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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 5-179798929-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=179798929&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "5",
      "pos": 179798929,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant,splice_region_variant",
      "transcript": "NM_054013.3",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1342C>T",
          "hgvs_p": "p.Arg448Trp",
          "transcript": "NM_014275.5",
          "protein_id": "NP_055090.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 548,
          "cds_start": 1342,
          "cds_end": null,
          "cds_length": 1647,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000292591.12",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_014275.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1342C>T",
          "hgvs_p": "p.Arg448Trp",
          "transcript": "ENST00000292591.12",
          "protein_id": "ENSP00000292591.7",
          "transcript_support_level": 1,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 548,
          "cds_start": 1342,
          "cds_end": null,
          "cds_length": 1647,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_014275.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000292591.12"
        },
        {
          "aa_ref": "A",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.944C>T",
          "hgvs_p": "p.Ala315Val",
          "transcript": "ENST00000519836.5",
          "protein_id": "ENSP00000430721.1",
          "transcript_support_level": 1,
          "aa_start": 315,
          "aa_end": null,
          "aa_length": 428,
          "cds_start": 944,
          "cds_end": null,
          "cds_length": 1287,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000519836.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.814C>T",
          "hgvs_p": "p.Arg272Trp",
          "transcript": "ENST00000518778.5",
          "protein_id": "ENSP00000428906.1",
          "transcript_support_level": 1,
          "aa_start": 272,
          "aa_end": null,
          "aa_length": 372,
          "cds_start": 814,
          "cds_end": null,
          "cds_length": 1119,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000518778.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1342C>T",
          "hgvs_p": "p.Arg448Trp",
          "transcript": "ENST00000881425.1",
          "protein_id": "ENSP00000551484.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 575,
          "cds_start": 1342,
          "cds_end": null,
          "cds_length": 1728,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000881425.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1387C>T",
          "hgvs_p": "p.Arg463Trp",
          "transcript": "NM_054013.3",
          "protein_id": "NP_463459.1",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 563,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1692,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_054013.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1387C>T",
          "hgvs_p": "p.Arg463Trp",
          "transcript": "ENST00000337755.9",
          "protein_id": "ENSP00000338487.5",
          "transcript_support_level": 2,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 563,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1692,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000337755.9"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1357C>T",
          "hgvs_p": "p.Arg453Trp",
          "transcript": "ENST00000960973.1",
          "protein_id": "ENSP00000631032.1",
          "transcript_support_level": null,
          "aa_start": 453,
          "aa_end": null,
          "aa_length": 553,
          "cds_start": 1357,
          "cds_end": null,
          "cds_length": 1662,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960973.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1339C>T",
          "hgvs_p": "p.Arg447Trp",
          "transcript": "ENST00000960975.1",
          "protein_id": "ENSP00000631034.1",
          "transcript_support_level": null,
          "aa_start": 447,
          "aa_end": null,
          "aa_length": 544,
          "cds_start": 1339,
          "cds_end": null,
          "cds_length": 1635,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960975.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1339C>T",
          "hgvs_p": "p.Arg447Cys",
          "transcript": "ENST00000960976.1",
          "protein_id": "ENSP00000631035.1",
          "transcript_support_level": null,
          "aa_start": 447,
          "aa_end": null,
          "aa_length": 542,
          "cds_start": 1339,
          "cds_end": null,
          "cds_length": 1629,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960976.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1321C>T",
          "hgvs_p": "p.Arg441Trp",
          "transcript": "ENST00000960972.1",
          "protein_id": "ENSP00000631031.1",
          "transcript_support_level": null,
          "aa_start": 441,
          "aa_end": null,
          "aa_length": 541,
          "cds_start": 1321,
          "cds_end": null,
          "cds_length": 1626,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960972.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1282C>T",
          "hgvs_p": "p.Arg428Trp",
          "transcript": "ENST00000881423.1",
          "protein_id": "ENSP00000551482.1",
          "transcript_support_level": null,
          "aa_start": 428,
          "aa_end": null,
          "aa_length": 528,
          "cds_start": 1282,
          "cds_end": null,
          "cds_length": 1587,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000881423.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1234C>T",
          "hgvs_p": "p.Arg412Trp",
