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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-67166241-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=67166241&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 67166241,
"ref": "A",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000403625.7",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.7062A>T",
"hgvs_p": "p.Thr2354Thr",
"transcript": "NM_001164664.2",
"protein_id": "NP_001158136.1",
"transcript_support_level": null,
"aa_start": 2354,
"aa_end": null,
"aa_length": 2623,
"cds_start": 7062,
"cds_end": null,
"cds_length": 7872,
"cdna_start": 7325,
"cdna_end": null,
"cdna_length": 10677,
"mane_select": "ENST00000403625.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.7062A>T",
"hgvs_p": "p.Thr2354Thr",
"transcript": "ENST00000403625.7",
"protein_id": "ENSP00000385727.1",
"transcript_support_level": 5,
"aa_start": 2354,
"aa_end": null,
"aa_length": 2623,
"cds_start": 7062,
"cds_end": null,
"cds_length": 7872,
"cdna_start": 7325,
"cdna_end": null,
"cdna_length": 10677,
"mane_select": "NM_001164664.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6495A>T",
"hgvs_p": "p.Thr2165Thr",
"transcript": "ENST00000403666.5",
"protein_id": "ENSP00000384313.1",
"transcript_support_level": 1,
"aa_start": 2165,
"aa_end": null,
"aa_length": 2434,
"cds_start": 6495,
"cds_end": null,
"cds_length": 7305,
"cdna_start": 6563,
"cdna_end": null,
"cdna_length": 7586,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.4230A>T",
"hgvs_p": "p.Thr1410Thr",
"transcript": "ENST00000443808.1",
"protein_id": "ENSP00000400551.1",
"transcript_support_level": 1,
"aa_start": 1410,
"aa_end": null,
"aa_length": 1679,
"cds_start": 4230,
"cds_end": null,
"cds_length": 5040,
"cdna_start": 4231,
"cdna_end": null,
"cdna_length": 5273,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.7071A>T",
"hgvs_p": "p.Thr2357Thr",
"transcript": "NM_001393524.1",
"protein_id": "NP_001380453.1",
"transcript_support_level": null,
"aa_start": 2357,
"aa_end": null,
"aa_length": 2626,
"cds_start": 7071,
"cds_end": null,
"cds_length": 7881,
"cdna_start": 7334,
"cdna_end": null,
"cdna_length": 10686,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6861A>T",
"hgvs_p": "p.Thr2287Thr",
"transcript": "NM_001393525.1",
"protein_id": "NP_001380454.1",
"transcript_support_level": null,
"aa_start": 2287,
"aa_end": null,
"aa_length": 2556,
"cds_start": 6861,
"cds_end": null,
"cds_length": 7671,
"cdna_start": 7124,
"cdna_end": null,
"cdna_length": 10476,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6525A>T",
"hgvs_p": "p.Thr2175Thr",
"transcript": "ENST00000405643.5",
"protein_id": "ENSP00000384099.1",
"transcript_support_level": 5,
"aa_start": 2175,
"aa_end": null,
"aa_length": 2444,
"cds_start": 6525,
"cds_end": null,
"cds_length": 7335,
"cdna_start": 6903,
"cdna_end": null,
"cdna_length": 7713,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6495A>T",
"hgvs_p": "p.Thr2165Thr",
"transcript": "NM_015183.3",
"protein_id": "NP_055998.1",
"transcript_support_level": null,
"aa_start": 2165,
"aa_end": null,
"aa_length": 2434,
"cds_start": 6495,
"cds_end": null,
"cds_length": 7305,
"cdna_start": 6566,
"cdna_end": null,
"cdna_length": 9918,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6480A>T",
"hgvs_p": "p.Thr2160Thr",
"transcript": "NM_001297651.2",
"protein_id": "NP_001284580.1",
"transcript_support_level": null,
"aa_start": 2160,
"aa_end": null,
"aa_length": 2429,
"cds_start": 6480,
"cds_end": null,
"cds_length": 7290,
"cdna_start": 6819,
"cdna_end": null,
"cdna_length": 10171,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6480A>T",
"hgvs_p": "p.Thr2160Thr",
"transcript": "ENST00000261569.11",
"protein_id": "ENSP00000261569.7",
"transcript_support_level": 5,
"aa_start": 2160,
"aa_end": null,
"aa_length": 2429,
"cds_start": 6480,
"cds_end": null,
"cds_length": 7290,
"cdna_start": 6854,
"cdna_end": null,
"cdna_length": 7664,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6444A>T",
"hgvs_p": "p.Thr2148Thr",
"transcript": "NM_001290226.2",
"protein_id": "NP_001277155.1",
"transcript_support_level": null,
"aa_start": 2148,
"aa_end": null,
"aa_length": 2417,
"cds_start": 6444,
"cds_end": null,
