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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-39219513-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=39219513&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 39219513,
"ref": "T",
"alt": "A",
"effect": "5_prime_UTR_premature_start_codon_gain_variant",
"transcript": "ENST00000512982.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "NM_001465.6",
"protein_id": "NP_001456.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 829,
"cds_start": -4,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4829,
"mane_select": "ENST00000512982.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "ENST00000512982.4",
"protein_id": "ENSP00000425845.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 829,
"cds_start": -4,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4829,
"mane_select": "NM_001465.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "ENST00000351578.12",
"protein_id": "ENSP00000316460.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 783,
"cds_start": -4,
"cds_end": null,
"cds_length": 2352,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4691,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "NM_001465.6",
"protein_id": "NP_001456.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 829,
"cds_start": -4,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4829,
"mane_select": "ENST00000512982.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "ENST00000512982.4",
"protein_id": "ENSP00000425845.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 829,
"cds_start": -4,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4829,
"mane_select": "NM_001465.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "ENST00000351578.12",
"protein_id": "ENSP00000316460.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 783,
"cds_start": -4,
"cds_end": null,
"cds_length": 2352,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4691,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-438A>T",
"hgvs_p": null,
"transcript": "NM_001349333.2",
"protein_id": "NP_001336262.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 829,
"cds_start": -4,
"cds_end": null,
"cds_length": 2490,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5169,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-169A>T",
"hgvs_p": null,
"transcript": "NM_018594.2",
"protein_id": "NP_061064.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 793,
"cds_start": -4,
"cds_end": null,
"cds_length": 2382,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4792,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "NM_199335.5",
"protein_id": "NP_955367.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 783,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-438A>T",
"hgvs_p": null,
"transcript": "ENST00000506557.5",
"protein_id": "ENSP00000421988.2",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 61,
"cds_start": -4,
"cds_end": null,
"cds_length": 187,
"cdna_start": null,
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"cdna_length": 688,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-472A>T",
"hgvs_p": null,
"transcript": "ENST00000509072.5",
"protein_id": "ENSP00000423888.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
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"exon_count": 4,
"intron_rank": null,
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"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-539A>T",
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"transcript": "ENST00000504542.1",
"protein_id": "ENSP00000420989.1",
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"aa_start": null,
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"aa_length": 0,
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"biotype": null,
"feature": null
},
{
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"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
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"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-509A>T",
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"transcript": "XM_011514008.3",
"protein_id": "XP_011512310.1",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "FYB1",
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},
{
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"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
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"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-438A>T",
"hgvs_p": null,
"transcript": "NM_001349333.2",
"protein_id": "NP_001336262.1",
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"aa_start": null,
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},
{
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"strand": false,
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],
"exon_rank": 1,
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"exon_count": 19,
"intron_rank": null,
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"gene_symbol": "FYB1",
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"hgvs_c": "c.-169A>T",
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},
{
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"protein_coding": true,
"strand": false,
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],
"exon_rank": 1,
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"exon_count": 18,
"intron_rank": null,
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"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-98A>T",
"hgvs_p": null,
"transcript": "NM_199335.5",
"protein_id": "NP_955367.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-438A>T",
"hgvs_p": null,
"transcript": "ENST00000506557.5",
"protein_id": "ENSP00000421988.2",
"transcript_support_level": 4,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 1,
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"intron_rank": null,
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"gene_symbol": "FYB1",
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"transcript": "ENST00000509072.5",
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},
{
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],
"exon_rank": 1,
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"intron_rank": null,
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"gene_symbol": "FYB1",
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"hgvs_c": "c.-539A>T",
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"transcript": "ENST00000504542.1",
"protein_id": "ENSP00000420989.1",
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},
{
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"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "FYB1",
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"hgvs_c": "c.-509A>T",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.-472A>T",
"hgvs_p": null,
"transcript": "XM_011514009.1",
"protein_id": "XP_011512311.1",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FYB1",
"gene_hgnc_id": 4036,
"hgvs_c": "c.4-16526A>T",
"hgvs_p": null,
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}