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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 6-110960430-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=110960430&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "6",
      "pos": 110960430,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_138408.4",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "NM_138408.4",
          "protein_id": "NP_612417.1",
          "transcript_support_level": null,
          "aa_start": 52,
          "aa_end": null,
          "aa_length": 213,
          "cds_start": 155,
          "cds_end": null,
          "cds_length": 642,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000329970.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_138408.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000329970.8",
          "protein_id": "ENSP00000357863.4",
          "transcript_support_level": 1,
          "aa_start": 52,
          "aa_end": null,
          "aa_length": 213,
          "cds_start": 155,
          "cds_end": null,
          "cds_length": 642,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_138408.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000329970.8"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000935770.1",
          "protein_id": "ENSP00000605829.1",
          "transcript_support_level": null,
          "aa_start": 52,
          "aa_end": null,
          "aa_length": 259,
          "cds_start": 155,
          "cds_end": null,
          "cds_length": 780,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935770.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.212G>C",
          "hgvs_p": "p.Arg71Thr",
          "transcript": "ENST00000935771.1",
          "protein_id": "ENSP00000605830.1",
          "transcript_support_level": null,
          "aa_start": 71,
          "aa_end": null,
          "aa_length": 232,
          "cds_start": 212,
          "cds_end": null,
          "cds_length": 699,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935771.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.182G>C",
          "hgvs_p": "p.Arg61Thr",
          "transcript": "ENST00000935762.1",
          "protein_id": "ENSP00000605821.1",
          "transcript_support_level": null,
          "aa_start": 61,
          "aa_end": null,
          "aa_length": 222,
          "cds_start": 182,
          "cds_end": null,
          "cds_length": 669,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935762.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.158G>C",
          "hgvs_p": "p.Arg53Thr",
          "transcript": "ENST00000883260.1",
          "protein_id": "ENSP00000553319.1",
          "transcript_support_level": null,
          "aa_start": 53,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 158,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000883260.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000935766.1",
          "protein_id": "ENSP00000605825.1",
          "transcript_support_level": null,
          "aa_start": 52,
          "aa_end": null,
          "aa_length": 213,
          "cds_start": 155,
          "cds_end": null,
          "cds_length": 642,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935766.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.152G>C",
          "hgvs_p": "p.Arg51Thr",
          "transcript": "ENST00000935759.1",
          "protein_id": "ENSP00000605818.1",
          "transcript_support_level": null,
          "aa_start": 51,
          "aa_end": null,
          "aa_length": 212,
          "cds_start": 152,
          "cds_end": null,
          "cds_length": 639,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935759.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.152G>C",
          "hgvs_p": "p.Arg51Thr",
          "transcript": "ENST00000935764.1",
          "protein_id": "ENSP00000605823.1",
          "transcript_support_level": null,
          "aa_start": 51,
          "aa_end": null,
          "aa_length": 212,
          "cds_start": 152,
          "cds_end": null,
          "cds_length": 639,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935764.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.149G>C",
          "hgvs_p": "p.Arg50Thr",
          "transcript": "ENST00000883264.1",
          "protein_id": "ENSP00000553323.1",
          "transcript_support_level": null,
          "aa_start": 50,
          "aa_end": null,
          "aa_length": 211,
          "cds_start": 149,
          "cds_end": null,
          "cds_length": 636,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000883264.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.149G>C",
          "hgvs_p": "p.Arg50Thr",
          "transcript": "ENST00000883265.1",
          "protein_id": "ENSP00000553324.1",
          "transcript_support_level": null,
          "aa_start": 50,
          "aa_end": null,
          "aa_length": 211,
          "cds_start": 149,
          "cds_end": null,
          "cds_length": 636,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000883265.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.158G>C",
          "hgvs_p": "p.Arg53Thr",
          "transcript": "ENST00000935763.1",
          "protein_id": "ENSP00000605822.1",
          "transcript_support_level": null,
          "aa_start": 53,
          "aa_end": null,
          "aa_length": 211,
          "cds_start": 158,
          "cds_end": null,
          "cds_length": 636,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.158G>C",
          "hgvs_p": "p.Arg53Thr",
          "transcript": "ENST00000935765.1",
          "protein_id": "ENSP00000605824.1",
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          "aa_end": null,