"cds_length": 7254,
"cdna_start": 6619,
"cdna_end": null,
"cdna_length": 9971,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6294A>T",
"hgvs_p": "p.Thr2098Thr",
"transcript": "NM_001393526.1",
"protein_id": "NP_001380455.1",
"transcript_support_level": null,
"aa_start": 2098,
"aa_end": null,
"aa_length": 2367,
"cds_start": 6294,
"cds_end": null,
"cds_length": 7104,
"cdna_start": 6365,
"cdna_end": null,
"cdna_length": 9717,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6279A>T",
"hgvs_p": "p.Thr2093Thr",
"transcript": "NM_001290227.2",
"protein_id": "NP_001277156.1",
"transcript_support_level": null,
"aa_start": 2093,
"aa_end": null,
"aa_length": 2362,
"cds_start": 6279,
"cds_end": null,
"cds_length": 7089,
"cdna_start": 6358,
"cdna_end": null,
"cdna_length": 9710,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6279A>T",
"hgvs_p": "p.Thr2093Thr",
"transcript": "NM_001393527.1",
"protein_id": "NP_001380456.1",
"transcript_support_level": null,
"aa_start": 2093,
"aa_end": null,
"aa_length": 2362,
"cds_start": 6279,
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"cdna_start": 6618,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6258A>T",
"hgvs_p": "p.Thr2086Thr",
"transcript": "NM_001393528.1",
"protein_id": "NP_001380457.1",
"transcript_support_level": null,
"aa_start": 2086,
"aa_end": null,
"aa_length": 2355,
"cds_start": 6258,
"cds_end": null,
"cds_length": 7068,
"cdna_start": 6329,
"cdna_end": null,
"cdna_length": 9681,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.7278A>T",
"hgvs_p": "p.Thr2426Thr",
"transcript": "XM_024446044.2",
"protein_id": "XP_024301812.1",
"transcript_support_level": null,
"aa_start": 2426,
"aa_end": null,
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"cds_start": 7278,
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"cdna_start": 7541,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.7098A>T",
"hgvs_p": "p.Thr2366Thr",
"transcript": "XM_047417157.1",
"protein_id": "XP_047273113.1",
"transcript_support_level": null,
"aa_start": 2366,
"aa_end": null,
"aa_length": 2635,
"cds_start": 7098,
"cds_end": null,
"cds_length": 7908,
"cdna_start": 7361,
"cdna_end": null,
"cdna_length": 10713,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6897A>T",
"hgvs_p": "p.Thr2299Thr",
"transcript": "XM_047417158.1",
"protein_id": "XP_047273114.1",
"transcript_support_level": null,
"aa_start": 2299,
"aa_end": null,
"aa_length": 2568,
"cds_start": 6897,
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"cdna_start": 7160,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6726A>T",
"hgvs_p": "p.Thr2242Thr",
"transcript": "XM_047417159.1",
"protein_id": "XP_047273115.1",
"transcript_support_level": null,
"aa_start": 2242,
"aa_end": null,
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"cds_start": 6726,
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"cdna_start": 7997,
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"cdna_length": 11349,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6561A>T",
"hgvs_p": "p.Thr2187Thr",
"transcript": "XM_047417160.1",
"protein_id": "XP_047273116.1",
"transcript_support_level": null,
"aa_start": 2187,
"aa_end": null,
"aa_length": 2456,
"cds_start": 6561,
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"cdna_start": 7831,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6516A>T",
"hgvs_p": "p.Thr2172Thr",
"transcript": "XM_017009449.2",
"protein_id": "XP_016864938.1",
"transcript_support_level": null,
"aa_start": 2172,
"aa_end": null,
"aa_length": 2441,
"cds_start": 6516,
"cds_end": null,
"cds_length": 7326,
"cdna_start": 6691,
"cdna_end": null,
"cdna_length": 10043,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAST4",
"gene_hgnc_id": 19037,
"hgvs_c": "c.6480A>T",
"hgvs_p": "p.Thr2160Thr",
"transcript": "XM_006714606.4",
"protein_id": "XP_006714669.1",
"transcript_support_level": null,
"aa_start": 2160,
"aa_end": null,
"aa_length": 2429,
"cds_start": 6480,
"cds_end": null,
"cds_length": 7290,
"cdna_start": 6559,
"cdna_end": null,
"cdna_length": 9911,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
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}
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}