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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 6-107154674-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=107154674&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "6",
      "pos": 107154674,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_020381.4",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1145C>T",
          "hgvs_p": "p.Ser382Leu",
          "transcript": "NM_020381.4",
          "protein_id": "NP_065114.3",
          "transcript_support_level": null,
          "aa_start": 382,
          "aa_end": null,
          "aa_length": 399,
          "cds_start": 1145,
          "cds_end": null,
          "cds_length": 1200,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000369037.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_020381.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1145C>T",
          "hgvs_p": "p.Ser382Leu",
          "transcript": "ENST00000369037.9",
          "protein_id": "ENSP00000358033.4",
          "transcript_support_level": 1,
          "aa_start": 382,
          "aa_end": null,
          "aa_length": 399,
          "cds_start": 1145,
          "cds_end": null,
          "cds_length": 1200,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_020381.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000369037.9"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1343C>T",
          "hgvs_p": "p.Ser448Leu",
          "transcript": "ENST00000900080.1",
          "protein_id": "ENSP00000570139.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": 1343,
          "cds_end": null,
          "cds_length": 1398,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900080.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1208C>T",
          "hgvs_p": "p.Ser403Leu",
          "transcript": "ENST00000962908.1",
          "protein_id": "ENSP00000632967.1",
          "transcript_support_level": null,
          "aa_start": 403,
          "aa_end": null,
          "aa_length": 420,
          "cds_start": 1208,
          "cds_end": null,
          "cds_length": 1263,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962908.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1073C>T",
          "hgvs_p": "p.Ser358Leu",
          "transcript": "ENST00000900085.1",
          "protein_id": "ENSP00000570144.1",
          "transcript_support_level": null,
          "aa_start": 358,
          "aa_end": null,
          "aa_length": 375,
          "cds_start": 1073,
          "cds_end": null,
          "cds_length": 1128,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900085.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1013C>T",
          "hgvs_p": "p.Ser338Leu",
          "transcript": "ENST00000900079.1",
          "protein_id": "ENSP00000570138.1",
          "transcript_support_level": null,
          "aa_start": 338,
          "aa_end": null,
          "aa_length": 355,
          "cds_start": 1013,
          "cds_end": null,
          "cds_length": 1068,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900079.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1010C>T",
          "hgvs_p": "p.Ser337Leu",
          "transcript": "ENST00000900083.1",
          "protein_id": "ENSP00000570142.1",
          "transcript_support_level": null,
          "aa_start": 337,
          "aa_end": null,
          "aa_length": 354,
          "cds_start": 1010,
          "cds_end": null,
          "cds_length": 1065,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900083.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.971C>T",
          "hgvs_p": "p.Ser324Leu",
          "transcript": "ENST00000900082.1",
          "protein_id": "ENSP00000570141.1",
          "transcript_support_level": null,
          "aa_start": 324,
          "aa_end": null,
          "aa_length": 341,
          "cds_start": 971,
          "cds_end": null,
          "cds_length": 1026,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900082.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.878C>T",
          "hgvs_p": "p.Ser293Leu",
          "transcript": "ENST00000934234.1",
          "protein_id": "ENSP00000604293.1",
          "transcript_support_level": null,
          "aa_start": 293,
          "aa_end": null,
          "aa_length": 310,
          "cds_start": 878,
          "cds_end": null,
          "cds_length": 933,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934234.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.839C>T",
          "hgvs_p": "p.Ser280Leu",
          "transcript": "ENST00000900081.1",
          "protein_id": "ENSP00000570140.1",
          "transcript_support_level": null,
          "aa_start": 280,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 839,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900081.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.836C>T",
          "hgvs_p": "p.Ser279Leu",
          "transcript": "ENST00000900084.1",
          "protein_id": "ENSP00000570143.1",
          "transcript_support_level": null,
          "aa_start": 279,
          "aa_end": null,
          "aa_length": 296,
          "cds_start": 836,
          "cds_end": null,
          "cds_length": 891,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900084.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.704C>T",
          "hgvs_p": "p.Ser235Leu",
          "transcript": "ENST00000900086.1",
          "protein_id": "ENSP00000570145.1",
          "transcript_support_level": null,
          "aa_start": 235,
          "aa_end": null,
          "aa_length": 252,
          "cds_start": 704,
          "cds_end": null,
          "cds_length": 759,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000900086.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1343C>T",
          "hgvs_p": "p.Ser448Leu",
          "transcript": "XM_011535956.4",
          "protein_id": "XP_011534258.1",
          "transcript_support_level": null,
          "aa_start": 448,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": 1343,
          "cds_end": null,
          "cds_length": 1398,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011535956.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1211C>T",
          "hgvs_p": "p.Ser404Leu",
          "transcript": "XM_011535957.4",
          "protein_id": "XP_011534259.1",
          "transcript_support_level": null,
          "aa_start": 404,
          "aa_end": null,
          "aa_length": 421,
          "cds_start": 1211,
          "cds_end": null,
