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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-154091101-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=154091101&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 154091101,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000330432.12",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "NM_000914.5",
"protein_id": "NP_000905.3",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 400,
"cds_start": 793,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1098,
"cdna_end": null,
"cdna_length": 15143,
"mane_select": "ENST00000330432.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000330432.12",
"protein_id": "ENSP00000328264.7",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 400,
"cds_start": 793,
"cds_end": null,
"cds_length": 1203,
"cdna_start": 1098,
"cdna_end": null,
"cdna_length": 15143,
"mane_select": "NM_000914.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.1072C>T",
"hgvs_p": "p.Arg358Cys",
"transcript": "ENST00000434900.6",
"protein_id": "ENSP00000394624.2",
"transcript_support_level": 1,
"aa_start": 358,
"aa_end": null,
"aa_length": 493,
"cds_start": 1072,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 1590,
"cdna_end": null,
"cdna_length": 2033,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.979C>T",
"hgvs_p": "p.Arg327Cys",
"transcript": "ENST00000360422.8",
"protein_id": "ENSP00000353598.5",
"transcript_support_level": 1,
"aa_start": 327,
"aa_end": null,
"aa_length": 476,
"cds_start": 979,
"cds_end": null,
"cds_length": 1431,
"cdna_start": 1236,
"cdna_end": null,
"cdna_length": 1737,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000229768.9",
"protein_id": "ENSP00000229768.5",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 446,
"cds_start": 793,
"cds_end": null,
"cds_length": 1341,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 1465,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000419506.6",
"protein_id": "ENSP00000403549.2",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 420,
"cds_start": 793,
"cds_end": null,
"cds_length": 1263,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 1402,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000337049.8",
"protein_id": "ENSP00000338381.4",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 418,
"cds_start": 793,
"cds_end": null,
"cds_length": 1257,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 1389,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000452687.6",
"protein_id": "ENSP00000410497.2",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 406,
"cds_start": 793,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 882,
"cdna_end": null,
"cdna_length": 1352,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000414028.6",
"protein_id": "ENSP00000399359.2",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 403,
"cds_start": 793,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 2485,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000435918.6",
"protein_id": "ENSP00000413752.2",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 397,
"cds_start": 793,
"cds_end": null,
"cds_length": 1194,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 2217,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000428397.6",
"protein_id": "ENSP00000411903.2",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 392,
"cds_start": 793,
"cds_end": null,
"cds_length": 1179,
"cdna_start": 989,
"cdna_end": null,
"cdna_length": 1481,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "ENST00000524163.5",
"protein_id": "ENSP00000430097.1",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 389,
"cds_start": 793,
"cds_end": null,
"cds_length": 1170,
"cdna_start": 843,
"cdna_end": null,
"cdna_length": 1251,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.550C>T",
"hgvs_p": "p.Arg184Cys",
"transcript": "ENST00000518759.5",
"protein_id": "ENSP00000430260.1",
"transcript_support_level": 1,
"aa_start": 184,
"aa_end": null,
"aa_length": 319,
"cds_start": 550,
"cds_end": null,
"cds_length": 960,
"cdna_start": 562,
"cdna_end": null,
"cdna_length": 1060,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Arg165Cys",
"transcript": "ENST00000520708.5",
"protein_id": "ENSP00000430876.1",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 300,
"cds_start": 493,
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"cdna_start": 1021,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Arg165Cys",
"transcript": "ENST00000522236.1",
"protein_id": "ENSP00000429373.1",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 300,
"cds_start": 493,
"cds_end": null,
"cds_length": 903,
"cdna_start": 1801,
"cdna_end": null,
"cdna_length": 2459,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.493C>T",
"hgvs_p": "p.Arg165Cys",
"transcript": "ENST00000522555.5",
"protein_id": "ENSP00000429719.1",
"transcript_support_level": 1,
"aa_start": 165,
"aa_end": null,
"aa_length": 300,
"cds_start": 493,
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"cdna_start": 1782,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "n.725C>T",
"hgvs_p": null,
"transcript": "ENST00000519613.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1127,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "n.567C>T",
"hgvs_p": null,
"transcript": "ENST00000522382.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1404,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "n.793C>T",
"hgvs_p": null,
"transcript": "ENST00000522739.5",
"protein_id": "ENSP00000428018.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": 1468,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.1072C>T",
"hgvs_p": "p.Arg358Cys",
"transcript": "NM_001145279.4",
"protein_id": "NP_001138751.1",
"transcript_support_level": null,
"aa_start": 358,
"aa_end": null,
"aa_length": 493,
"cds_start": 1072,
"cds_end": null,
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"cdna_start": 1595,
"cdna_end": null,
"cdna_length": 15640,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.1072C>T",
"hgvs_p": "p.Arg358Cys",
"transcript": "NM_001285524.1",
"protein_id": "NP_001272453.1",
"transcript_support_level": null,
"aa_start": 358,
"aa_end": null,
"aa_length": 493,
"cds_start": 1072,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 1131,
"cdna_end": null,
"cdna_length": 15174,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "NM_001008505.2",
"protein_id": "NP_001008505.2",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 446,
"cds_start": 793,
"cds_end": null,
"cds_length": 1341,
"cdna_start": 927,
"cdna_end": null,
"cdna_length": 1549,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OPRM1",
"gene_hgnc_id": 8156,
"hgvs_c": "c.793C>T",
"hgvs_p": "p.Arg265Cys",
"transcript": "NM_001145286.3",
"protein_id": "NP_001138758.1",
"transcript_support_level": null,
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],
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{
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"verdict": "Likely_benign",
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"clinvar_disease": "",
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}