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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-111674591-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=111674591&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 111674591,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_002037.5",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "NM_002037.5",
"protein_id": "NP_002028.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000354650.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002037.5"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000354650.7",
"protein_id": "ENSP00000346671.3",
"transcript_support_level": 1,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002037.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354650.7"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1148C>A",
"hgvs_p": "p.Ala383Asp",
"transcript": "ENST00000229471.8",
"protein_id": "ENSP00000229471.4",
"transcript_support_level": 1,
"aa_start": 383,
"aa_end": null,
"aa_length": 482,
"cds_start": 1148,
"cds_end": null,
"cds_length": 1449,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000229471.8"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1469C>A",
"hgvs_p": "p.Ala490Asp",
"transcript": "ENST00000905552.1",
"protein_id": "ENSP00000575611.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 589,
"cds_start": 1469,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905552.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1469C>A",
"hgvs_p": "p.Ala490Asp",
"transcript": "ENST00000912320.1",
"protein_id": "ENSP00000582379.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 589,
"cds_start": 1469,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912320.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1469C>A",
"hgvs_p": "p.Ala490Asp",
"transcript": "ENST00000912326.1",
"protein_id": "ENSP00000582385.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 589,
"cds_start": 1469,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912326.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1469C>A",
"hgvs_p": "p.Ala490Asp",
"transcript": "ENST00000912327.1",
"protein_id": "ENSP00000582386.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 589,
"cds_start": 1469,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912327.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1397C>A",
"hgvs_p": "p.Ala466Asp",
"transcript": "ENST00000966567.1",
"protein_id": "ENSP00000636626.1",
"transcript_support_level": null,
"aa_start": 466,
"aa_end": null,
"aa_length": 565,
"cds_start": 1397,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966567.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1382C>A",
"hgvs_p": "p.Ala461Asp",
"transcript": "ENST00000912325.1",
"protein_id": "ENSP00000582384.1",
"transcript_support_level": null,
"aa_start": 461,
"aa_end": null,
"aa_length": 560,
"cds_start": 1382,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912325.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1373C>A",
"hgvs_p": "p.Ala458Asp",
"transcript": "ENST00000912324.1",
"protein_id": "ENSP00000582383.1",
"transcript_support_level": null,
"aa_start": 458,
"aa_end": null,
"aa_length": 557,
"cds_start": 1373,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912324.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1343C>A",
"hgvs_p": "p.Ala448Asp",
"transcript": "ENST00000912314.1",
"protein_id": "ENSP00000582373.1",
"transcript_support_level": null,
"aa_start": 448,
"aa_end": null,
"aa_length": 547,
"cds_start": 1343,
"cds_end": null,
"cds_length": 1644,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912314.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "NM_001370529.1",
"protein_id": "NP_001357458.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370529.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000368667.6",
"protein_id": "ENSP00000357656.2",
"transcript_support_level": 5,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368667.6"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905530.1",
"protein_id": "ENSP00000575589.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905530.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905533.1",
"protein_id": "ENSP00000575592.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905533.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905535.1",
"protein_id": "ENSP00000575594.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905535.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905540.1",
"protein_id": "ENSP00000575599.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905540.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905541.1",
"protein_id": "ENSP00000575600.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905541.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905543.1",
"protein_id": "ENSP00000575602.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905543.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905548.1",
"protein_id": "ENSP00000575607.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905548.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905549.1",
"protein_id": "ENSP00000575608.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905549.1"
},
{
"aa_ref": "A",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FYN",
"gene_hgnc_id": 4037,
"hgvs_c": "c.1313C>A",
"hgvs_p": "p.Ala438Asp",
"transcript": "ENST00000905550.1",
"protein_id": "ENSP00000575609.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 537,
"cds_start": 1313,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000905550.1"
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}
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"message": null
}