          "cds_length": 1266,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011535957.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1208C>T",
          "hgvs_p": "p.Ser403Leu",
          "transcript": "XM_011535958.4",
          "protein_id": "XP_011534260.1",
          "transcript_support_level": null,
          "aa_start": 403,
          "aa_end": null,
          "aa_length": 420,
          "cds_start": 1208,
          "cds_end": null,
          "cds_length": 1263,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011535958.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1037C>T",
          "hgvs_p": "p.Ser346Leu",
          "transcript": "XM_047419096.1",
          "protein_id": "XP_047275052.1",
          "transcript_support_level": null,
          "aa_start": 346,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 1037,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047419096.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1013C>T",
          "hgvs_p": "p.Ser338Leu",
          "transcript": "XM_011535959.4",
          "protein_id": "XP_011534261.1",
          "transcript_support_level": null,
          "aa_start": 338,
          "aa_end": null,
          "aa_length": 355,
          "cds_start": 1013,
          "cds_end": null,
          "cds_length": 1068,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011535959.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.1010C>T",
          "hgvs_p": "p.Ser337Leu",
          "transcript": "XM_047419097.1",
          "protein_id": "XP_047275053.1",
          "transcript_support_level": null,
          "aa_start": 337,
          "aa_end": null,
          "aa_length": 354,
          "cds_start": 1010,
          "cds_end": null,
          "cds_length": 1065,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047419097.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.935C>T",
          "hgvs_p": "p.Ser312Leu",
          "transcript": "XM_011535960.4",
          "protein_id": "XP_011534262.1",
          "transcript_support_level": null,
          "aa_start": 312,
          "aa_end": null,
          "aa_length": 329,
          "cds_start": 935,
          "cds_end": null,
          "cds_length": 990,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011535960.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.887C>T",
          "hgvs_p": "p.Ser296Leu",
          "transcript": "XM_047419098.1",
          "protein_id": "XP_047275054.1",
          "transcript_support_level": null,
          "aa_start": 296,
          "aa_end": null,
          "aa_length": 313,
          "cds_start": 887,
          "cds_end": null,
          "cds_length": 942,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047419098.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
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          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.878C>T",
          "hgvs_p": "p.Ser293Leu",
          "transcript": "XM_047419099.1",
          "protein_id": "XP_047275055.1",
          "transcript_support_level": null,
          "aa_start": 293,
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          "aa_length": 310,
          "cds_start": 878,
          "cds_end": null,
          "cds_length": 933,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047419099.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.839C>T",
          "hgvs_p": "p.Ser280Leu",
          "transcript": "XM_011535961.4",
          "protein_id": "XP_011534263.1",
          "transcript_support_level": null,
          "aa_start": 280,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 839,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011535961.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.803C>T",
          "hgvs_p": "p.Ser268Leu",
          "transcript": "XM_047419100.1",
          "protein_id": "XP_047275056.1",
          "transcript_support_level": null,
          "aa_start": 268,
          "aa_end": null,
          "aa_length": 285,
          "cds_start": 803,
          "cds_end": null,
          "cds_length": 858,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047419100.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "PDSS2",
          "gene_hgnc_id": 23041,
          "hgvs_c": "c.704C>T",
          "hgvs_p": "p.Ser235Leu",
          "transcript": "XM_047419101.1",
          "protein_id": "XP_047275057.1",
          "transcript_support_level": null,
          "aa_start": 235,
          "aa_end": null,
          "aa_length": 252,
          "cds_start": 704,
          "cds_end": null,
          "cds_length": 759,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047419101.1"
        }
      ],
      "gene_symbol": "PDSS2",
      "gene_hgnc_id": 23041,
      "dbsnp": "rs118203956",
      "frequency_reference_population": 0.000021685415,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 35,
      "gnomad_exomes_af": 0.0000218907,
      "gnomad_genomes_af": 0.0000197138,
      "gnomad_exomes_ac": 32,
      "gnomad_genomes_ac": 3,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.8626240491867065,
      "computational_prediction_selected": "Pathogenic",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.737,
      "revel_prediction": "Pathogenic",
      "alphamissense_score": 0.5801,
      "alphamissense_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.3,
      "bayesdelnoaf_prediction": "Pathogenic",
      "phylop100way_score": 8.174,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 5,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3_Moderate,PP5",
      "acmg_by_gene": [
        {
          "score": 5,
          "benign_score": 0,
          "pathogenic_score": 5,
          "criteria": [
            "PM2",
            "PP3_Moderate",
            "PP5"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_020381.4",
          "gene_symbol": "PDSS2",
          "hgnc_id": 23041,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1145C>T",
          "hgvs_p": "p.Ser382Leu"
        }
      ],
      "clinvar_disease": " 3, primary,Coenzyme Q10 deficiency,Nephrotic syndrome,not provided,not specified",
      "clinvar_classification": "Conflicting classifications of pathogenicity",
      "clinvar_review_status": "criteria provided, conflicting classifications",
      "clinvar_submissions_summary": "LP:1 US:2 O:1",
      "phenotype_combined": "Coenzyme Q10 deficiency, primary, 3|Nephrotic syndrome|not specified|not provided",
      "pathogenicity_classification_combined": "Conflicting classifications of pathogenicity",
      "custom_annotations": null
    }
  ],
  "message": null
}