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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 5-1324786-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=1324786&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "5",
      "pos": 1324786,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_030782.5",
      "consequences": [
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1174A>G",
          "hgvs_p": "p.Lys392Glu",
          "transcript": "NM_030782.5",
          "protein_id": "NP_110409.2",
          "transcript_support_level": null,
          "aa_start": 392,
          "aa_end": null,
          "aa_length": 538,
          "cds_start": 1174,
          "cds_end": null,
          "cds_length": 1617,
          "cdna_start": 1432,
          "cdna_end": null,
          "cdna_length": 2492,
          "mane_select": "ENST00000320895.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_030782.5"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1174A>G",
          "hgvs_p": "p.Lys392Glu",
          "transcript": "ENST00000320895.10",
          "protein_id": "ENSP00000313854.5",
          "transcript_support_level": 1,
          "aa_start": 392,
          "aa_end": null,
          "aa_length": 538,
          "cds_start": 1174,
          "cds_end": null,
          "cds_length": 1617,
          "cdna_start": 1432,
          "cdna_end": null,
          "cdna_length": 2492,
          "mane_select": "NM_030782.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000320895.10"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.667A>G",
          "hgvs_p": "p.Lys223Glu",
          "transcript": "ENST00000507807.3",
          "protein_id": "ENSP00000423321.1",
          "transcript_support_level": 1,
          "aa_start": 223,
          "aa_end": null,
          "aa_length": 369,
          "cds_start": 667,
          "cds_end": null,
          "cds_length": 1110,
          "cdna_start": 681,
          "cdna_end": null,
          "cdna_length": 1740,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000507807.3"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1378A>G",
          "hgvs_p": "p.Lys460Glu",
          "transcript": "ENST00000966757.1",
          "protein_id": "ENSP00000636816.1",
          "transcript_support_level": null,
          "aa_start": 460,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1378,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 1607,
          "cdna_end": null,
          "cdna_length": 2558,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966757.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1171A>G",
          "hgvs_p": "p.Lys391Glu",
          "transcript": "ENST00000879373.1",
          "protein_id": "ENSP00000549432.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 537,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 1614,
          "cdna_start": 1406,
          "cdna_end": null,
          "cdna_length": 2474,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879373.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1174A>G",
          "hgvs_p": "p.Lys392Glu",
          "transcript": "ENST00000924966.1",
          "protein_id": "ENSP00000595025.1",
          "transcript_support_level": null,
          "aa_start": 392,
          "aa_end": null,
          "aa_length": 537,
          "cds_start": 1174,
          "cds_end": null,
          "cds_length": 1614,
          "cdna_start": 1402,
          "cdna_end": null,
          "cdna_length": 2453,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924966.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1174A>G",
          "hgvs_p": "p.Lys392Glu",
          "transcript": "ENST00000966760.1",
          "protein_id": "ENSP00000636819.1",
          "transcript_support_level": null,
          "aa_start": 392,
          "aa_end": null,
          "aa_length": 536,
          "cds_start": 1174,
          "cds_end": null,
          "cds_length": 1611,
          "cdna_start": 1341,
          "cdna_end": null,
          "cdna_length": 2279,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966760.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1162A>G",
          "hgvs_p": "p.Lys388Glu",
          "transcript": "ENST00000924967.1",
          "protein_id": "ENSP00000595026.1",
          "transcript_support_level": null,
          "aa_start": 388,
          "aa_end": null,
          "aa_length": 534,
          "cds_start": 1162,
          "cds_end": null,
          "cds_length": 1605,
          "cdna_start": 1391,
          "cdna_end": null,
          "cdna_length": 2343,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924967.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1174A>G",
          "hgvs_p": "p.Lys392Glu",
          "transcript": "ENST00000966756.1",
          "protein_id": "ENSP00000636815.1",
          "transcript_support_level": null,
          "aa_start": 392,
          "aa_end": null,
          "aa_length": 523,
          "cds_start": 1174,
          "cds_end": null,
          "cds_length": 1572,
          "cdna_start": 1395,
          "cdna_end": null,
          "cdna_length": 2407,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966756.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1171A>G",
          "hgvs_p": "p.Lys391Glu",
          "transcript": "ENST00000924969.1",
          "protein_id": "ENSP00000595028.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": 1399,
          "cdna_end": null,
          "cdna_length": 2299,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924969.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1108A>G",
          "hgvs_p": "p.Lys370Glu",
          "transcript": "ENST00000966759.1",
          "protein_id": "ENSP00000636818.1",
          "transcript_support_level": null,
          "aa_start": 370,
          "aa_end": null,
