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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-158763446-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=158763446&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 158763446,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001242394.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "NM_001242394.2",
"protein_id": "NP_001229323.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 2411,
"cdna_end": null,
"cdna_length": 2851,
"mane_select": "ENST00000611299.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "ENST00000611299.5",
"protein_id": "ENSP00000483936.1",
"transcript_support_level": 5,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 2411,
"cdna_end": null,
"cdna_length": 2851,
"mane_select": "NM_001242394.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "NM_001242384.2",
"protein_id": "NP_001229313.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 2019,
"cdna_end": null,
"cdna_length": 2459,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "ENST00000360448.8",
"protein_id": "ENSP00000353631.4",
"transcript_support_level": 5,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 2059,
"cdna_end": null,
"cdna_length": 2497,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1456G>A",
"hgvs_p": "p.Val486Ile",
"transcript": "NM_001009991.4",
"protein_id": "NP_001009991.2",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 542,
"cds_start": 1456,
"cds_end": null,
"cds_length": 1629,
"cdna_start": 1799,
"cdna_end": null,
"cdna_length": 2239,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1456G>A",
"hgvs_p": "p.Val486Ile",
"transcript": "NM_001242395.2",
"protein_id": "NP_001229324.1",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 542,
"cds_start": 1456,
"cds_end": null,
"cds_length": 1629,
"cdna_start": 2207,
"cdna_end": null,
"cdna_length": 2647,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1456G>A",
"hgvs_p": "p.Val486Ile",
"transcript": "ENST00000367081.7",
"protein_id": "ENSP00000356048.4",
"transcript_support_level": 5,
"aa_start": 486,
"aa_end": null,
"aa_length": 542,
"cds_start": 1456,
"cds_end": null,
"cds_length": 1629,
"cdna_start": 2247,
"cdna_end": null,
"cdna_length": 2692,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1042G>A",
"hgvs_p": "p.Val348Ile",
"transcript": "NM_001318745.2",
"protein_id": "NP_001305674.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 404,
"cds_start": 1042,
"cds_end": null,
"cds_length": 1215,
"cdna_start": 2229,
"cdna_end": null,
"cdna_length": 2669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "XM_006715606.4",
"protein_id": "XP_006715669.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 2525,
"cdna_end": null,
"cdna_length": 2965,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "XM_011536254.3",
"protein_id": "XP_011534556.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
"cds_end": null,
"cds_length": 1833,
"cdna_start": 2293,
"cdna_end": null,
"cdna_length": 2733,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "XM_047419549.1",
"protein_id": "XP_047275505.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 610,
"cds_start": 1660,
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"cdna_start": 2251,
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"mane_select": null,
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"feature": null
},
{
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"consequences": [
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],
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"exon_count": 19,
"intron_rank": null,
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"gene_symbol": "SYTL3",
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"transcript": "XM_047419550.1",
"protein_id": "XP_047275506.1",
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"aa_start": 554,
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"aa_length": 610,
"cds_start": 1660,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 17,
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"exon_count": 18,
"intron_rank": null,
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"gene_symbol": "SYTL3",
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"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "XM_047419551.1",
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"cds_start": 1660,
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"cdna_start": 1929,
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},
{
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],
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"gene_symbol": "SYTL3",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1660G>A",
"hgvs_p": "p.Val554Ile",
"transcript": "XM_047419553.1",
"protein_id": "XP_047275509.1",
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"aa_end": null,
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"cds_start": 1660,
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},
{
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"strand": true,
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],
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"intron_rank": null,
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"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1456G>A",
"hgvs_p": "p.Val486Ile",
"transcript": "XM_047419554.1",
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},
{
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"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
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"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1456G>A",
"hgvs_p": "p.Val486Ile",
"transcript": "XM_047419555.1",
"protein_id": "XP_047275511.1",
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"aa_start": 486,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"strand": true,
"consequences": [
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],
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"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
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"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1456G>A",
"hgvs_p": "p.Val486Ile",
"transcript": "XM_047419556.1",
"protein_id": "XP_047275512.1",
"transcript_support_level": null,
"aa_start": 486,
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"cds_start": 1456,
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},
{
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],
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"gene_symbol": "SYTL3",
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"transcript": "XM_047419557.1",
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},
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"intron_rank": null,
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"gene_symbol": "SYTL3",
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"transcript": "XM_047419558.1",
"protein_id": "XP_047275514.1",
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},
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],
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"intron_rank": null,
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"gene_symbol": "SYTL3",
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"hgvs_p": "p.Val353Ile",
"transcript": "XM_011536255.3",
"protein_id": "XP_011534557.1",
"transcript_support_level": null,
"aa_start": 353,
"aa_end": null,
"aa_length": 409,
"cds_start": 1057,
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"cdna_start": 3548,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
"gene_hgnc_id": 15587,
"hgvs_c": "c.1042G>A",
"hgvs_p": "p.Val348Ile",
"transcript": "XM_005267222.5",
"protein_id": "XP_005267279.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 404,
"cds_start": 1042,
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"cdna_start": 1135,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL3",
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}