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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 4-77055221-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=77055221&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "4",
"pos": 77055221,
"ref": "C",
"alt": "T",
"effect": "stop_gained",
"transcript": "NM_001348140.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_006835.3",
"protein_id": "NP_006826.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000237654.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006835.3"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000237654.9",
"protein_id": "ENSP00000237654.4",
"transcript_support_level": 1,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006835.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000237654.9"
},
{
"aa_ref": "W",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.540G>A",
"hgvs_p": "p.Trp180*",
"transcript": "NM_001348140.2",
"protein_id": "NP_001335069.1",
"transcript_support_level": null,
"aa_start": 180,
"aa_end": null,
"aa_length": 209,
"cds_start": 540,
"cds_end": null,
"cds_length": 630,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001348140.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001348132.2",
"protein_id": "NP_001335061.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001348132.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "NM_001348133.2",
"protein_id": "NP_001335062.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001348133.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000718433.1",
"protein_id": "ENSP00000520818.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000718433.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000887844.1",
"protein_id": "ENSP00000557903.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887844.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000912007.1",
"protein_id": "ENSP00000582066.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912007.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000950255.1",
"protein_id": "ENSP00000620314.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950255.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000950256.1",
"protein_id": "ENSP00000620315.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950256.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000950260.1",
"protein_id": "ENSP00000620319.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950260.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000950261.1",
"protein_id": "ENSP00000620320.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 377,
"cds_start": 619,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950261.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.613G>A",
"hgvs_p": "p.Val205Ile",
"transcript": "ENST00000950257.1",
"protein_id": "ENSP00000620316.1",
"transcript_support_level": null,
"aa_start": 205,
"aa_end": null,
"aa_length": 375,
"cds_start": 613,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950257.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.601G>A",
"hgvs_p": "p.Val201Ile",
"transcript": "ENST00000887841.1",
"protein_id": "ENSP00000557900.1",
"transcript_support_level": null,
"aa_start": 201,
"aa_end": null,
"aa_length": 371,
"cds_start": 601,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000887841.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.577G>A",
"hgvs_p": "p.Val193Ile",
"transcript": "NM_001348134.2",
"protein_id": "NP_001335063.1",
"transcript_support_level": null,
"aa_start": 193,
"aa_end": null,
"aa_length": 363,
"cds_start": 577,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001348134.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.577G>A",
"hgvs_p": "p.Val193Ile",
"transcript": "ENST00000507788.3",
"protein_id": "ENSP00000421594.2",
"transcript_support_level": 4,
"aa_start": 193,
"aa_end": null,
"aa_length": 363,
"cds_start": 577,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000507788.3"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000912009.1",
"protein_id": "ENSP00000582068.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 356,
"cds_start": 619,
"cds_end": null,
"cds_length": 1071,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912009.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.544G>A",
"hgvs_p": "p.Val182Ile",
"transcript": "ENST00000950258.1",
"protein_id": "ENSP00000620317.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 352,
"cds_start": 544,
"cds_end": null,
"cds_length": 1059,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950258.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.619G>A",
"hgvs_p": "p.Val207Ile",
"transcript": "ENST00000950259.1",
"protein_id": "ENSP00000620318.1",
"transcript_support_level": null,
"aa_start": 207,
"aa_end": null,
"aa_length": 341,
"cds_start": 619,
"cds_end": null,
"cds_length": 1026,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950259.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.496G>A",
"hgvs_p": "p.Val166Ile",
"transcript": "NM_001348135.2",
"protein_id": "NP_001335064.1",
"transcript_support_level": null,
"aa_start": 166,
"aa_end": null,
"aa_length": 336,
"cds_start": 496,
"cds_end": null,
"cds_length": 1011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001348135.2"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.496G>A",
"hgvs_p": "p.Val166Ile",
"transcript": "ENST00000912006.1",
"protein_id": "ENSP00000582065.1",
"transcript_support_level": null,
"aa_start": 166,
"aa_end": null,
"aa_length": 336,
"cds_start": 496,
"cds_end": null,
"cds_length": 1011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912006.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNI",
"gene_hgnc_id": 1595,
"hgvs_c": "c.490G>A",
"hgvs_p": "p.Val164Ile",
"transcript": "NM_001348136.2",
"protein_id": "NP_001335065.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
"aa_length": 334,
"cds_start": 490,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001348136.2"
},
{
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