← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 4-98343151-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=4&pos=98343151&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "4",
      "pos": 98343151,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001100426.2",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "NM_001100427.2",
          "protein_id": "NP_001093897.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 607,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1824,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 3747,
          "mane_select": "ENST00000408927.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001100427.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000408927.8",
          "protein_id": "ENSP00000386153.4",
          "transcript_support_level": 2,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 607,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1824,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 3747,
          "mane_select": "NM_001100427.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000408927.8"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000339360.9",
          "protein_id": "ENSP00000340454.5",
          "transcript_support_level": 1,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 608,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1827,
          "cdna_start": 176,
          "cdna_end": null,
          "cdna_length": 2092,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000339360.9"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000453712.6",
          "protein_id": "ENSP00000407157.2",
          "transcript_support_level": 1,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 607,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1824,
          "cdna_start": 225,
          "cdna_end": null,
          "cdna_length": 2470,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000453712.6"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000380158.8",
          "protein_id": "ENSP00000369503.4",
          "transcript_support_level": 1,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 559,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1680,
          "cdna_start": 277,
          "cdna_end": null,
          "cdna_length": 2085,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000380158.8"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000408900.7",
          "protein_id": "ENSP00000386223.3",
          "transcript_support_level": 1,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 173,
          "cdna_end": null,
          "cdna_length": 1942,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000408900.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_premature_start_codon_gain_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.-116G>A",
          "hgvs_p": null,
          "transcript": "XM_047416051.1",
          "protein_id": "XP_047272007.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 527,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1584,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3526,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047416051.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.224G>A",
          "hgvs_p": "p.Ser75Asn",
          "transcript": "ENST00000945540.1",
          "protein_id": "ENSP00000615599.1",
          "transcript_support_level": null,
          "aa_start": 75,
          "aa_end": null,
          "aa_length": 640,
          "cds_start": 224,
          "cds_end": null,
          "cds_length": 1923,
          "cdna_start": 391,
          "cdna_end": null,
          "cdna_length": 2958,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945540.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "NM_001100426.2",
          "protein_id": "NP_001093896.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 608,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1827,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 3750,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001100426.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "NM_021159.5",
          "protein_id": "NP_066982.3",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 607,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1824,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 3747,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_021159.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884481.1",
          "protein_id": "ENSP00000554540.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 3325,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884481.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000884490.1",
          "protein_id": "ENSP00000554549.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 566,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1701,
          "cdna_start": 306,
          "cdna_end": null,
          "cdna_length": 2424,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884490.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000884483.1",
          "protein_id": "ENSP00000554542.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 565,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1698,
          "cdna_start": 313,
          "cdna_end": null,
          "cdna_length": 2432,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884483.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884487.1",
          "protein_id": "ENSP00000554546.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 565,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1698,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 2427,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884487.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884488.1",
          "protein_id": "ENSP00000554547.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 565,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1698,
          "cdna_start": 303,
          "cdna_end": null,
          "cdna_length": 2425,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884488.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000945541.1",
          "protein_id": "ENSP00000615600.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 565,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1698,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 2427,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945541.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000945548.1",
          "protein_id": "ENSP00000615607.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 565,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1698,
          "cdna_start": 209,
          "cdna_end": null,
          "cdna_length": 2329,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945548.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884497.1",
          "protein_id": "ENSP00000554556.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 564,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1695,
          "cdna_start": 205,
          "cdna_end": null,
          "cdna_length": 2321,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884497.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000932078.1",
          "protein_id": "ENSP00000602137.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 564,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1695,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 2426,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932078.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000945542.1",
          "protein_id": "ENSP00000615601.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 564,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1695,
          "cdna_start": 306,
          "cdna_end": null,
          "cdna_length": 2423,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945542.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000945544.1",
          "protein_id": "ENSP00000615603.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 564,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1695,
          "cdna_start": 279,
          "cdna_end": null,
          "cdna_length": 2394,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945544.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000945546.1",
          "protein_id": "ENSP00000615605.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 564,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1695,
          "cdna_start": 224,
          "cdna_end": null,
          "cdna_length": 2339,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945546.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884494.1",
