
          "cds_start": 2850,
          "cds_end": null,
          "cds_length": 2928,
          "cdna_start": 2908,
          "cdna_end": null,
          "cdna_length": 5144,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2848_2849dupGT",
          "hgvs_p": "p.Asp951fs",
          "transcript": "ENST00000692783.1",
          "protein_id": "ENSP00000508733.1",
          "transcript_support_level": null,
          "aa_start": 950,
          "aa_end": null,
          "aa_length": 975,
          "cds_start": 2850,
          "cds_end": null,
          "cds_length": 2928,
          "cdna_start": 2942,
          "cdna_end": null,
          "cdna_length": 5230,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2842_2843dupGT",
          "hgvs_p": "p.Asp949fs",
          "transcript": "NM_001385288.1",
          "protein_id": "NP_001372217.1",
          "transcript_support_level": null,
          "aa_start": 948,
          "aa_end": null,
          "aa_length": 973,
          "cds_start": 2844,
          "cds_end": null,
          "cds_length": 2922,
          "cdna_start": 2902,
          "cdna_end": null,
          "cdna_length": 5138,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
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          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2842_2843dupGT",
          "hgvs_p": "p.Asp949fs",
          "transcript": "ENST00000690543.1",
          "protein_id": "ENSP00000508831.1",
          "transcript_support_level": null,
          "aa_start": 948,
          "aa_end": null,
          "aa_length": 973,
          "cds_start": 2844,
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          "cds_length": 2922,
          "cdna_start": 2902,
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          "cdna_length": 5121,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "KIT",
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          "hgvs_c": "c.2839_2840dupGT",
          "hgvs_p": "p.Asp948fs",
          "transcript": "NM_001093772.2",
          "protein_id": "NP_001087241.1",
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          "cds_start": 2841,
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          "cdna_start": 2899,
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          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
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          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2839_2840dupGT",
          "hgvs_p": "p.Asp948fs",
          "transcript": "NM_001385292.1",
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          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2839_2840dupGT",
          "hgvs_p": "p.Asp948fs",
          "transcript": "ENST00000687295.1",
          "protein_id": "ENSP00000509450.1",
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
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          ],
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          "intron_rank": null,
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          "gene_symbol": "KIT",
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2836_2837dupGT",
          "hgvs_p": "p.Asp947fs",
          "transcript": "ENST00000686011.1",
          "protein_id": "ENSP00000509704.1",
          "transcript_support_level": null,
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          "aa_length": 971,
          "cds_start": 2838,
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          "cdna_start": 2911,
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          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2716_2717dupGT",
          "hgvs_p": "p.Asp907fs",
          "transcript": "ENST00000687246.1",
          "protein_id": "ENSP00000509114.1",
          "transcript_support_level": null,
          "aa_start": 906,
          "aa_end": null,
          "aa_length": 931,
          "cds_start": 2718,
          "cds_end": null,
          "cds_length": 2796,
          "cdna_start": 2786,
          "cdna_end": null,
          "cdna_length": 5022,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "V?",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "c.2341_2342dupGT",
          "hgvs_p": "p.Asp782fs",
          "transcript": "ENST00000689994.1",
          "protein_id": "ENSP00000509156.1",
          "transcript_support_level": null,
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          "aa_length": 806,
          "cds_start": 2343,
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          "cdna_start": 2875,
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          "cdna_length": 5091,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "n.1543_1544dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000684818.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 3777,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "n.2929_2930dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000685269.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5116,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "KIT",
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        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "KIT",
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          "hgvs_c": "n.3009_3010dupGT",
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          "transcript": "ENST00000687265.1",
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          "cdna_start": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "n.648_649dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000688060.1",
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          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 2883,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "n.3069_3070dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000690917.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 5266,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "n.1761_1762dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000691361.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 3937,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "KIT",
          "gene_hgnc_id": 6342,
          "hgvs_c": "n.2948_2949dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000692991.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4977,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "KIT",
      "gene_hgnc_id": 6342,
      "dbsnp": "rs1553893816",
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
      "splice_prediction_selected": null,
      "splice_source_selected": null,
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 0.71,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": null,
      "spliceai_max_prediction": null,
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 4,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PVS1_Moderate,PM2",
      "acmg_by_gene": [
        {
          "score": 4,
          "benign_score": 0,
          "pathogenic_score": 4,
          "criteria": [
            "PVS1_Moderate",
            "PM2"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000288135.6",
          "gene_symbol": "KIT",
          "hgnc_id": 6342,
          "effects": [
            "frameshift_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.2851_2852dupGT",
          "hgvs_p": "p.Asp952fs"
        }
      ],
      "clinvar_disease": "Dysgerminoma",
      "clinvar_classification": "other",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Dysgerminoma",
      "pathogenicity_classification_combined": "other",
      "custom_annotations": null
    }
  ],
  "message": null
}