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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-69175448-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=69175448&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 69175448,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_031966.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.994T>C",
"hgvs_p": "p.Leu332Leu",
"transcript": "NM_031966.4",
"protein_id": "NP_114172.1",
"transcript_support_level": null,
"aa_start": 332,
"aa_end": null,
"aa_length": 433,
"cds_start": 994,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 1107,
"cdna_end": null,
"cdna_length": 2029,
"mane_select": "ENST00000256442.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_031966.4"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.994T>C",
"hgvs_p": "p.Leu332Leu",
"transcript": "ENST00000256442.10",
"protein_id": "ENSP00000256442.5",
"transcript_support_level": 1,
"aa_start": 332,
"aa_end": null,
"aa_length": 433,
"cds_start": 994,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 1107,
"cdna_end": null,
"cdna_length": 2029,
"mane_select": "NM_031966.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000256442.10"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.994T>C",
"hgvs_p": "p.Leu332Leu",
"transcript": "ENST00000506572.5",
"protein_id": "ENSP00000423387.1",
"transcript_support_level": 1,
"aa_start": 332,
"aa_end": null,
"aa_length": 400,
"cds_start": 994,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1122,
"cdna_end": null,
"cdna_length": 1331,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000506572.5"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.994T>C",
"hgvs_p": "p.Leu332Leu",
"transcript": "ENST00000505500.5",
"protein_id": "ENSP00000424588.1",
"transcript_support_level": 1,
"aa_start": 332,
"aa_end": null,
"aa_length": 395,
"cds_start": 994,
"cds_end": null,
"cds_length": 1190,
"cdna_start": 994,
"cdna_end": null,
"cdna_length": 1190,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000505500.5"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.1012T>C",
"hgvs_p": "p.Leu338Leu",
"transcript": "ENST00000870642.1",
"protein_id": "ENSP00000540701.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 439,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1320,
"cdna_start": 1146,
"cdna_end": null,
"cdna_length": 1517,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870642.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.1009T>C",
"hgvs_p": "p.Leu337Leu",
"transcript": "ENST00000924410.1",
"protein_id": "ENSP00000594469.1",
"transcript_support_level": null,
"aa_start": 337,
"aa_end": null,
"aa_length": 438,
"cds_start": 1009,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 1143,
"cdna_end": null,
"cdna_length": 2065,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924410.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.1000T>C",
"hgvs_p": "p.Leu334Leu",
"transcript": "ENST00000924409.1",
"protein_id": "ENSP00000594468.1",
"transcript_support_level": null,
"aa_start": 334,
"aa_end": null,
"aa_length": 435,
"cds_start": 1000,
"cds_end": null,
"cds_length": 1308,
"cdna_start": 1140,
"cdna_end": null,
"cdna_length": 2063,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924409.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.994T>C",
"hgvs_p": "p.Leu332Leu",
"transcript": "ENST00000924413.1",
"protein_id": "ENSP00000594472.1",
"transcript_support_level": null,
"aa_start": 332,
"aa_end": null,
"aa_length": 433,
"cds_start": 994,
"cds_end": null,
"cds_length": 1302,
"cdna_start": 1096,
"cdna_end": null,
"cdna_length": 1470,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924413.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.988T>C",
"hgvs_p": "p.Leu330Leu",
"transcript": "ENST00000924408.1",
"protein_id": "ENSP00000594467.1",
"transcript_support_level": null,
"aa_start": 330,
"aa_end": null,
"aa_length": 431,
"cds_start": 988,
"cds_end": null,
"cds_length": 1296,
"cdna_start": 1134,
"cdna_end": null,
"cdna_length": 2056,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924408.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.922T>C",
"hgvs_p": "p.Leu308Leu",
"transcript": "ENST00000924422.1",
"protein_id": "ENSP00000594481.1",
"transcript_support_level": null,
"aa_start": 308,
"aa_end": null,
"aa_length": 409,
"cds_start": 922,
"cds_end": null,
"cds_length": 1230,
"cdna_start": 1030,
"cdna_end": null,
"cdna_length": 1400,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924422.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.886T>C",
"hgvs_p": "p.Leu296Leu",
"transcript": "ENST00000924407.1",
"protein_id": "ENSP00000594466.1",