          "protein_id": "ENSP00000554553.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 563,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1692,
          "cdna_start": 232,
          "cdna_end": null,
          "cdna_length": 2348,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884494.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000884496.1",
          "protein_id": "ENSP00000554555.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 560,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1683,
          "cdna_start": 229,
          "cdna_end": null,
          "cdna_length": 2330,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884496.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "NM_001100428.2",
          "protein_id": "NP_001093898.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 559,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1680,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 3603,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001100428.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884484.1",
          "protein_id": "ENSP00000554543.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 559,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1680,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 2414,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884484.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "NM_001100429.2",
          "protein_id": "NP_001093899.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 3600,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001100429.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000884480.1",
          "protein_id": "ENSP00000554539.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 306,
          "cdna_end": null,
          "cdna_length": 3602,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884480.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000932077.1",
          "protein_id": "ENSP00000602136.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 315,
          "cdna_end": null,
          "cdna_length": 2416,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932077.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884482.1",
          "protein_id": "ENSP00000554541.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 557,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1674,
          "cdna_start": 317,
          "cdna_end": null,
          "cdna_length": 2415,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884482.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.17G>A",
          "hgvs_p": "p.Ser6Asn",
          "transcript": "ENST00000945539.1",
          "protein_id": "ENSP00000615598.1",
          "transcript_support_level": null,
          "aa_start": 6,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 17,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": 118,
          "cdna_end": null,
          "cdna_length": 3409,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945539.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000945549.1",
          "protein_id": "ENSP00000615608.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": 250,
          "cdna_end": null,
          "cdna_length": 2103,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945549.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000884491.1",
          "protein_id": "ENSP00000554550.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 517,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1554,
          "cdna_start": 306,
          "cdna_end": null,
          "cdna_length": 2277,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884491.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000932079.1",
          "protein_id": "ENSP00000602138.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 517,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1554,
          "cdna_start": 306,
          "cdna_end": null,
          "cdna_length": 2281,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932079.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000945543.1",
          "protein_id": "ENSP00000615602.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 517,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1554,
          "cdna_start": 306,
          "cdna_end": null,
          "cdna_length": 2279,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945543.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "NM_001100430.2",
          "protein_id": "NP_001093900.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 516,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1551,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 3474,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001100430.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000264572.11",
          "protein_id": "ENSP00000264572.7",
          "transcript_support_level": 5,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 516,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1551,
          "cdna_start": 263,
          "cdna_end": null,
          "cdna_length": 1686,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000264572.11"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884489.1",
          "protein_id": "ENSP00000554548.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 516,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1551,
          "cdna_start": 303,
          "cdna_end": null,
          "cdna_length": 2276,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884489.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884495.1",
          "protein_id": "ENSP00000554554.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 516,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1551,
          "cdna_start": 226,
          "cdna_end": null,
          "cdna_length": 2199,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884495.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884485.1",
          "protein_id": "ENSP00000554544.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 515,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1548,
          "cdna_start": 308,
          "cdna_end": null,
          "cdna_length": 2280,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884485.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000884493.1",
          "protein_id": "ENSP00000554552.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 515,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1548,
          "cdna_start": 250,
          "cdna_end": null,
          "cdna_length": 2214,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884493.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000945538.1",
          "protein_id": "ENSP00000615597.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 515,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1548,
          "cdna_start": 277,
          "cdna_end": null,
          "cdna_length": 3440,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945538.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000945547.1",
          "protein_id": "ENSP00000615606.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 515,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1548,
          "cdna_start": 220,
          "cdna_end": null,
          "cdna_length": 2186,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000945547.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000932075.1",
          "protein_id": "ENSP00000602134.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 514,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1545,
          "cdna_start": 448,
          "cdna_end": null,
          "cdna_length": 2417,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932075.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884486.1",
          "protein_id": "ENSP00000554545.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 510,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1533,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 2264,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884486.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000884492.1",
          "protein_id": "ENSP00000554551.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 473,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1422,
          "cdna_start": 277,
          "cdna_end": null,
          "cdna_length": 2123,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000884492.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "ENST00000511212.5",
          "protein_id": "ENSP00000421599.1",
          "transcript_support_level": 4,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 157,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 475,
