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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-111559489-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=111559489&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 111559489,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_147200.3",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "NM_147686.4",
"protein_id": "NP_679211.2",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000368761.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_147686.4"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000368761.11",
"protein_id": "ENSP00000357750.5",
"transcript_support_level": 1,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_147686.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368761.11"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1641C>A",
"hgvs_p": "p.Asn547Lys",
"transcript": "ENST00000340026.10",
"protein_id": "ENSP00000345984.6",
"transcript_support_level": 1,
"aa_start": 547,
"aa_end": null,
"aa_length": 574,
"cds_start": 1641,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000340026.10"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1641C>A",
"hgvs_p": "p.Asn547Lys",
"transcript": "NM_147200.3",
"protein_id": "NP_671733.2",
"transcript_support_level": null,
"aa_start": 547,
"aa_end": null,
"aa_length": 574,
"cds_start": 1641,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_147200.3"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000651547.2",
"protein_id": "ENSP00000514681.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000651547.2"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000907309.1",
"protein_id": "ENSP00000577368.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907309.1"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000907310.1",
"protein_id": "ENSP00000577369.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907310.1"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000912363.1",
"protein_id": "ENSP00000582422.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912363.1"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000945262.1",
"protein_id": "ENSP00000615321.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945262.1"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1614C>A",
"hgvs_p": "p.Asn538Lys",
"transcript": "ENST00000945263.1",
"protein_id": "ENSP00000615322.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 565,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945263.1"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1611C>A",
"hgvs_p": "p.Asn537Lys",
"transcript": "NM_001164281.3",
"protein_id": "NP_001157753.1",
"transcript_support_level": null,
"aa_start": 537,
"aa_end": null,
"aa_length": 564,
"cds_start": 1611,
"cds_end": null,
"cds_length": 1695,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164281.3"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.1611C>A",
"hgvs_p": "p.Asn537Lys",
"transcript": "ENST00000359831.8",
"protein_id": "ENSP00000352889.4",
"transcript_support_level": 2,
"aa_start": 537,
"aa_end": null,
"aa_length": 564,
"cds_start": 1611,
"cds_end": null,
"cds_length": 1695,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000359831.8"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.246C>A",
"hgvs_p": "p.Asn82Lys",
"transcript": "NM_001164283.3",
"protein_id": "NP_001157755.1",
"transcript_support_level": null,
"aa_start": 82,
"aa_end": null,
"aa_length": 109,
"cds_start": 246,
"cds_end": null,
"cds_length": 330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164283.3"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.246C>A",
"hgvs_p": "p.Asn82Lys",
"transcript": "ENST00000368730.5",
"protein_id": "ENSP00000498323.1",
"transcript_support_level": 3,
"aa_start": 82,
"aa_end": null,
"aa_length": 109,
"cds_start": 246,
"cds_end": null,
"cds_length": 330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368730.5"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.246C>A",
"hgvs_p": "p.Asn82Lys",
"transcript": "ENST00000368734.5",
"protein_id": "ENSP00000498345.1",
"transcript_support_level": 3,
"aa_start": 82,
"aa_end": null,
"aa_length": 109,
"cds_start": 246,
"cds_end": null,
"cds_length": 330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368734.5"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.246C>A",
"hgvs_p": "p.Asn82Lys",
"transcript": "ENST00000368735.1",
"protein_id": "ENSP00000357724.1",
"transcript_support_level": 2,
"aa_start": 82,
"aa_end": null,
"aa_length": 109,
"cds_start": 246,
"cds_end": null,
"cds_length": 330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368735.1"
},
{
"aa_ref": "N",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "c.120C>A",
"hgvs_p": "p.Asn40Lys",
"transcript": "ENST00000492671.1",
"protein_id": "ENSP00000498694.1",
"transcript_support_level": 3,
"aa_start": 40,
"aa_end": null,
"aa_length": 67,
"cds_start": 120,
"cds_end": null,
"cds_length": 204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000492671.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "n.879C>A",
"hgvs_p": null,
"transcript": "ENST00000368731.6",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000368731.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "n.848C>A",
"hgvs_p": null,
"transcript": "ENST00000699907.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000699907.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "n.507C>A",
"hgvs_p": null,
"transcript": "ENST00000699908.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000699908.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2",
"gene_hgnc_id": 1343,
"hgvs_c": "n.1142C>A",
"hgvs_p": null,
"transcript": "ENST00000699909.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000699909.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TRAF3IP2-AS1",
"gene_hgnc_id": 40005,
"hgvs_c": "n.251-15132G>T",
"hgvs_p": null,
"transcript": "ENST00000438298.8",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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