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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-850572-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=850572&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 850572,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001393492.1",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "NM_024786.3",
"protein_id": "NP_079062.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 412,
"cds_start": 31,
"cds_end": null,
"cds_length": 1239,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000283441.13",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_024786.3"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "ENST00000283441.13",
"protein_id": "ENSP00000283441.8",
"transcript_support_level": 1,
"aa_start": 11,
"aa_end": null,
"aa_length": 412,
"cds_start": 31,
"cds_end": null,
"cds_length": 1239,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_024786.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000283441.13"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "NM_001393492.1",
"protein_id": "NP_001380421.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 467,
"cds_start": 31,
"cds_end": null,
"cds_length": 1404,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001393492.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "ENST00000685990.1",
"protein_id": "ENSP00000509570.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 153,
"cds_start": 31,
"cds_end": null,
"cds_length": 464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000685990.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446209.2",
"protein_id": "XP_024301977.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 510,
"cds_start": 31,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446209.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417746.1",
"protein_id": "XP_047273702.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 510,
"cds_start": 31,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417746.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417747.1",
"protein_id": "XP_047273703.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 510,
"cds_start": 31,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417747.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417748.1",
"protein_id": "XP_047273704.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 471,
"cds_start": 31,
"cds_end": null,
"cds_length": 1416,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417748.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446210.2",
"protein_id": "XP_024301978.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 467,
"cds_start": 31,
"cds_end": null,
"cds_length": 1404,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446210.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417749.1",
"protein_id": "XP_047273705.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 455,
"cds_start": 31,
"cds_end": null,
"cds_length": 1368,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417749.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446212.2",
"protein_id": "XP_024301980.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 412,
"cds_start": 31,
"cds_end": null,
"cds_length": 1239,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446212.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417750.1",
"protein_id": "XP_047273706.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 395,
"cds_start": 31,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417750.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417751.1",
"protein_id": "XP_047273707.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 365,
"cds_start": 31,
"cds_end": null,
"cds_length": 1098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417751.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446213.2",
"protein_id": "XP_024301981.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 338,
"cds_start": 31,
"cds_end": null,
"cds_length": 1017,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446213.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417752.1",
"protein_id": "XP_047273708.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 324,
"cds_start": 31,
"cds_end": null,
"cds_length": 975,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417752.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446214.2",
"protein_id": "XP_024301982.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 323,
"cds_start": 31,
"cds_end": null,
"cds_length": 972,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446214.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417753.1",
"protein_id": "XP_047273709.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 322,
"cds_start": 31,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417753.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417754.1",
"protein_id": "XP_047273710.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 321,
"cds_start": 31,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417754.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446215.2",
"protein_id": "XP_024301983.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 320,
"cds_start": 31,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446215.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446216.2",
"protein_id": "XP_024301984.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 320,
"cds_start": 31,
"cds_end": null,
"cds_length": 963,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446216.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_047417755.1",
"protein_id": "XP_047273711.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 306,
"cds_start": 31,
"cds_end": null,
"cds_length": 921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047417755.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZDHHC11",
"gene_hgnc_id": 19158,
"hgvs_c": "c.31G>C",
"hgvs_p": "p.Val11Leu",
"transcript": "XM_024446217.2",
"protein_id": "XP_024301985.1",
"transcript_support_level": null,
"aa_start": 11,
"aa_end": null,
"aa_length": 269,
"cds_start": 31,
"cds_end": null,
"cds_length": 810,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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}
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}