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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 4-56650683-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=56650683&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "4",
      "pos": 56650683,
      "ref": "C",
      "alt": "T",
      "effect": "intron_variant",
      "transcript": "ENST00000420433.6",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.199-1886G>A",
          "hgvs_p": null,
          "transcript": "NM_032495.6",
          "protein_id": "NP_115884.4",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 91,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 276,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1123,
          "mane_select": "ENST00000420433.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.199-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000420433.6",
          "protein_id": "ENSP00000396275.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 91,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 276,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1123,
          "mane_select": "NM_032495.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000317745.11",
          "protein_id": "ENSP00000315198.7",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 73,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 222,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1129,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000337881.12",
          "protein_id": "ENSP00000337330.7",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 73,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 222,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 998,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000503639.7",
          "protein_id": "ENSP00000424101.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 73,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 222,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1248,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000556614.6",
          "protein_id": "ENSP00000452003.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 73,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 222,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1138,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.328G>A",
          "hgvs_p": "p.Glu110Lys",
          "transcript": "NM_001145460.2",
          "protein_id": "NP_001138932.1",
          "transcript_support_level": null,
          "aa_start": 110,
          "aa_end": null,
          "aa_length": 112,
          "cds_start": 328,
          "cds_end": null,
          "cds_length": 339,
          "cdna_start": 453,
          "cdna_end": null,
          "cdna_length": 1253,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.328G>A",
          "hgvs_p": "p.Glu110Lys",
          "transcript": "ENST00000554144.5",
          "protein_id": "ENSP00000450527.1",
          "transcript_support_level": 5,
          "aa_start": 110,
          "aa_end": null,
          "aa_length": 112,
          "cds_start": 328,
          "cds_end": null,
          "cds_length": 339,
          "cdna_start": 863,
          "cdna_end": null,
          "cdna_length": 1672,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "E",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.274G>A",
          "hgvs_p": "p.Glu92Lys",
          "transcript": "ENST00000381260.7",
          "protein_id": "ENSP00000370659.2",
          "transcript_support_level": 3,
          "aa_start": 92,
          "aa_end": null,
          "aa_length": 94,
          "cds_start": 274,
          "cds_end": null,
          "cds_length": 285,
          "cdna_start": 341,
          "cdna_end": null,
          "cdna_length": 1141,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 1,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "n.520G>A",
          "hgvs_p": null,
          "transcript": "ENST00000503864.2",
          "protein_id": null,
          "transcript_support_level": 6,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3203,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "NM_001145459.2",
          "protein_id": "NP_001138931.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 73,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 222,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1174,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "NM_001438047.1",
          "protein_id": "NP_001424976.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 1066,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "NM_139211.5",
          "protein_id": "NP_631957.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 73,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 1130,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "NM_139212.4",
          "protein_id": "NP_631958.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 73,
          "cds_start": -4,
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          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 998,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
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          "transcript": "ENST00000381255.7",
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          "mane_select": null,
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          "feature": null
        },
        {
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000508121.2",
          "protein_id": "ENSP00000422175.2",
          "transcript_support_level": 2,
          "aa_start": null,
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          "aa_length": 73,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 904,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000553379.6",
          "protein_id": "ENSP00000452340.1",
          "transcript_support_level": 2,
          "aa_start": null,
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          "aa_length": 73,
          "cds_start": -4,
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          "cds_length": 222,
          "cdna_start": null,
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          "cdna_length": 1001,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
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          "transcript": "ENST00000555760.6",
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          "biotype": null,
          "feature": null
        },
        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.145-1886G>A",
          "hgvs_p": null,
          "transcript": "ENST00000556376.6",
          "protein_id": "ENSP00000451794.1",
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          "cdna_length": 1064,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.259-1886G>A",
          "hgvs_p": null,
          "transcript": "XM_017008729.3",
          "protein_id": "XP_016864218.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 111,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 336,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1261,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "HOPX",
          "gene_hgnc_id": 24961,
          "hgvs_c": "c.199-1886G>A",
          "hgvs_p": null,
          "transcript": "XM_047416319.1",
          "protein_id": "XP_047272275.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 91,
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      "clinvar_disease": "",
      "clinvar_classification": "",
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  "message": null
}