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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-10260813-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=10260813&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"effects": [
"synonymous_variant"
],
"gene_symbol": "CCT5",
"hgnc_id": 1618,
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"inheritance_mode": "AR,AD,Unknown",
"pathogenic_score": 2,
"score": 0,
"transcript": "NM_012073.5",
"verdict": "Uncertain_significance"
}
],
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_score": 0,
"allele_count_reference_population": 1,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "T",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.27,
"chr": "5",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": "Benign",
"computational_score_selected": -0.27000001072883606,
"computational_source_selected": "BayesDel_noAF",
"consequences": [
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 541,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3293,
"cdna_start": 956,
"cds_end": null,
"cds_length": 1626,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "NM_012073.5",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000280326.9",
"protein_coding": true,
"protein_id": "NP_036205.1",
"strand": true,
"transcript": "NM_012073.5",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 541,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 3293,
"cdna_start": 956,
"cds_end": null,
"cds_length": 1626,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000280326.9",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_012073.5",
"protein_coding": true,
"protein_id": "ENSP00000280326.4",
"strand": true,
"transcript": "ENST00000280326.9",
"transcript_support_level": 1
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 565,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1981,
"cdna_start": 954,
"cds_end": null,
"cds_length": 1698,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000964556.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000634615.1",
"strand": true,
"transcript": "ENST00000964556.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 549,
"aa_ref": "L",
"aa_start": 307,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1997,
"cdna_start": 971,
"cds_end": null,
"cds_length": 1650,
"cds_start": 919,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000964554.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.919C>T",
"hgvs_p": "p.Leu307Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000634613.1",
"strand": true,
"transcript": "ENST00000964554.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 547,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1994,
"cdna_start": 948,
"cds_end": null,
"cds_length": 1644,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000882453.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552512.1",
"strand": true,
"transcript": "ENST00000882453.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 538,
"aa_ref": "L",
"aa_start": 296,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3263,
"cdna_start": 928,
"cds_end": null,
"cds_length": 1617,
"cds_start": 886,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000882451.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.886C>T",
"hgvs_p": "p.Leu296Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552510.1",
"strand": true,
"transcript": "ENST00000882451.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 535,
"aa_ref": "L",
"aa_start": 293,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2019,
"cdna_start": 991,
"cds_end": null,
"cds_length": 1608,
"cds_start": 877,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000938096.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.877C>T",
"hgvs_p": "p.Leu293Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000608155.1",
"strand": true,
"transcript": "ENST00000938096.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 534,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1896,
"cdna_start": 956,
"cds_end": null,
"cds_length": 1605,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000938101.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000608160.1",
"strand": true,
"transcript": "ENST00000938101.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 520,
"aa_ref": "L",
"aa_start": 278,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3275,
"cdna_start": 915,
"cds_end": null,
"cds_length": 1563,
"cds_start": 832,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "NM_001306153.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.832C>T",
"hgvs_p": "p.Leu278Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001293082.1",
"strand": true,
"transcript": "NM_001306153.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 520,
"aa_ref": "L",
"aa_start": 278,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1933,
"cdna_start": 907,
"cds_end": null,
"cds_length": 1563,
"cds_start": 832,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000503026.5",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.832C>T",
"hgvs_p": "p.Leu278Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000423318.1",
"strand": true,
"transcript": "ENST00000503026.5",
"transcript_support_level": 2
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 518,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1725,
"cdna_start": 928,
"cds_end": null,
"cds_length": 1557,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000882457.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552516.1",
"strand": true,
"transcript": "ENST00000882457.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 512,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1735,
"cdna_start": 954,
"cds_end": null,
"cds_length": 1539,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000882456.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552515.1",
"strand": true,
"transcript": "ENST00000882456.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 508,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1873,
"cdna_start": 948,
"cds_end": null,
"cds_length": 1527,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000964555.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000634614.1",
"strand": true,
"transcript": "ENST00000964555.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 503,
"aa_ref": "L",
"aa_start": 261,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3484,
"cdna_start": 1147,
"cds_end": null,
"cds_length": 1512,
"cds_start": 781,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "NM_001306156.2",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.781C>T",
"hgvs_p": "p.Leu261Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001293085.1",
"strand": true,
"transcript": "NM_001306156.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 503,
"aa_ref": "L",
"aa_start": 261,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1997,
"cdna_start": 1147,
"cds_end": null,
"cds_length": 1512,
"cds_start": 781,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000515676.5",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.781C>T",
"hgvs_p": "p.Leu261Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000427297.1",
"strand": true,
"transcript": "ENST00000515676.5",
"transcript_support_level": 2
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 495,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1773,
"cdna_start": 949,
"cds_end": null,
"cds_length": 1488,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000938103.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000608162.1",
"strand": true,
"transcript": "ENST00000938103.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 486,
"aa_ref": "L",
"aa_start": 244,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3128,
"cdna_start": 791,
"cds_end": null,
"cds_length": 1461,
"cds_start": 730,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "NM_001306154.2",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.730C>T",
"hgvs_p": "p.Leu244Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001293083.1",
"strand": true,
"transcript": "NM_001306154.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 486,
"aa_ref": "L",
"aa_start": 244,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1728,
"cdna_start": 855,
"cds_end": null,
"cds_length": 1461,
"cds_start": 730,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000515390.5",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.730C>T",
"hgvs_p": "p.Leu244Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000426923.1",
"strand": true,
"transcript": "ENST00000515390.5",
"transcript_support_level": 2
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 479,
"aa_ref": "L",
"aa_start": 299,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1835,
"cdna_start": 993,
"cds_end": null,
"cds_length": 1440,
"cds_start": 895,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000938097.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.895C>T",
"hgvs_p": "p.Leu299Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000608156.1",
"strand": true,
"transcript": "ENST00000938097.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 448,
"aa_ref": "L",
"aa_start": 206,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3319,
"cdna_start": 982,
"cds_end": null,
"cds_length": 1347,
"cds_start": 616,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "NM_001306155.2",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.616C>T",
"hgvs_p": "p.Leu206Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001293084.1",
"strand": true,
"transcript": "NM_001306155.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 448,
"aa_ref": "L",
"aa_start": 206,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1939,
"cdna_start": 980,
"cds_end": null,
"cds_length": 1347,
"cds_start": 616,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000506600.1",
"gene_hgnc_id": 1618,
"gene_symbol": "CCT5",
"hgvs_c": "c.616C>T",
"hgvs_p": "p.Leu206Leu",
"intron_rank": null,
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