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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-141634927-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=141634927&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 141634927,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001355039.2",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "NM_003883.4",
"protein_id": "NP_003874.2",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 428,
"cds_start": 165,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000305264.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003883.4"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000305264.8",
"protein_id": "ENSP00000302967.3",
"transcript_support_level": 1,
"aa_start": 55,
"aa_end": null,
"aa_length": 428,
"cds_start": 165,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003883.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000305264.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "n.238A>G",
"hgvs_p": null,
"transcript": "ENST00000469550.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000469550.6"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000937593.1",
"protein_id": "ENSP00000607652.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 436,
"cds_start": 165,
"cds_end": null,
"cds_length": 1311,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937593.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "NM_001355039.2",
"protein_id": "NP_001341968.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 434,
"cds_start": 165,
"cds_end": null,
"cds_length": 1305,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001355039.2"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000856306.1",
"protein_id": "ENSP00000526365.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 433,
"cds_start": 165,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856306.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000940960.1",
"protein_id": "ENSP00000611019.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 432,
"cds_start": 165,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940960.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.162A>G",
"hgvs_p": "p.Gln54Gln",
"transcript": "ENST00000940958.1",
"protein_id": "ENSP00000611017.1",
"transcript_support_level": null,
"aa_start": 54,
"aa_end": null,
"aa_length": 427,
"cds_start": 162,
"cds_end": null,
"cds_length": 1284,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940958.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.156A>G",
"hgvs_p": "p.Gln52Gln",
"transcript": "ENST00000856307.1",
"protein_id": "ENSP00000526366.1",
"transcript_support_level": null,
"aa_start": 52,
"aa_end": null,
"aa_length": 425,
"cds_start": 156,
"cds_end": null,
"cds_length": 1278,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856307.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.147A>G",
"hgvs_p": "p.Gln49Gln",
"transcript": "ENST00000937591.1",
"protein_id": "ENSP00000607650.1",
"transcript_support_level": null,
"aa_start": 49,
"aa_end": null,
"aa_length": 422,
"cds_start": 147,
"cds_end": null,
"cds_length": 1269,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937591.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000937592.1",
"protein_id": "ENSP00000607651.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 415,
"cds_start": 165,
"cds_end": null,
"cds_length": 1248,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937592.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000940957.1",
"protein_id": "ENSP00000611016.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 409,
"cds_start": 165,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940957.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000856308.1",
"protein_id": "ENSP00000526367.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 398,
"cds_start": 165,
"cds_end": null,
"cds_length": 1197,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856308.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000940959.1",
"protein_id": "ENSP00000611018.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 395,
"cds_start": 165,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940959.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000937595.1",
"protein_id": "ENSP00000607654.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 363,
"cds_start": 165,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937595.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.165A>G",
"hgvs_p": "p.Gln55Gln",
"transcript": "ENST00000856309.1",
"protein_id": "ENSP00000526368.1",
"transcript_support_level": null,
"aa_start": 55,
"aa_end": null,
"aa_length": 245,
"cds_start": 165,
"cds_end": null,
"cds_length": 738,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856309.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.139-28A>G",
"hgvs_p": null,
"transcript": "ENST00000937590.1",
"protein_id": "ENSP00000607649.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 410,
"cds_start": null,
"cds_end": null,
"cds_length": 1233,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937590.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.138+1621A>G",
"hgvs_p": null,
"transcript": "ENST00000937594.1",
"protein_id": "ENSP00000607653.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": null,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937594.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.-123+1621A>G",
"hgvs_p": null,
"transcript": "NM_001355040.2",
"protein_id": "NP_001341969.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 275,
"cds_start": null,
"cds_end": null,
"cds_length": 828,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001355040.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.-281+1621A>G",
"hgvs_p": null,
"transcript": "NM_001355041.2",
"protein_id": "NP_001341970.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 241,
"cds_start": null,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001355041.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.138+1621A>G",
"hgvs_p": null,
"transcript": "ENST00000523088.5",
"protein_id": "ENSP00000429099.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 217,
"cds_start": null,
"cds_end": null,
"cds_length": 656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000523088.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "HDAC3",
"gene_hgnc_id": 4854,
"hgvs_c": "c.138+1621A>G",
"hgvs_p": null,
"transcript": "ENST00000937596.1",
"protein_id": "ENSP00000607655.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 121,
"cds_start": null,
"cds_end": null,
"cds_length": 366,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937596.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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}
],
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}