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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-69413682-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=69413682&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 69413682,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000354868.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "NM_133338.3",
"protein_id": "NP_579916.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3054,
"mane_select": "ENST00000354868.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "ENST00000354868.10",
"protein_id": "ENSP00000346938.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3054,
"mane_select": "NM_133338.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1785-349G>A",
"hgvs_p": null,
"transcript": "ENST00000380774.7",
"protein_id": "ENSP00000370151.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 681,
"cds_start": -4,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2117,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "ENST00000305138.8",
"protein_id": "ENSP00000303134.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3164,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "ENST00000345306.10",
"protein_id": "ENSP00000311227.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2789,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "ENST00000354312.7",
"protein_id": "ENSP00000346271.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2943,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "ENST00000361732.6",
"protein_id": "ENSP00000355226.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3002,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "ENST00000616683.4",
"protein_id": "ENSP00000482775.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 670,
"cds_start": -4,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3057,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1494-349G>A",
"hgvs_p": null,
"transcript": "ENST00000282891.10",
"protein_id": "ENSP00000282891.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 584,
"cds_start": -4,
"cds_end": null,
"cds_length": 1755,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2135,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1257-349G>A",
"hgvs_p": null,
"transcript": "ENST00000358030.6",
"protein_id": "ENSP00000350725.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 505,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2648,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1785-349G>A",
"hgvs_p": null,
"transcript": "NM_133339.2",
"protein_id": "NP_579917.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 18,
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"gene_symbol": "RAD17",
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"hgvs_c": "c.1785-349G>A",
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"transcript": "ENST00000509734.5",
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},
{
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"consequences": [
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],
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"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "NM_001278622.1",
"protein_id": "NP_001265551.1",
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "RAD17",
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"hgvs_c": "c.1752-349G>A",
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"transcript": "NM_002873.1",
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},
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],
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"gene_symbol": "RAD17",
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"hgvs_c": "c.1752-349G>A",
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"transcript": "NM_133342.3",
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 17,
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"gene_symbol": "RAD17",
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"hgvs_c": "c.1752-349G>A",
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"transcript": "NM_133343.2",
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},
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],
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"gene_symbol": "RAD17",
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"transcript": "NM_133344.3",
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},
{
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"consequences": [
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],
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"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1494-349G>A",
"hgvs_p": null,
"transcript": "NM_133341.2",
"protein_id": "NP_579919.1",
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 15,
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"gene_symbol": "RAD17",
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"hgvs_c": "c.1257-349G>A",
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"transcript": "NM_133340.2",
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},
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],
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},
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],
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"gene_symbol": "RAD17",
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},
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"strand": true,
"consequences": [
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],
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"intron_rank": 3,
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"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "n.288-349G>A",
"hgvs_p": null,
"transcript": "ENST00000504177.5",
"protein_id": null,
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"feature": null
},
{
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"protein_coding": true,
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"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "RAD17",
"gene_hgnc_id": 9807,
"hgvs_c": "c.1752-349G>A",
"hgvs_p": null,
"transcript": "XM_017009681.2",
"protein_id": "XP_016865170.1",
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},
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}
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}