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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-55453077-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=55453077&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 55453077,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_004898.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "NM_004898.4",
"protein_id": "NP_004889.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1600,
"cdna_end": null,
"cdna_length": 10470,
"mane_select": "ENST00000513440.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004898.4"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000513440.6",
"protein_id": "ENSP00000426983.1",
"transcript_support_level": 1,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1600,
"cdna_end": null,
"cdna_length": 10470,
"mane_select": "NM_004898.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000513440.6"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000309964.8",
"protein_id": "ENSP00000308741.4",
"transcript_support_level": 1,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1434,
"cdna_end": null,
"cdna_length": 10304,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309964.8"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000381322.5",
"protein_id": "ENSP00000370723.1",
"transcript_support_level": 1,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 2109,
"cdna_end": null,
"cdna_length": 4059,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381322.5"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "NM_001267843.2",
"protein_id": "NP_001254772.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 2109,
"cdna_end": null,
"cdna_length": 10979,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001267843.2"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000882369.1",
"protein_id": "ENSP00000552428.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 2339,
"cdna_end": null,
"cdna_length": 6637,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882369.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000882370.1",
"protein_id": "ENSP00000552429.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1678,
"cdna_end": null,
"cdna_length": 6011,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882370.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000882371.1",
"protein_id": "ENSP00000552430.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1412,
"cdna_end": null,
"cdna_length": 4291,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882371.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000882373.1",
"protein_id": "ENSP00000552432.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1932,
"cdna_end": null,
"cdna_length": 3759,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882373.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000882374.1",
"protein_id": "ENSP00000552433.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1367,
"cdna_end": null,
"cdna_length": 5665,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882374.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000926584.1",
"protein_id": "ENSP00000596643.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1552,
"cdna_end": null,
"cdna_length": 10422,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926584.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000926585.1",
"protein_id": "ENSP00000596644.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1715,
"cdna_end": null,
"cdna_length": 3665,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926585.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000926586.1",
"protein_id": "ENSP00000596645.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1828,
"cdna_end": null,
"cdna_length": 3778,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926586.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "ENST00000962775.1",
"protein_id": "ENSP00000632834.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1618,
"cdna_end": null,
"cdna_length": 3233,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962775.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_005265787.3",
"protein_id": "XP_005265844.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1607,
"cdna_end": null,
"cdna_length": 10477,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005265787.3"
},
{
"aa_ref": "L",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_011534410.3",
"protein_id": "XP_011532712.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1446,
"cdna_end": null,
"cdna_length": 10316,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011534410.3"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_011534411.3",
"protein_id": "XP_011532713.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1453,
"cdna_end": null,
"cdna_length": 10323,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011534411.3"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_017008854.2",
"protein_id": "XP_016864343.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
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"cdna_start": 1757,
"cdna_end": null,
"cdna_length": 10627,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017008854.2"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_024454284.2",
"protein_id": "XP_024310052.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1781,
"cdna_end": null,
"cdna_length": 10651,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024454284.2"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_047416431.1",
"protein_id": "XP_047272387.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
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"cdna_start": 1764,
"cdna_end": null,
"cdna_length": 10634,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047416431.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_047416432.1",
"protein_id": "XP_047272388.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
"cds_start": 1183,
"cds_end": null,
"cds_length": 2541,
"cdna_start": 1603,
"cdna_end": null,
"cdna_length": 10473,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047416432.1"
},
{
"aa_ref": "L",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLOCK",
"gene_hgnc_id": 2082,
"hgvs_c": "c.1183C>A",
"hgvs_p": "p.Leu395Ile",
"transcript": "XM_047416433.1",
"protein_id": "XP_047272389.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 846,
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}