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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-176908564-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=176908564&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 176908564,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_016290.4",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "NM_001199298.2",
"protein_id": "NP_001186227.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 1945,
"cdna_end": null,
"cdna_length": 2574,
"mane_select": "ENST00000511320.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199298.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "ENST00000511320.6",
"protein_id": "ENSP00000421926.1",
"transcript_support_level": 1,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 1945,
"cdna_end": null,
"cdna_length": 2574,
"mane_select": "NM_001199298.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000511320.6"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "ENST00000377227.8",
"protein_id": "ENSP00000366434.4",
"transcript_support_level": 1,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 1940,
"cdna_end": null,
"cdna_length": 2570,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377227.8"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1309A>G",
"hgvs_p": "p.Thr437Ala",
"transcript": "ENST00000506128.5",
"protein_id": "ENSP00000427480.1",
"transcript_support_level": 1,
"aa_start": 437,
"aa_end": null,
"aa_length": 553,
"cds_start": 1309,
"cds_end": null,
"cds_length": 1662,
"cdna_start": 1360,
"cdna_end": null,
"cdna_length": 1945,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000506128.5"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.697A>G",
"hgvs_p": "p.Thr233Ala",
"transcript": "ENST00000510698.2",
"protein_id": "ENSP00000423717.2",
"transcript_support_level": 1,
"aa_start": 233,
"aa_end": null,
"aa_length": 349,
"cds_start": 697,
"cds_end": null,
"cds_length": 1050,
"cdna_start": 765,
"cdna_end": null,
"cdna_length": 1334,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000510698.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "NM_001199297.2",
"protein_id": "NP_001186226.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 2185,
"cdna_end": null,
"cdna_length": 2815,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199297.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "NM_016290.4",
"protein_id": "NP_057374.3",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 1974,
"cdna_end": null,
"cdna_length": 2604,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016290.4"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "ENST00000890107.1",
"protein_id": "ENSP00000560166.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 2069,
"cdna_end": null,
"cdna_length": 2676,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890107.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "ENST00000924857.1",
"protein_id": "ENSP00000594916.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 2136,
"cdna_end": null,
"cdna_length": 2721,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924857.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1549A>G",
"hgvs_p": "p.Thr517Ala",
"transcript": "ENST00000890109.1",
"protein_id": "ENSP00000560168.1",
"transcript_support_level": null,
"aa_start": 517,
"aa_end": null,
"aa_length": 633,
"cds_start": 1549,
"cds_end": null,
"cds_length": 1902,
"cdna_start": 1794,
"cdna_end": null,
"cdna_length": 2369,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890109.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1549A>G",
"hgvs_p": "p.Thr517Ala",
"transcript": "ENST00000924858.1",
"protein_id": "ENSP00000594917.1",
"transcript_support_level": null,
"aa_start": 517,
"aa_end": null,
"aa_length": 633,
"cds_start": 1549,
"cds_end": null,
"cds_length": 1902,
"cdna_start": 1719,
"cdna_end": null,
"cdna_length": 2304,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924858.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1309A>G",
"hgvs_p": "p.Thr437Ala",
"transcript": "NM_001317961.1",
"protein_id": "NP_001304890.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 553,
"cds_start": 1309,
"cds_end": null,
"cds_length": 1662,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 2203,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001317961.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1087A>G",
"hgvs_p": "p.Thr363Ala",
"transcript": "ENST00000970269.1",
"protein_id": "ENSP00000640328.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 479,
"cds_start": 1087,
"cds_end": null,
"cds_length": 1440,
"cdna_start": 1174,
"cdna_end": null,
"cdna_length": 1741,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970269.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.964A>G",
"hgvs_p": "p.Thr322Ala",
"transcript": "ENST00000890105.1",
"protein_id": "ENSP00000560164.1",
"transcript_support_level": null,
"aa_start": 322,
"aa_end": null,
"aa_length": 438,
"cds_start": 964,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 1145,
"cdna_end": null,
"cdna_length": 1743,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890105.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.964A>G",
"hgvs_p": "p.Thr322Ala",
"transcript": "ENST00000890106.1",
"protein_id": "ENSP00000560165.1",
"transcript_support_level": null,
"aa_start": 322,
"aa_end": null,
"aa_length": 438,
"cds_start": 964,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 1102,
"cdna_end": null,
"cdna_length": 4511,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890106.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.964A>G",
"hgvs_p": "p.Thr322Ala",
"transcript": "ENST00000890108.1",
"protein_id": "ENSP00000560167.1",
"transcript_support_level": null,
"aa_start": 322,
"aa_end": null,
"aa_length": 438,
"cds_start": 964,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 1213,
"cdna_end": null,
"cdna_length": 1820,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890108.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.964A>G",
"hgvs_p": "p.Thr322Ala",
"transcript": "ENST00000890110.1",
"protein_id": "ENSP00000560169.1",
"transcript_support_level": null,
"aa_start": 322,
"aa_end": null,
"aa_length": 438,
"cds_start": 964,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 1137,
"cdna_end": null,
"cdna_length": 1736,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890110.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.706A>G",
"hgvs_p": "p.Thr236Ala",
"transcript": "ENST00000970268.1",
"protein_id": "ENSP00000640327.1",
"transcript_support_level": null,
"aa_start": 236,
"aa_end": null,
"aa_length": 352,
"cds_start": 706,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 821,
"cdna_end": null,
"cdna_length": 1406,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970268.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "XM_005265930.3",
"protein_id": "XP_005265987.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 2071,
"cdna_end": null,
"cdna_length": 2701,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005265930.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1807A>G",
"hgvs_p": "p.Thr603Ala",
"transcript": "XM_006714871.3",
"protein_id": "XP_006714934.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 719,
"cds_start": 1807,
"cds_end": null,
"cds_length": 2160,
"cdna_start": 1954,
"cdna_end": null,
"cdna_length": 2584,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006714871.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.1510A>G",
"hgvs_p": "p.Thr504Ala",
"transcript": "XM_047417303.1",
"protein_id": "XP_047273259.1",
"transcript_support_level": null,
"aa_start": 504,
"aa_end": null,
"aa_length": 620,
"cds_start": 1510,
"cds_end": null,
"cds_length": 1863,
"cdna_start": 1663,
"cdna_end": null,
"cdna_length": 2293,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417303.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UIMC1",
"gene_hgnc_id": 30298,
"hgvs_c": "c.964A>G",
"hgvs_p": "p.Thr322Ala",
"transcript": "XM_005265932.4",
"protein_id": "XP_005265989.1",
"transcript_support_level": null,
"aa_start": 322,
"aa_end": null,
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{
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}
],
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}