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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-158701052-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=158701052&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 158701052,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000611299.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "NM_001242394.2",
"protein_id": "NP_001229323.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2851,
"mane_select": "ENST00000611299.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "ENST00000611299.5",
"protein_id": "ENSP00000483936.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2851,
"mane_select": "NM_001242394.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "NM_001242384.2",
"protein_id": "NP_001229313.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2459,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "ENST00000360448.8",
"protein_id": "ENSP00000353631.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2497,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "NM_001009991.4",
"protein_id": "NP_001009991.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 542,
"cds_start": -4,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2239,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "NM_001242395.2",
"protein_id": "NP_001229324.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 542,
"cds_start": -4,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2647,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "ENST00000367081.7",
"protein_id": "ENSP00000356048.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 542,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2692,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.-224-6178G>A",
"hgvs_p": null,
"transcript": "NM_001318745.2",
"protein_id": "NP_001305674.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 404,
"cds_start": -4,
"cds_end": null,
"cds_length": 1215,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "XM_006715606.4",
"protein_id": "XP_006715669.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
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"cds_length": 1833,
"cdna_start": null,
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"cdna_length": 2965,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 7,
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"gene_symbol": "SYTL3",
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"hgvs_c": "c.395-6178G>A",
"hgvs_p": null,
"transcript": "XM_011536254.3",
"protein_id": "XP_011534556.1",
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 7,
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"gene_symbol": "SYTL3",
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"hgvs_c": "c.395-6178G>A",
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"transcript": "XM_047419549.1",
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},
{
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],
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},
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],
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],
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],
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},
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],
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},
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],
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"gene_symbol": "SYTL3",
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"hgvs_c": "c.-224-6178G>A",
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},
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],
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"gene_symbol": "SYTL3",
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}
],
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}