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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-67156347-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=67156347&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 67156347,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001393524.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3648+2767G>C",
"hgvs_p": null,
"transcript": "NM_001164664.2",
"protein_id": "NP_001158136.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2623,
"cds_start": null,
"cds_end": null,
"cds_length": 7872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000403625.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164664.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3648+2767G>C",
"hgvs_p": null,
"transcript": "ENST00000403625.7",
"protein_id": "ENSP00000385727.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2623,
"cds_start": null,
"cds_end": null,
"cds_length": 7872,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001164664.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000403625.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3081+2767G>C",
"hgvs_p": null,
"transcript": "ENST00000403666.5",
"protein_id": "ENSP00000384313.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 2434,
"cds_start": null,
"cds_end": null,
"cds_length": 7305,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000403666.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.816+2767G>C",
"hgvs_p": null,
"transcript": "ENST00000443808.1",
"protein_id": "ENSP00000400551.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1679,
"cds_start": null,
"cds_end": null,
"cds_length": 5040,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000443808.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3657+2767G>C",
"hgvs_p": null,
"transcript": "NM_001393524.1",
"protein_id": "NP_001380453.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2626,
"cds_start": null,
"cds_end": null,
"cds_length": 7881,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393524.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3447+2767G>C",
"hgvs_p": null,
"transcript": "NM_001393525.1",
"protein_id": "NP_001380454.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2556,
"cds_start": null,
"cds_end": null,
"cds_length": 7671,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393525.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3111+2767G>C",
"hgvs_p": null,
"transcript": "ENST00000405643.5",
"protein_id": "ENSP00000384099.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2444,
"cds_start": null,
"cds_end": null,
"cds_length": 7335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405643.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3081+2767G>C",
"hgvs_p": null,
"transcript": "NM_015183.3",
"protein_id": "NP_055998.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2434,
"cds_start": null,
"cds_end": null,
"cds_length": 7305,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015183.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3066+2767G>C",
"hgvs_p": null,
"transcript": "NM_001297651.2",
"protein_id": "NP_001284580.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2429,
"cds_start": null,
"cds_end": null,
"cds_length": 7290,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001297651.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3066+2767G>C",
"hgvs_p": null,
"transcript": "ENST00000261569.11",
"protein_id": "ENSP00000261569.7",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2429,
"cds_start": null,
"cds_end": null,
"cds_length": 7290,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000261569.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3030+2767G>C",
"hgvs_p": null,
"transcript": "NM_001290226.2",
"protein_id": "NP_001277155.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2417,
"cds_start": null,
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"cds_length": 7254,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001290226.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.2880+2767G>C",
"hgvs_p": null,
"transcript": "NM_001393526.1",
"protein_id": "NP_001380455.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2367,
"cds_start": null,
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"cds_length": 7104,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393526.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.2865+2767G>C",
"hgvs_p": null,
"transcript": "NM_001290227.2",
"protein_id": "NP_001277156.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2362,
"cds_start": null,
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"cds_length": 7089,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001290227.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 22,
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"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.2865+2767G>C",
"hgvs_p": null,
"transcript": "NM_001393527.1",
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "NM_001393527.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.2844+2767G>C",
"hgvs_p": null,
"transcript": "NM_001393528.1",
"protein_id": "NP_001380457.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2355,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393528.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 33,
"intron_rank": 30,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3864+2767G>C",
"hgvs_p": null,
"transcript": "XM_024446044.2",
"protein_id": "XP_024301812.1",
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"biotype": "protein_coding",
"feature": "XM_024446044.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3684+2767G>C",
"hgvs_p": null,
"transcript": "XM_047417157.1",
"protein_id": "XP_047273113.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047417157.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3483+2767G>C",
"hgvs_p": null,
"transcript": "XM_047417158.1",
"protein_id": "XP_047273114.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "XM_047417158.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3312+2767G>C",
"hgvs_p": null,
"transcript": "XM_047417159.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3147+2767G>C",
"hgvs_p": null,
"transcript": "XM_047417160.1",
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"feature": "XM_047417160.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3102+2767G>C",
"hgvs_p": null,
"transcript": "XM_017009449.2",
"protein_id": "XP_016864938.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017009449.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.3066+2767G>C",
"hgvs_p": null,
"transcript": "XM_006714606.4",
"protein_id": "XP_006714669.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006714606.4"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
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}