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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-73420256-TA-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=73420256&ref=TA&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 73420256,
"ref": "TA",
"alt": "T",
"effect": "frameshift_variant",
"transcript": "NM_000477.7",
"consequences": [
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "NM_000477.7",
"protein_id": "NP_000468.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000295897.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000477.7"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000295897.9",
"protein_id": "ENSP00000295897.4",
"transcript_support_level": 1,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000477.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000295897.9"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1218delA",
"hgvs_p": "p.Lys406fs",
"transcript": "ENST00000415165.6",
"protein_id": "ENSP00000401820.2",
"transcript_support_level": 1,
"aa_start": 406,
"aa_end": null,
"aa_length": 417,
"cds_start": 1218,
"cds_end": null,
"cds_length": 1254,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000415165.6"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1857delA",
"hgvs_p": "p.Lys619fs",
"transcript": "ENST00000876051.1",
"protein_id": "ENSP00000546110.1",
"transcript_support_level": null,
"aa_start": 619,
"aa_end": null,
"aa_length": 630,
"cds_start": 1857,
"cds_end": null,
"cds_length": 1893,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876051.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1818delA",
"hgvs_p": "p.Lys606fs",
"transcript": "ENST00000876034.1",
"protein_id": "ENSP00000546093.1",
"transcript_support_level": null,
"aa_start": 606,
"aa_end": null,
"aa_length": 617,
"cds_start": 1818,
"cds_end": null,
"cds_length": 1854,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876034.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876006.1",
"protein_id": "ENSP00000546065.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876006.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876007.1",
"protein_id": "ENSP00000546066.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876007.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876008.1",
"protein_id": "ENSP00000546067.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876008.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876010.1",
"protein_id": "ENSP00000546069.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876010.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876014.1",
"protein_id": "ENSP00000546073.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876014.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876018.1",
"protein_id": "ENSP00000546077.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876018.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876019.1",
"protein_id": "ENSP00000546078.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876019.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876041.1",
"protein_id": "ENSP00000546100.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876041.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876047.1",
"protein_id": "ENSP00000546106.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876047.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1794delA",
"hgvs_p": "p.Lys598fs",
"transcript": "ENST00000876049.1",
"protein_id": "ENSP00000546108.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 609,
"cds_start": 1794,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876049.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1770delA",
"hgvs_p": "p.Lys590fs",
"transcript": "ENST00000876024.1",
"protein_id": "ENSP00000546083.1",
"transcript_support_level": null,
"aa_start": 590,
"aa_end": null,
"aa_length": 601,
"cds_start": 1770,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876024.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1767delA",
"hgvs_p": "p.Lys589fs",
"transcript": "ENST00000876042.1",
"protein_id": "ENSP00000546101.1",
"transcript_support_level": null,
"aa_start": 589,
"aa_end": null,
"aa_length": 600,
"cds_start": 1767,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876042.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1764delA",
"hgvs_p": "p.Lys588fs",
"transcript": "ENST00000876050.1",
"protein_id": "ENSP00000546109.1",
"transcript_support_level": null,
"aa_start": 588,
"aa_end": null,
"aa_length": 599,
"cds_start": 1764,
"cds_end": null,
"cds_length": 1800,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876050.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1755delA",
"hgvs_p": "p.Lys585fs",
"transcript": "ENST00000876031.1",
"protein_id": "ENSP00000546090.1",
"transcript_support_level": null,
"aa_start": 585,
"aa_end": null,
"aa_length": 596,
"cds_start": 1755,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876031.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1749delA",
"hgvs_p": "p.Lys583fs",
"transcript": "ENST00000876045.1",
"protein_id": "ENSP00000546104.1",
"transcript_support_level": null,
"aa_start": 583,
"aa_end": null,
"aa_length": 594,
"cds_start": 1749,
"cds_end": null,
"cds_length": 1785,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876045.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1737delA",
"hgvs_p": "p.Lys579fs",
"transcript": "ENST00000876038.1",
"protein_id": "ENSP00000546097.1",
"transcript_support_level": null,
"aa_start": 579,
"aa_end": null,
"aa_length": 590,
"cds_start": 1737,
"cds_end": null,
"cds_length": 1773,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876038.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ALB",
"gene_hgnc_id": 399,
"hgvs_c": "c.1734delA",
"hgvs_p": "p.Lys578fs",
"transcript": "ENST00000876035.1",
"protein_id": "ENSP00000546094.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 589,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876035.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
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}
],
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}