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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-61201293-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=61201293&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 61201293,
"ref": "A",
"alt": "G",
"effect": "5_prime_UTR_variant",
"transcript": "ENST00000683033.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "NM_001387552.1",
"protein_id": "NP_001374481.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1543,
"cds_start": -4,
"cds_end": null,
"cds_length": 4632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13738,
"mane_select": "ENST00000683033.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "ENST00000683033.1",
"protein_id": "ENSP00000507980.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1543,
"cds_start": -4,
"cds_end": null,
"cds_length": 4632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13738,
"mane_select": "NM_001387552.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "ENST00000512091.6",
"protein_id": "ENSP00000423388.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1240,
"cds_start": -4,
"cds_end": null,
"cds_length": 3723,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12636,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "K",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124900173",
"gene_hgnc_id": null,
"hgvs_c": "c.1240A>G",
"hgvs_p": "p.Lys414Glu",
"transcript": "XM_047416555.1",
"protein_id": "XP_047272511.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 420,
"cds_start": 1240,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 1240,
"cdna_end": null,
"cdna_length": 22348,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "NM_001322402.3",
"protein_id": "NP_001309331.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1537,
"cds_start": -4,
"cds_end": null,
"cds_length": 4614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13720,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
"hgvs_p": null,
"transcript": "NM_001371344.2",
"protein_id": "NP_001358273.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1528,
"cds_start": -4,
"cds_end": null,
"cds_length": 4587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13627,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "NM_001387522.1",
"protein_id": "NP_001374451.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1528,
"cds_start": -4,
"cds_end": null,
"cds_length": 4587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "NM_001387523.1",
"protein_id": "NP_001374452.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1519,
"cds_start": -4,
"cds_end": null,
"cds_length": 4560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13666,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
"hgvs_p": null,
"transcript": "NM_001371345.2",
"protein_id": "NP_001358274.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1515,
"cds_start": -4,
"cds_end": null,
"cds_length": 4548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 13588,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "NM_001371343.2",
"protein_id": "NP_001358272.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1510,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
"hgvs_p": null,
"transcript": "NM_001387524.1",
"protein_id": "NP_001374453.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 23,
"intron_rank": null,
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"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
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"transcript": "NM_001387525.1",
"protein_id": "NP_001374454.1",
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 25,
"intron_rank": null,
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"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
"hgvs_p": null,
"transcript": "NM_001387526.1",
"protein_id": "NP_001374455.1",
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": 1,
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"exon_count": 25,
"intron_rank": null,
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"gene_symbol": "ADGRL3",
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"hgvs_c": "c.-646A>G",
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"transcript": "NM_001387527.1",
"protein_id": "NP_001374456.1",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
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"transcript": "NM_001387528.1",
"protein_id": "NP_001374457.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": 1,
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"intron_rank": null,
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"gene_symbol": "ADGRL3",
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"hgvs_c": "c.-646A>G",
"hgvs_p": null,
"transcript": "NM_001387529.1",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "ADGRL3",
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"hgvs_c": "c.-712A>G",
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"transcript": "NM_015236.7",
"protein_id": "NP_056051.2",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": 1,
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"intron_rank": null,
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"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
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"transcript": "NM_001387531.1",
"protein_id": "NP_001374460.1",
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},
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"protein_coding": true,
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],
"exon_rank": 1,
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"exon_count": 23,
"intron_rank": null,
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"gene_symbol": "ADGRL3",
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"hgvs_c": "c.-646A>G",
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},
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],
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"hgvs_c": "c.-712A>G",
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"transcript": "NM_001387534.1",
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},
{
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],
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"intron_rank": null,
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"transcript": "NM_001371346.2",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-646A>G",
"hgvs_p": null,
"transcript": "NM_001387535.1",
"protein_id": "NP_001374464.1",
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"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 24,
"intron_rank": null,
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"gene_symbol": "ADGRL3",
"gene_hgnc_id": 20974,
"hgvs_c": "c.-712A>G",
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"transcript": "NM_001387536.1",
"protein_id": "NP_001374465.1",
"transcript_support_level": null,
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}