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          "cds_start": 158,
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          "cds_length": 636,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000935765.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000883262.1",
          "protein_id": "ENSP00000553321.1",
          "transcript_support_level": null,
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          "aa_end": null,
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          "cds_start": 155,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000935760.1",
          "protein_id": "ENSP00000605819.1",
          "transcript_support_level": null,
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          "aa_end": null,
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          "cds_start": 155,
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          "cds_length": 633,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000935760.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.158G>C",
          "hgvs_p": "p.Arg53Thr",
          "transcript": "ENST00000935761.1",
          "protein_id": "ENSP00000605820.1",
          "transcript_support_level": null,
          "aa_start": 53,
          "aa_end": null,
          "aa_length": 199,
          "cds_start": 158,
          "cds_end": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000935761.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000883263.1",
          "protein_id": "ENSP00000553322.1",
          "transcript_support_level": null,
          "aa_start": 52,
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          "biotype": "protein_coding",
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        {
          "aa_ref": "R",
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          ],
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          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.74G>C",
          "hgvs_p": "p.Arg25Thr",
          "transcript": "ENST00000883261.1",
          "protein_id": "ENSP00000553320.1",
          "transcript_support_level": null,
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          "aa_end": null,
          "aa_length": 186,
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          "biotype": "protein_coding",
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        },
        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
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          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000935767.1",
          "protein_id": "ENSP00000605826.1",
          "transcript_support_level": null,
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          "cds_start": 155,
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          "cds_length": 558,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935767.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.158G>C",
          "hgvs_p": "p.Arg53Thr",
          "transcript": "ENST00000935768.1",
          "protein_id": "ENSP00000605827.1",
          "transcript_support_level": null,
          "aa_start": 53,
          "aa_end": null,
          "aa_length": 176,
          "cds_start": 158,
          "cds_end": null,
          "cds_length": 531,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935768.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr",
          "transcript": "ENST00000935769.1",
          "protein_id": "ENSP00000605828.1",
          "transcript_support_level": null,
          "aa_start": 52,
          "aa_end": null,
          "aa_length": 175,
          "cds_start": 155,
          "cds_end": null,
          "cds_length": 528,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935769.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GTF3C6",
          "gene_hgnc_id": 20872,
          "hgvs_c": "n.213G>C",
          "hgvs_p": null,
          "transcript": "ENST00000480191.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000480191.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000298854",
          "gene_hgnc_id": null,
          "hgvs_c": "n.225C>G",
          "hgvs_p": null,
          "transcript": "ENST00000758433.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000758433.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000298854",
          "gene_hgnc_id": null,
          "hgvs_c": "n.379C>G",
          "hgvs_p": null,
          "transcript": "ENST00000758434.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000758434.1"
        }
      ],
      "gene_symbol": "GTF3C6",
      "gene_hgnc_id": 20872,
      "dbsnp": null,
      "frequency_reference_population": 6.842426e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 6.84243e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.4189468026161194,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.247,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.3812,
      "alphamissense_prediction": "Uncertain_significance",
      "bayesdelnoaf_score": -0.05,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 1.213,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_by_gene": [
        {
          "score": 1,
          "benign_score": 1,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_138408.4",
          "gene_symbol": "GTF3C6",
          "hgnc_id": 20872,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.155G>C",
          "hgvs_p": "p.Arg52Thr"
        },
        {
          "score": 1,
          "benign_score": 1,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000758433.1",
          "gene_symbol": "ENSG00000298854",
          "hgnc_id": null,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.225C>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}