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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-43157320-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=43157320&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 43157320,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000682664.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330707.2",
"protein_id": "NP_001317636.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3286,
"mane_select": "ENST00000682664.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "ENST00000682664.1",
"protein_id": "ENSP00000507111.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3286,
"mane_select": "NM_001330707.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "ENST00000515326.5",
"protein_id": "ENSP00000422079.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 263,
"cds_start": -4,
"cds_end": null,
"cds_length": 794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "n.227-3929A>G",
"hgvs_p": null,
"transcript": "ENST00000507218.5",
"protein_id": "ENSP00000425139.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1352,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "n.372-15998A>G",
"hgvs_p": null,
"transcript": "ENST00000511736.5",
"protein_id": "ENSP00000426614.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 956,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "NM_001297548.3",
"protein_id": "NP_001284477.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3691,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330708.2",
"protein_id": "NP_001317637.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3281,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330712.2",
"protein_id": "NP_001317641.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330714.2",
"protein_id": "NP_001317643.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
"cds_end": null,
"cds_length": 1872,
"cdna_start": null,
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"cdna_length": 3340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "ENST00000509156.5",
"protein_id": "ENSP00000426504.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 623,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330706.2",
"protein_id": "NP_001317635.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
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"gene_symbol": "ZNF131",
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"hgvs_c": "c.372-3929A>G",
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"transcript": "NM_001330711.2",
"protein_id": "NP_001317640.1",
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},
{
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"strand": true,
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],
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"intron_rank": 4,
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"gene_symbol": "ZNF131",
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"hgvs_c": "c.372-3929A>G",
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"transcript": "NM_001330713.2",
"protein_id": "NP_001317642.1",
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"aa_start": null,
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},
{
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"strand": true,
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],
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"gene_symbol": "ZNF131",
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"hgvs_c": "c.372-3929A>G",
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"transcript": "NM_001330715.2",
"protein_id": "NP_001317644.1",
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},
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],
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"gene_symbol": "ZNF131",
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"transcript": "NM_001388319.1",
"protein_id": "NP_001375248.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "ZNF131",
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"hgvs_c": "c.372-3929A>G",
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"transcript": "NM_003432.4",
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},
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],
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"gene_symbol": "ZNF131",
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"hgvs_c": "c.372-3929A>G",
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"transcript": "ENST00000306938.8",
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},
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],
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"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.372-3929A>G",
"hgvs_p": null,
"transcript": "ENST00000505606.6",
"protein_id": "ENSP00000423945.1",
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},
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],
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"gene_symbol": "ZNF131",
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"transcript": "ENST00000509634.5",
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"gene_symbol": "ZNF131",
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],
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.-371-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330704.2",
"protein_id": "NP_001317633.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZNF131",
"gene_hgnc_id": 12915,
"hgvs_c": "c.-466-3929A>G",
"hgvs_p": null,
"transcript": "NM_001330705.1",
"protein_id": "NP_001317634.1",
"transcript_support_level": null,
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}
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}