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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 5-168244657-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=168244657&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 4,
          "criteria": [
            "PP3_Moderate",
            "BS2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "TENM2",
          "hgnc_id": 29943,
          "hgvs_c": "c.5758C>T",
          "hgvs_p": "p.Arg1920Cys",
          "inheritance_mode": "AD",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "NM_001395460.1",
          "verdict": "Likely_benign"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "TENM2-AS1",
          "hgnc_id": 56066,
          "hgvs_c": "n.198-12285G>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 4,
          "score": 4,
          "transcript": "ENST00000519795.2",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PP3_Moderate,BS2",
      "acmg_score": -2,
      "allele_count_reference_population": 16,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.499,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.4,
      "chr": "5",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.894587516784668,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2774,
          "aa_ref": "R",
          "aa_start": 1920,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10356,
          "cdna_start": 6442,
          "cds_end": null,
          "cds_length": 8325,
          "cds_start": 5758,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "NM_001395460.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5758C>T",
          "hgvs_p": "p.Arg1920Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000518659.6",
          "protein_coding": true,
          "protein_id": "NP_001382389.1",
          "strand": true,
          "transcript": "NM_001395460.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2774,
          "aa_ref": "R",
          "aa_start": 1920,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 10356,
          "cdna_start": 6442,
          "cds_end": null,
          "cds_length": 8325,
          "cds_start": 5758,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000518659.6",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5758C>T",
          "hgvs_p": "p.Arg1920Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001395460.1",
          "protein_coding": true,
          "protein_id": "ENSP00000429430.1",
          "strand": true,
          "transcript": "ENST00000518659.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2535,
          "aa_ref": "R",
          "aa_start": 1681,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8034,
          "cdna_start": 5092,
          "cds_end": null,
          "cds_length": 7608,
          "cds_start": 5041,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000520394.5",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5041C>T",
          "hgvs_p": "p.Arg1681Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000427874.1",
          "strand": true,
          "transcript": "ENST00000520394.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2765,
          "aa_ref": "R",
          "aa_start": 1911,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9834,
          "cdna_start": 5920,
          "cds_end": null,
          "cds_length": 8298,
          "cds_start": 5731,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "NM_001122679.2",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5731C>T",
          "hgvs_p": "p.Arg1911Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001116151.1",
          "strand": true,
          "transcript": "NM_001122679.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2653,
          "aa_ref": "R",
          "aa_start": 1799,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9427,
          "cdna_start": 5513,
          "cds_end": null,
          "cds_length": 7962,
          "cds_start": 5395,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 28,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000519204.5",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5395C>T",
          "hgvs_p": "p.Arg1799Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000428964.1",
          "strand": true,
          "transcript": "ENST00000519204.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2615,
          "aa_ref": "R",
          "aa_start": 1761,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9517,
          "cdna_start": 5603,
          "cds_end": null,
          "cds_length": 7848,
          "cds_start": 5281,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "NM_001368145.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5281C>T",
          "hgvs_p": "p.Arg1761Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001355074.1",
          "strand": true,
          "transcript": "NM_001368145.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2613,
          "aa_ref": "R",
          "aa_start": 1759,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9511,
          "cdna_start": 5597,
          "cds_end": null,
          "cds_length": 7842,
          "cds_start": 5275,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 28,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "NM_001368146.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5275C>T",
          "hgvs_p": "p.Arg1759Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001355075.1",
          "strand": true,
          "transcript": "NM_001368146.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2613,
          "aa_ref": "R",
          "aa_start": 1759,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9500,
          "cdna_start": 5597,
          "cds_end": null,
          "cds_length": 7842,
          "cds_start": 5275,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 28,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000695886.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5275C>T",
          "hgvs_p": "p.Arg1759Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000512239.1",
          "strand": true,
          "transcript": "ENST00000695886.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2577,
          "aa_ref": "R",
          "aa_start": 1723,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10354,
          "cdna_start": 6819,
          "cds_end": null,
          "cds_length": 7734,
          "cds_start": 5167,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 28,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000695961.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5167C>T",
          "hgvs_p": "p.Arg1723Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000512289.1",
          "strand": true,
          "transcript": "ENST00000695961.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2535,
          "aa_ref": "R",
          "aa_start": 1681,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9080,
          "cdna_start": 5166,
          "cds_end": null,
          "cds_length": 7608,
          "cds_start": 5041,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "NM_001080428.3",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5041C>T",
          "hgvs_p": "p.Arg1681Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001073897.2",
          "strand": true,
          "transcript": "NM_001080428.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2369,
          "aa_ref": "R",
          "aa_start": 1515,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9271,
          "cdna_start": 5359,
          "cds_end": null,
          "cds_length": 7110,
          "cds_start": 4543,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "ENST00000695962.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.4543C>T",
          "hgvs_p": "p.Arg1515Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000512290.1",
          "strand": true,
          "transcript": "ENST00000695962.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2767,
          "aa_ref": "R",
          "aa_start": 1913,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10335,
          "cdna_start": 6421,
          "cds_end": null,
          "cds_length": 8304,
          "cds_start": 5737,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "XM_017009661.2",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5737C>T",
          "hgvs_p": "p.Arg1913Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016865150.1",
          "strand": true,
          "transcript": "XM_017009661.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2765,
          "aa_ref": "R",
          "aa_start": 1911,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10329,
          "cdna_start": 6415,
          "cds_end": null,
          "cds_length": 8298,
          "cds_start": 5731,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "XM_005265950.3",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5731C>T",
          "hgvs_p": "p.Arg1911Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_005266007.1",
          "strand": true,
          "transcript": "XM_005265950.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2758,
          "aa_ref": "R",
          "aa_start": 1904,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10388,
          "cdna_start": 6474,
          "cds_end": null,
          "cds_length": 8277,
          "cds_start": 5710,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "XM_047417418.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5710C>T",
          "hgvs_p": "p.Arg1904Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047273374.1",
          "strand": true,
          "transcript": "XM_047417418.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2704,
          "aa_ref": "R",
          "aa_start": 1850,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10146,
          "cdna_start": 6232,
          "cds_end": null,
          "cds_length": 8115,
          "cds_start": 5548,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "XM_017009662.2",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5548C>T",
          "hgvs_p": "p.Arg1850Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016865151.1",
          "strand": true,
          "transcript": "XM_017009662.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2703,
          "aa_ref": "R",
          "aa_start": 1849,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10143,
          "cdna_start": 6229,
          "cds_end": null,
          "cds_length": 8112,
          "cds_start": 5545,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "XM_011534604.3",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5545C>T",
          "hgvs_p": "p.Arg1849Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011532906.1",
          "strand": true,
          "transcript": "XM_011534604.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2699,
          "aa_ref": "R",
          "aa_start": 1845,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9453,
          "cdna_start": 5539,
          "cds_end": null,
          "cds_length": 8100,
          "cds_start": 5533,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 28,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "XM_017009663.3",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5533C>T",
          "hgvs_p": "p.Arg1845Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016865152.1",
          "strand": true,
          "transcript": "XM_017009663.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2697,
          "aa_ref": "R",
          "aa_start": 1843,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 10125,
          "cdna_start": 6211,
          "cds_end": null,
          "cds_length": 8094,
          "cds_start": 5527,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 29,
          "exon_rank": 26,
          "exon_rank_end": null,
          "feature": "XM_047417419.1",
          "gene_hgnc_id": 29943,
          "gene_symbol": "TENM2",
          "hgvs_c": "c.5527C>T",
          "hgvs_p": "p.Arg1843Cys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047273375.1",
          "strand": true,
          "transcript": "XM_047417419.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 2696,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.