          "aa_length": 516,
          "cds_start": 1108,
          "cds_end": null,
          "cds_length": 1551,
          "cdna_start": 1277,
          "cdna_end": null,
          "cdna_length": 2220,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966759.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.985A>G",
          "hgvs_p": "p.Lys329Glu",
          "transcript": "ENST00000966758.1",
          "protein_id": "ENSP00000636817.1",
          "transcript_support_level": null,
          "aa_start": 329,
          "aa_end": null,
          "aa_length": 475,
          "cds_start": 985,
          "cds_end": null,
          "cds_length": 1428,
          "cdna_start": 1156,
          "cdna_end": null,
          "cdna_length": 2100,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000966758.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.982A>G",
          "hgvs_p": "p.Lys328Glu",
          "transcript": "ENST00000924970.1",
          "protein_id": "ENSP00000595029.1",
          "transcript_support_level": null,
          "aa_start": 328,
          "aa_end": null,
          "aa_length": 474,
          "cds_start": 982,
          "cds_end": null,
          "cds_length": 1425,
          "cdna_start": 1207,
          "cdna_end": null,
          "cdna_length": 2150,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924970.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.667A>G",
          "hgvs_p": "p.Lys223Glu",
          "transcript": "ENST00000630539.1",
          "protein_id": "ENSP00000485923.1",
          "transcript_support_level": 5,
          "aa_start": 223,
          "aa_end": null,
          "aa_length": 369,
          "cds_start": 667,
          "cds_end": null,
          "cds_length": 1110,
          "cdna_start": 1112,
          "cdna_end": null,
          "cdna_length": 2032,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000630539.1"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1171A>G",
          "hgvs_p": "p.Lys391Glu",
          "transcript": "XM_011514144.3",
          "protein_id": "XP_011512446.1",
          "transcript_support_level": null,
          "aa_start": 391,
          "aa_end": null,
          "aa_length": 537,
          "cds_start": 1171,
          "cds_end": null,
          "cds_length": 1614,
          "cdna_start": 1429,
          "cdna_end": null,
          "cdna_length": 2489,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011514144.3"
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.640A>G",
          "hgvs_p": "p.Lys214Glu",
          "transcript": "XM_024446222.2",
          "protein_id": "XP_024301990.1",
          "transcript_support_level": null,
          "aa_start": 214,
          "aa_end": null,
          "aa_length": 360,
          "cds_start": 640,
          "cds_end": null,
          "cds_length": 1083,
          "cdna_start": 755,
          "cdna_end": null,
          "cdna_length": 1815,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024446222.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 10,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "c.1147-917A>G",
          "hgvs_p": null,
          "transcript": "ENST00000924968.1",
          "protein_id": "ENSP00000595027.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 521,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1566,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2297,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924968.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "n.2596A>G",
          "hgvs_p": null,
          "transcript": "ENST00000503042.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3540,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000503042.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "n.443A>G",
          "hgvs_p": null,
          "transcript": "ENST00000503151.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 627,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000503151.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPTM1L",
          "gene_hgnc_id": 24308,
          "hgvs_c": "n.105A>G",
          "hgvs_p": null,
          "transcript": "ENST00000503534.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
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        {
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          "biotype": "pseudogene",
          "feature": "ENST00000513250.1"
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      ],
      "gene_symbol": "CLPTM1L",
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      "gnomad_genomes_ac": null,
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      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.191277414560318,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.05000000074505806,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.05,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1611,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.51,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 4.208,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0.05,
      "spliceai_max_prediction": "Benign",
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      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
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            "PM2",
            "BP4_Moderate"
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          "verdict": "Uncertain_significance",
          "transcript": "NM_030782.5",
          "gene_symbol": "CLPTM1L",
          "hgnc_id": 24308,
          "effects": [
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          "inheritance_mode": "",
          "hgvs_c": "c.1174A>G",
          "hgvs_p": "p.Lys392Glu"
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      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.