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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-146878727-AGCTGCTGCTGCTGCTGCTGCTGCT-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=146878727&ref=AGCTGCTGCTGCTGCTGCTGCTGCT&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 146878727,
"ref": "AGCTGCTGCTGCTGCTGCTGCTGCT",
"alt": "A",
"effect": "5_prime_UTR_variant",
"transcript": "ENST00000394411.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "n.144_167delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000530902.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2093,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-285_-262delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_181675.4",
"protein_id": "NP_858061.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 443,
"cds_start": -4,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10828,
"mane_select": "ENST00000394411.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-285_-262delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000394411.9",
"protein_id": "ENSP00000377933.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 443,
"cds_start": -4,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10828,
"mane_select": "NM_181675.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-798_-775delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000453001.5",
"protein_id": "ENSP00000398779.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 432,
"cds_start": -4,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2569,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.75-556_75-533delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000394414.5",
"protein_id": "ENSP00000377936.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 509,
"cds_start": -4,
"cds_end": null,
"cds_length": 1530,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2262,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "n.-175_-152delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000532154.5",
"protein_id": "ENSP00000434497.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-680_-657delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_001428277.1",
"protein_id": "NP_001415206.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 443,
"cds_start": -4,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11223,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-175_-152delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_001428279.1",
"protein_id": "NP_001415208.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 443,
"cds_start": -4,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10718,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-798_-775delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_001271948.2",
"protein_id": "NP_001258877.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 432,
"cds_start": -4,
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"cds_length": 1299,
"cdna_start": null,
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"cdna_length": 11308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "n.-175_-152delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000532154.5",
"protein_id": "ENSP00000434497.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.75-556_75-533delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_181674.3",
"protein_id": "NP_858060.2",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 509,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.51-556_51-533delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_001271900.2",
"protein_id": "NP_001258829.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 501,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 2,
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"gene_symbol": "PPP2R2B",
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"hgvs_c": "c.51-556_51-533delAGCAGCAGCAGCAGCAGCAGCAGC",
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"transcript": "ENST00000394413.7",
"protein_id": "ENSP00000377935.4",
"transcript_support_level": 2,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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],
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 2,
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"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.89-177609_89-177586delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000504198.5",
"protein_id": "ENSP00000421396.1",
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"aa_start": null,
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},
{
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],
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"hgvs_c": "c.79+176914_79+176937delAGCAGCAGCAGCAGCAGCAGCAGC",
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"transcript": "NM_181676.3",
"protein_id": "NP_858062.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 1,
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"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.79+176914_79+176937delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000336640.10",
"protein_id": "ENSP00000336591.6",
"transcript_support_level": 5,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.-48-22168_-48-22145delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "NM_181678.2",
"protein_id": "NP_858064.1",
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "PPP2R2B",
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"hgvs_c": "c.-48-22168_-48-22145delAGCAGCAGCAGCAGCAGCAGCAGC",
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"transcript": "ENST00000508545.6",
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},
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],
"exon_rank": null,
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"gene_symbol": "PPP2R2B",
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"hgvs_p": null,
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "c.10+156418_10+156441delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000508267.5",
"protein_id": "ENSP00000421224.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPP2R2B",
"gene_hgnc_id": 9305,
"hgvs_c": "n.362+40933_362+40956delAGCAGCAGCAGCAGCAGCAGCAGC",
"hgvs_p": null,
"transcript": "ENST00000502876.1",
"protein_id": null,
"transcript_support_level": 4,
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},
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}