          "transcript": "ENST00000960974.1",
          "protein_id": "ENSP00000631033.1",
          "transcript_support_level": null,
          "aa_start": 412,
          "aa_end": null,
          "aa_length": 512,
          "cds_start": 1234,
          "cds_end": null,
          "cds_length": 1539,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960974.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1228C>T",
          "hgvs_p": "p.Arg410Trp",
          "transcript": "ENST00000881424.1",
          "protein_id": "ENSP00000551483.1",
          "transcript_support_level": null,
          "aa_start": 410,
          "aa_end": null,
          "aa_length": 510,
          "cds_start": 1228,
          "cds_end": null,
          "cds_length": 1533,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000881424.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.1183C>T",
          "hgvs_p": "p.Arg395Trp",
          "transcript": "ENST00000881426.1",
          "protein_id": "ENSP00000551485.1",
          "transcript_support_level": null,
          "aa_start": 395,
          "aa_end": null,
          "aa_length": 495,
          "cds_start": 1183,
          "cds_end": null,
          "cds_length": 1488,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000881426.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.682C>T",
          "hgvs_p": "p.Arg228Trp",
          "transcript": "ENST00000520875.5",
          "protein_id": "ENSP00000430723.1",
          "transcript_support_level": 5,
          "aa_start": 228,
          "aa_end": null,
          "aa_length": 320,
          "cds_start": 682,
          "cds_end": null,
          "cds_length": 963,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000520875.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.578C>T",
          "hgvs_p": "p.Ala193Val",
          "transcript": "ENST00000518980.5",
          "protein_id": "ENSP00000431093.1",
          "transcript_support_level": 5,
          "aa_start": 193,
          "aa_end": null,
          "aa_length": 306,
          "cds_start": 578,
          "cds_end": null,
          "cds_length": 921,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000518980.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "C",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.430C>T",
          "hgvs_p": "p.Arg144Cys",
          "transcript": "ENST00000520969.5",
          "protein_id": "ENSP00000428960.1",
          "transcript_support_level": 3,
          "aa_start": 144,
          "aa_end": null,
          "aa_length": 239,
          "cds_start": 430,
          "cds_end": null,
          "cds_length": 720,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000520969.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.907C>T",
          "hgvs_p": "p.Arg303Trp",
          "transcript": "XM_024454349.2",
          "protein_id": "XP_024310117.1",
          "transcript_support_level": null,
          "aa_start": 303,
          "aa_end": null,
          "aa_length": 403,
          "cds_start": 907,
          "cds_end": null,
          "cds_length": 1212,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024454349.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "c.639+136C>T",
          "hgvs_p": null,
          "transcript": "ENST00000518867.5",
          "protein_id": "ENSP00000428764.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 242,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 731,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000518867.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "n.372C>T",
          "hgvs_p": null,
          "transcript": "ENST00000522293.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000522293.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "n.513+136C>T",
          "hgvs_p": null,
          "transcript": "ENST00000523382.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000523382.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MGAT4B",
          "gene_hgnc_id": 7048,
          "hgvs_c": "n.-94C>T",
          "hgvs_p": null,
          "transcript": "ENST00000522451.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000522451.5"
        }
      ],
      "gene_symbol": "MGAT4B",
      "gene_hgnc_id": 7048,
      "dbsnp": "rs149772768",
      "frequency_reference_population": 0.000021693964,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 35,
      "gnomad_exomes_af": 0.0000225855,
      "gnomad_genomes_af": 0.0000131375,
      "gnomad_exomes_ac": 33,
      "gnomad_genomes_ac": 2,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.7406377792358398,
      "computational_prediction_selected": "Uncertain_significance",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.33399999141693115,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "dbscSNV1_RF",
      "revel_score": 0.253,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.5439,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.04,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 2.581,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.06,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": 0.011259343575331,
      "dbscsnv_ada_prediction": "Benign",
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 2,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2",
      "acmg_by_gene": [
        {
          "score": 2,
          "benign_score": 0,
          "pathogenic_score": 2,
          "criteria": [
            "PM2"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_054013.3",
          "gene_symbol": "MGAT4B",
          "hgnc_id": 7048,
          "effects": [
            "missense_variant",
            "splice_region_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1387C>T",
          "hgvs_p": "p.Arg463Trp"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}