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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-101654362-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=101654362&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 101654362,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000369134.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "NM_021956.5",
"protein_id": "NP_068775.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 908,
"cds_start": -4,
"cds_end": null,
"cds_length": 2727,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4722,
"mane_select": "ENST00000369134.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000369134.9",
"protein_id": "ENSP00000358130.6",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 908,
"cds_start": -4,
"cds_end": null,
"cds_length": 2727,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4722,
"mane_select": "NM_021956.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000421544.6",
"protein_id": "ENSP00000397026.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 908,
"cds_start": -4,
"cds_end": null,
"cds_length": 2727,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4802,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000369138.5",
"protein_id": "ENSP00000358134.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 892,
"cds_start": -4,
"cds_end": null,
"cds_length": 2679,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000413795.5",
"protein_id": "ENSP00000405596.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 869,
"cds_start": -4,
"cds_end": null,
"cds_length": 2610,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4876,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000358361.7",
"protein_id": "ENSP00000351128.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 353,
"cds_start": -4,
"cds_end": null,
"cds_length": 1062,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1981,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000681975.1",
"protein_id": "ENSP00000508014.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 908,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4534,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000682090.1",
"protein_id": "ENSP00000508130.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 908,
"cds_start": -4,
"cds_end": null,
"cds_length": 2727,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4951,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000683215.1",
"protein_id": "ENSP00000507424.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 908,
"cds_start": -4,
"cds_end": null,
"cds_length": 2727,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4655,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "NM_001166247.1",
"protein_id": "NP_001159719.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 892,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 4,
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"gene_symbol": "GRIK2",
"gene_hgnc_id": 4580,
"hgvs_c": "c.542-22261A>C",
"hgvs_p": null,
"transcript": "ENST00000684068.1",
"protein_id": "ENSP00000508175.1",
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},
{
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],
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"gene_symbol": "GRIK2",
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"hgvs_c": "c.542-22261A>C",
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"transcript": "NM_175768.3",
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},
{
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],
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"gene_symbol": "GRIK2",
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"hgvs_c": "c.542-22261A>C",
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"transcript": "ENST00000683903.1",
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},
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],
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"gene_symbol": "GRIK2",
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"hgvs_c": "n.*533-22261A>C",
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},
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],
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},
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],
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"hgvs_c": "n.542-22261A>C",
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},
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],
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"gene_symbol": "GRIK2",
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"hgvs_c": "n.542-22261A>C",
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"transcript": "ENST00000682222.1",
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],
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],
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],
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},
{
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],
"exon_rank": null,
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"gene_symbol": "GRIK2",
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}