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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-171870806-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=171870806&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 171870806,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001378974.1",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1393G>A",
"hgvs_p": "p.Glu465Lys",
"transcript": "NM_001378974.1",
"protein_id": "NP_001365903.1",
"transcript_support_level": null,
"aa_start": 465,
"aa_end": null,
"aa_length": 563,
"cds_start": 1393,
"cds_end": null,
"cds_length": 1692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000517395.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378974.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1393G>A",
"hgvs_p": "p.Glu465Lys",
"transcript": "ENST00000517395.6",
"protein_id": "ENSP00000428753.2",
"transcript_support_level": 3,
"aa_start": 465,
"aa_end": null,
"aa_length": 563,
"cds_start": 1393,
"cds_end": null,
"cds_length": 1692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001378974.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000517395.6"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1330G>A",
"hgvs_p": "p.Glu444Lys",
"transcript": "ENST00000265094.9",
"protein_id": "ENSP00000265094.5",
"transcript_support_level": 1,
"aa_start": 444,
"aa_end": null,
"aa_length": 542,
"cds_start": 1330,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265094.9"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1291G>A",
"hgvs_p": "p.Glu431Lys",
"transcript": "ENST00000296933.10",
"protein_id": "ENSP00000296933.6",
"transcript_support_level": 1,
"aa_start": 431,
"aa_end": null,
"aa_length": 529,
"cds_start": 1291,
"cds_end": null,
"cds_length": 1590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000296933.10"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1228G>A",
"hgvs_p": "p.Glu410Lys",
"transcript": "ENST00000393802.6",
"protein_id": "ENSP00000377391.2",
"transcript_support_level": 1,
"aa_start": 410,
"aa_end": null,
"aa_length": 508,
"cds_start": 1228,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393802.6"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1393G>A",
"hgvs_p": "p.Glu465Lys",
"transcript": "ENST00000962353.1",
"protein_id": "ENSP00000632412.1",
"transcript_support_level": null,
"aa_start": 465,
"aa_end": null,
"aa_length": 563,
"cds_start": 1393,
"cds_end": null,
"cds_length": 1692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962353.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1330G>A",
"hgvs_p": "p.Glu444Lys",
"transcript": "NM_012300.3",
"protein_id": "NP_036432.2",
"transcript_support_level": null,
"aa_start": 444,
"aa_end": null,
"aa_length": 542,
"cds_start": 1330,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012300.3"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1330G>A",
"hgvs_p": "p.Glu444Lys",
"transcript": "ENST00000873749.1",
"protein_id": "ENSP00000543808.1",
"transcript_support_level": null,
"aa_start": 444,
"aa_end": null,
"aa_length": 542,
"cds_start": 1330,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000873749.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1324G>A",
"hgvs_p": "p.Glu442Lys",
"transcript": "NM_001378975.1",
"protein_id": "NP_001365904.1",
"transcript_support_level": null,
"aa_start": 442,
"aa_end": null,
"aa_length": 540,
"cds_start": 1324,
"cds_end": null,
"cds_length": 1623,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378975.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1297G>A",
"hgvs_p": "p.Glu433Lys",
"transcript": "NM_001378976.1",
"protein_id": "NP_001365905.1",
"transcript_support_level": null,
"aa_start": 433,
"aa_end": null,
"aa_length": 531,
"cds_start": 1297,
"cds_end": null,
"cds_length": 1596,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378976.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1291G>A",
"hgvs_p": "p.Glu431Lys",
"transcript": "NM_033644.3",
"protein_id": "NP_387448.2",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 529,
"cds_start": 1291,
"cds_end": null,
"cds_length": 1590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_033644.3"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1291G>A",
"hgvs_p": "p.Glu431Lys",
"transcript": "ENST00000873746.1",
"protein_id": "ENSP00000543805.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 529,
"cds_start": 1291,
"cds_end": null,
"cds_length": 1590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000873746.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1291G>A",
"hgvs_p": "p.Glu431Lys",
"transcript": "ENST00000873748.1",
"protein_id": "ENSP00000543807.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 529,
"cds_start": 1291,
"cds_end": null,
"cds_length": 1590,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000873748.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1291G>A",
"hgvs_p": "p.Glu431Lys",
"transcript": "ENST00000940682.1",
"protein_id": "ENSP00000610741.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 528,
"cds_start": 1291,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940682.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1288G>A",
"hgvs_p": "p.Glu430Lys",
"transcript": "ENST00000962351.1",
"protein_id": "ENSP00000632410.1",
"transcript_support_level": null,
"aa_start": 430,
"aa_end": null,
"aa_length": 528,
"cds_start": 1288,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962351.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1234G>A",
"hgvs_p": "p.Glu412Lys",
"transcript": "NM_001378977.1",
"protein_id": "NP_001365906.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 510,
"cds_start": 1234,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378977.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1234G>A",
"hgvs_p": "p.Glu412Lys",
"transcript": "NM_001378978.1",
"protein_id": "NP_001365907.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 510,
"cds_start": 1234,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378978.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1234G>A",
"hgvs_p": "p.Glu412Lys",
"transcript": "NM_001378979.1",
"protein_id": "NP_001365908.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 510,
"cds_start": 1234,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378979.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1228G>A",
"hgvs_p": "p.Glu410Lys",
"transcript": "NM_001378980.1",
"protein_id": "NP_001365909.1",
"transcript_support_level": null,
"aa_start": 410,
"aa_end": null,
"aa_length": 508,
"cds_start": 1228,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378980.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1228G>A",
"hgvs_p": "p.Glu410Lys",
"transcript": "NM_033645.3",
"protein_id": "NP_387449.2",
"transcript_support_level": null,
"aa_start": 410,
"aa_end": null,
"aa_length": 508,
"cds_start": 1228,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_033645.3"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1228G>A",
"hgvs_p": "p.Glu410Lys",
"transcript": "ENST00000873747.1",
"protein_id": "ENSP00000543806.1",
"transcript_support_level": null,
"aa_start": 410,
"aa_end": null,
"aa_length": 508,
"cds_start": 1228,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000873747.1"
},
{
"aa_ref": "E",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FBXW11",
"gene_hgnc_id": 13607,
"hgvs_c": "c.1228G>A",
"hgvs_p": "p.Glu410Lys",
"transcript": "ENST00000962352.1",
"protein_id": "ENSP00000632411.1",
"transcript_support_level": null,
"aa_start": 410,
"aa_end": null,
"aa_length": 508,
"cds_start": 1228,
"cds_end": null,
"cds_length": 1527,
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}
],
"message": null
}