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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 5-88887834-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=88887834&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "5",
      "pos": 88887834,
      "ref": "A",
      "alt": "G",
      "effect": "intron_variant",
      "transcript": "NM_001193347.1",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-239-236T>C",
          "hgvs_p": null,
          "transcript": "ENST00000340208.9",
          "protein_id": "ENSP00000340874.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6192,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-239-236T>C",
          "hgvs_p": null,
          "transcript": "ENST00000424173.6",
          "protein_id": "ENSP00000389610.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 463,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1392,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6336,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-239-236T>C",
          "hgvs_p": null,
          "transcript": "NM_001193347.1",
          "protein_id": "NP_001180276.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 483,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1452,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6244,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-236-236T>C",
          "hgvs_p": null,
          "transcript": "NM_001364329.2",
          "protein_id": "NP_001351258.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 473,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1422,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7470,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-239-236T>C",
          "hgvs_p": null,
          "transcript": "NM_001364330.2",
          "protein_id": "NP_001351259.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 473,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1422,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7473,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-236-236T>C",
          "hgvs_p": null,
          "transcript": "ENST00000629612.2",
          "protein_id": "ENSP00000486554.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1398,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2851,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-239-236T>C",
          "hgvs_p": null,
          "transcript": "NM_001131005.2",
          "protein_id": "NP_001124477.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 463,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1392,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6184,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-236-236T>C",
          "hgvs_p": null,
          "transcript": "ENST00000625674.2",
          "protein_id": "ENSP00000487430.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 463,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1392,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4343,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-236-236T>C",
          "hgvs_p": null,
          "transcript": "NM_001364334.2",
          "protein_id": "NP_001351263.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 441,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1326,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6250,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "c.-236-236T>C",
          "hgvs_p": null,
          "transcript": "ENST00000627659.2",
          "protein_id": "ENSP00000486490.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 431,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1296,
          "cdna_start": null,
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          "cdna_length": 2393,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "n.138-236T>C",
          "hgvs_p": null,
          "transcript": "ENST00000503955.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 344,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C-AS1",
          "gene_hgnc_id": 48908,
          "hgvs_c": "n.158+4349A>G",
          "hgvs_p": null,
          "transcript": "ENST00000511100.5",
          "protein_id": null,
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          "cds_start": -4,
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        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
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          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "MEF2C-AS1",
          "gene_hgnc_id": 48908,
          "hgvs_c": "n.69+4349A>G",
          "hgvs_p": null,
          "transcript": "ENST00000512585.5",
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        {
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          ],
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          "gene_symbol": "MEF2C-AS1",
          "gene_hgnc_id": 48908,
          "hgvs_c": "n.87+4349A>G",
          "hgvs_p": null,
          "transcript": "ENST00000514794.6",
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          "cdna_length": 2350,
          "mane_select": null,
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        },
        {
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          "canonical": false,
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          "strand": false,
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          "intron_rank": 1,
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          "hgvs_c": "n.275-236T>C",
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          "gene_symbol": "MEF2C",
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          "hgvs_c": "n.67-236T>C",
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          "transcript": "ENST00000636349.1",
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        {
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          "intron_rank": 1,
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          "gene_symbol": "MEF2C",
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          "hgvs_c": "n.87-236T>C",
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          "transcript": "ENST00000637167.1",
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        {
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          "canonical": false,
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          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 2,
          "intron_rank": 1,
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          "gene_symbol": "MEF2C",
          "gene_hgnc_id": 6996,
          "hgvs_c": "n.45-236T>C",
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          "gene_symbol": "MEF2C-AS1",
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          "hgvs_c": "n.163+4349A>G",
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        {
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          "exon_count": 4,
          "intron_rank": 1,
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          "gene_symbol": "MEF2C-AS1",
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          "hgvs_c": "n.138+4349A>G",
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      "clinvar_classification": "Benign",
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      "clinvar_submissions_summary": "B:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Benign",
      "custom_annotations": null
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  "message": null
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