          "cdna_start": 208,
          "cdna_end": null,
          "cdna_length": 555,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000511212.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "ENST00000514122.5",
          "protein_id": "ENSP00000424324.1",
          "transcript_support_level": 4,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 157,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 474,
          "cdna_start": 230,
          "cdna_end": null,
          "cdna_length": 579,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000514122.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "XM_024454164.2",
          "protein_id": "XP_024309932.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 3744,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024454164.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn",
          "transcript": "XM_024454165.2",
          "protein_id": "XP_024309933.1",
          "transcript_support_level": null,
          "aa_start": 43,
          "aa_end": null,
          "aa_length": 558,
          "cds_start": 128,
          "cds_end": null,
          "cds_length": 1677,
          "cdna_start": 310,
          "cdna_end": null,
          "cdna_length": 3600,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024454165.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "N",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.125G>A",
          "hgvs_p": "p.Ser42Asn",
          "transcript": "XM_024454166.2",
          "protein_id": "XP_024309934.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 557,
          "cds_start": 125,
          "cds_end": null,
          "cds_length": 1674,
          "cdna_start": 307,
          "cdna_end": null,
          "cdna_length": 3597,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024454166.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.-116G>A",
          "hgvs_p": null,
          "transcript": "XM_047416051.1",
          "protein_id": "XP_047272007.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 527,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1584,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3526,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047416051.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.116-9325G>A",
          "hgvs_p": null,
          "transcript": "ENST00000932076.1",
          "protein_id": "ENSP00000602135.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 567,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1704,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2444,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932076.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.113-35866G>A",
          "hgvs_p": null,
          "transcript": "ENST00000932080.1",
          "protein_id": "ENSP00000602139.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 524,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1575,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2291,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932080.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.113-48801G>A",
          "hgvs_p": null,
          "transcript": "ENST00000932081.1",
          "protein_id": "ENSP00000602140.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 475,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1428,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2087,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000932081.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.113-9325G>A",
          "hgvs_p": null,
          "transcript": "ENST00000508213.5",
          "protein_id": "ENSP00000426096.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 146,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 443,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 558,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000508213.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.113-9325G>A",
          "hgvs_p": null,
          "transcript": "ENST00000509011.5",
          "protein_id": "ENSP00000425992.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 121,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 367,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 549,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000509011.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.*81G>A",
          "hgvs_p": null,
          "transcript": "ENST00000503667.5",
          "protein_id": "ENSP00000422348.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 573,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000503667.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.257G>A",
          "hgvs_p": null,
          "transcript": "ENST00000505378.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 934,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000505378.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.191G>A",
          "hgvs_p": null,
          "transcript": "ENST00000507303.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 875,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000507303.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.*81G>A",
          "hgvs_p": null,
          "transcript": "ENST00000508490.5",
          "protein_id": "ENSP00000422426.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 544,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000508490.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.125G>A",
          "hgvs_p": null,
          "transcript": "ENST00000510870.5",
          "protein_id": "ENSP00000424250.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 537,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000510870.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.231G>A",
          "hgvs_p": null,
          "transcript": "ENST00000511379.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 941,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000511379.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.237G>A",
          "hgvs_p": null,
          "transcript": "ENST00000512857.5",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 583,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000512857.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.215G>A",
          "hgvs_p": null,
          "transcript": "ENST00000515187.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 496,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000515187.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.*81G>A",
          "hgvs_p": null,
          "transcript": "ENST00000503667.5",
          "protein_id": "ENSP00000422348.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 573,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000503667.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "n.*81G>A",
          "hgvs_p": null,
          "transcript": "ENST00000508490.5",
          "protein_id": "ENSP00000422426.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 544,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000508490.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RAP1GDS1",
          "gene_hgnc_id": 9859,
          "hgvs_c": "c.-174G>A",
          "hgvs_p": null,
          "transcript": "XM_024454168.2",
          "protein_id": "XP_024309936.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 527,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1584,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3429,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024454168.2"
        }
      ],
      "gene_symbol": "RAP1GDS1",
      "gene_hgnc_id": 9859,
      "dbsnp": "rs370477193",
      "frequency_reference_population": 0.000101315236,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 163,
      "gnomad_exomes_af": 0.000107779,
      "gnomad_genomes_af": 0.0000394327,
      "gnomad_exomes_ac": 157,
      "gnomad_genomes_ac": 6,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.2762199640274048,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.142,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.7598,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.31,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 9.338,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -1,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4",
      "acmg_by_gene": [
        {
          "score": -1,
          "benign_score": 1,
          "pathogenic_score": 0,
          "criteria": [
            "BP4"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_001100426.2",
          "gene_symbol": "RAP1GDS1",
          "hgnc_id": 9859,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.128G>A",
          "hgvs_p": "p.Ser43Asn"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.