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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 5-150396821-G-GAGA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=150396821&ref=G&alt=GAGA&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "5",
      "pos": 150396821,
      "ref": "G",
      "alt": "GAGA",
      "effect": "disruptive_inframe_insertion",
      "transcript": "ENST00000643257.2",
      "consequences": [
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4332_4334dupGAA",
          "hgvs_p": "p.Lys1445dup",
          "transcript": "NM_001371623.1",
          "protein_id": "NP_001358552.1",
          "transcript_support_level": null,
          "aa_start": 1445,
          "aa_end": null,
          "aa_length": 1489,
          "cds_start": 4335,
          "cds_end": null,
          "cds_length": 4470,
          "cdna_start": 4385,
          "cdna_end": null,
          "cdna_length": 5026,
          "mane_select": "ENST00000643257.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4332_4334dupGAA",
          "hgvs_p": "p.Lys1445dup",
          "transcript": "ENST00000643257.2",
          "protein_id": "ENSP00000493815.1",
          "transcript_support_level": null,
          "aa_start": 1445,
          "aa_end": null,
          "aa_length": 1489,
          "cds_start": 4335,
          "cds_end": null,
          "cds_length": 4470,
          "cdna_start": 4385,
          "cdna_end": null,
          "cdna_length": 5026,
          "mane_select": "NM_001371623.1",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4329_4331dupGAA",
          "hgvs_p": "p.Lys1444dup",
          "transcript": "ENST00000504761.6",
          "protein_id": "ENSP00000421655.2",
          "transcript_support_level": 1,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1488,
          "cds_start": 4332,
          "cds_end": null,
          "cds_length": 4467,
          "cdna_start": 4332,
          "cdna_end": null,
          "cdna_length": 4467,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4098_4100dupGAA",
          "hgvs_p": "p.Lys1367dup",
          "transcript": "ENST00000323668.11",
          "protein_id": "ENSP00000325223.6",
          "transcript_support_level": 1,
          "aa_start": 1367,
          "aa_end": null,
          "aa_length": 1411,
          "cds_start": 4101,
          "cds_end": null,
          "cds_length": 4236,
          "cdna_start": 4176,
          "cdna_end": null,
          "cdna_length": 4832,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4329_4331dupGAA",
          "hgvs_p": "p.Lys1444dup",
          "transcript": "NM_001135243.2",
          "protein_id": "NP_001128715.1",
          "transcript_support_level": null,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1488,
          "cds_start": 4332,
          "cds_end": null,
          "cds_length": 4467,
          "cdna_start": 4382,
          "cdna_end": null,
          "cdna_length": 5023,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4329_4331dupGAA",
          "hgvs_p": "p.Lys1444dup",
          "transcript": "ENST00000377797.7",
          "protein_id": "ENSP00000367028.4",
          "transcript_support_level": 5,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1488,
          "cds_start": 4332,
          "cds_end": null,
          "cds_length": 4467,
          "cdna_start": 4440,
          "cdna_end": null,
          "cdna_length": 5095,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4329_4331dupGAA",
          "hgvs_p": "p.Lys1444dup",
          "transcript": "ENST00000513346.5",
          "protein_id": "ENSP00000427484.1",
          "transcript_support_level": 5,
          "aa_start": 1444,
          "aa_end": null,
          "aa_length": 1488,
          "cds_start": 4332,
          "cds_end": null,
          "cds_length": 4467,
          "cdna_start": 4332,
          "cdna_end": null,
          "cdna_length": 4646,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4218_4220dupGAA",
          "hgvs_p": "p.Lys1407dup",
          "transcript": "NM_001135244.2",
          "protein_id": "NP_001128716.1",
          "transcript_support_level": null,
          "aa_start": 1407,
          "aa_end": null,
          "aa_length": 1451,
          "cds_start": 4221,
          "cds_end": null,
          "cds_length": 4356,
          "cdna_start": 4271,
          "cdna_end": null,
          "cdna_length": 4912,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "KK",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4218_4220dupGAA",
          "hgvs_p": "p.Lys1407dup",
          "transcript": "ENST00000439160.6",
          "protein_id": "ENSP00000406888.2",
          "transcript_support_level": 5,
          "aa_start": 1407,
          "aa_end": null,
          "aa_length": 1451,
          "cds_start": 4221,
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          "cdna_start": 4254,
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          "cdna_length": 4644,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "disruptive_inframe_insertion"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
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          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4215_4217dupGAA",
          "hgvs_p": "p.Lys1406dup",
          "transcript": "NM_001195141.2",
          "protein_id": "NP_001182070.1",
          "transcript_support_level": null,
          "aa_start": 1406,
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          "mane_select": null,
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
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          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4215_4217dupGAA",
          "hgvs_p": "p.Lys1406dup",
          "transcript": "ENST00000427724.7",
          "protein_id": "ENSP00000390717.3",
          "transcript_support_level": 5,
          "aa_start": 1406,
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          "cds_start": 4218,
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          "cdna_start": 4246,
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        {
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          "strand": true,
          "consequences": [
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          "intron_rank": null,
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          "gene_symbol": "TCOF1",
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          "hgvs_c": "c.4101_4103dupGAA",
          "hgvs_p": "p.Lys1368dup",
          "transcript": "NM_001135245.2",
          "protein_id": "NP_001128717.1",
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          "cds_start": 4104,
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        },
        {
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          "strand": true,
          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "TCOF1",
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          "hgvs_c": "c.4101_4103dupGAA",
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        },
        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4098_4100dupGAA",
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          "transcript": "NM_000356.4",
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        {
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          "gene_symbol": "TCOF1",
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          "hgvs_c": "c.4098_4100dupGAA",
          "hgvs_p": "p.Lys1367dup",
          "transcript": "NM_001437406.1",
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        },
        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.3987_3989dupGAA",
          "hgvs_p": "p.Lys1330dup",
          "transcript": "ENST00000650162.1",
          "protein_id": "ENSP00000497075.1",
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        {
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.429_431dupGAA",
          "hgvs_p": "p.Lys144dup",
          "transcript": "ENST00000515516.1",
          "protein_id": "ENSP00000426471.1",
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        {
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          "transcript": "XM_005268503.5",
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        },
        {
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          "strand": true,
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          ],
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          "exon_count": 28,
          "intron_rank": null,
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          "gene_symbol": "TCOF1",
          "gene_hgnc_id": 11654,
          "hgvs_c": "c.4440_4442dupGAA",
          "hgvs_p": "p.Lys1481dup",
          "transcript": "XM_005268504.5",
          "protein_id": "XP_005268561.1",
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            "PM4_Supporting"
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      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
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      "custom_annotations": null
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}