"transcript_support_level": null,
"aa_start": 296,
"aa_end": null,
"aa_length": 397,
"cds_start": 886,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 1145,
"cdna_end": null,
"cdna_length": 2194,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924407.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.994T>C",
"hgvs_p": "p.Leu332Leu",
"transcript": "NM_001354844.2",
"protein_id": "NP_001341773.1",
"transcript_support_level": null,
"aa_start": 332,
"aa_end": null,
"aa_length": 396,
"cds_start": 994,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 1107,
"cdna_end": null,
"cdna_length": 1918,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354844.2"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.853T>C",
"hgvs_p": "p.Leu285Leu",
"transcript": "ENST00000924420.1",
"protein_id": "ENSP00000594479.1",
"transcript_support_level": null,
"aa_start": 285,
"aa_end": null,
"aa_length": 386,
"cds_start": 853,
"cds_end": null,
"cds_length": 1161,
"cdna_start": 966,
"cdna_end": null,
"cdna_length": 1343,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924420.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.835T>C",
"hgvs_p": "p.Leu279Leu",
"transcript": "NM_001354845.2",
"protein_id": "NP_001341774.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 380,
"cds_start": 835,
"cds_end": null,
"cds_length": 1143,
"cdna_start": 948,
"cdna_end": null,
"cdna_length": 1870,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001354845.2"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.823T>C",
"hgvs_p": "p.Leu275Leu",
"transcript": "ENST00000924416.1",
"protein_id": "ENSP00000594475.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 376,
"cds_start": 823,
"cds_end": null,
"cds_length": 1131,
"cdna_start": 935,
"cdna_end": null,
"cdna_length": 1368,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924416.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.733T>C",
"hgvs_p": "p.Leu245Leu",
"transcript": "ENST00000924418.1",
"protein_id": "ENSP00000594477.1",
"transcript_support_level": null,
"aa_start": 245,
"aa_end": null,
"aa_length": 346,
"cds_start": 733,
"cds_end": null,
"cds_length": 1041,
"cdna_start": 847,
"cdna_end": null,
"cdna_length": 1270,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924418.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.652T>C",
"hgvs_p": "p.Leu218Leu",
"transcript": "ENST00000924417.1",
"protein_id": "ENSP00000594476.1",
"transcript_support_level": null,
"aa_start": 218,
"aa_end": null,
"aa_length": 319,
"cds_start": 652,
"cds_end": null,
"cds_length": 960,
"cdna_start": 765,
"cdna_end": null,
"cdna_length": 1194,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924417.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.598T>C",
"hgvs_p": "p.Leu200Leu",
"transcript": "ENST00000924415.1",
"protein_id": "ENSP00000594474.1",
"transcript_support_level": null,
"aa_start": 200,
"aa_end": null,
"aa_length": 301,
"cds_start": 598,
"cds_end": null,
"cds_length": 906,
"cdna_start": 731,
"cdna_end": null,
"cdna_length": 1161,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924415.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.544T>C",
"hgvs_p": "p.Leu182Leu",
"transcript": "ENST00000960692.1",
"protein_id": "ENSP00000630751.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 283,
"cds_start": 544,
"cds_end": null,
"cds_length": 852,
"cdna_start": 556,
"cdna_end": null,
"cdna_length": 930,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960692.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.415T>C",
"hgvs_p": "p.Leu139Leu",
"transcript": "ENST00000924412.1",
"protein_id": "ENSP00000594471.1",
"transcript_support_level": null,
"aa_start": 139,
"aa_end": null,
"aa_length": 240,
"cds_start": 415,
"cds_end": null,
"cds_length": 723,
"cdna_start": 530,
"cdna_end": null,
"cdna_length": 1446,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924412.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.442T>C",
"hgvs_p": "p.Leu148Leu",
"transcript": "ENST00000507798.1",
"protein_id": "ENSP00000426230.1",
"transcript_support_level": 3,
"aa_start": 148,
"aa_end": null,
"aa_length": 185,
"cds_start": 442,
"cds_end": null,
"cds_length": 558,
"cdna_start": 442,
"cdna_end": null,
"cdna_length": 767,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000507798.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "CCNB1",
"gene_hgnc_id": 1579,
"hgvs_c": "c.942+335T>C",
"hgvs_p": null,
"transcript": "ENST00000924414.1",
"protein_id": "ENSP00000594473.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": null,
"cds_end": null,
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}
],
"message": null
}