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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 6-17625876-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=17625876&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "6",
      "pos": 17625876,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_001278209.2",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3833G>A",
          "hgvs_p": "p.Gly1278Glu",
          "transcript": "NM_005124.4",
          "protein_id": "NP_005115.2",
          "transcript_support_level": null,
          "aa_start": 1278,
          "aa_end": null,
          "aa_length": 1475,
          "cds_start": 3833,
          "cds_end": null,
          "cds_length": 4428,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000262077.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_005124.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3833G>A",
          "hgvs_p": "p.Gly1278Glu",
          "transcript": "ENST00000262077.3",
          "protein_id": "ENSP00000262077.3",
          "transcript_support_level": 1,
          "aa_start": 1278,
          "aa_end": null,
          "aa_length": 1475,
          "cds_start": 3833,
          "cds_end": null,
          "cds_length": 4428,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_005124.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000262077.3"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3707G>A",
          "hgvs_p": "p.Gly1236Glu",
          "transcript": "ENST00000613258.4",
          "protein_id": "ENSP00000478627.1",
          "transcript_support_level": 1,
          "aa_start": 1236,
          "aa_end": null,
          "aa_length": 1433,
          "cds_start": 3707,
          "cds_end": null,
          "cds_length": 4302,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000613258.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3926G>A",
          "hgvs_p": "p.Gly1309Glu",
          "transcript": "NM_001278209.2",
          "protein_id": "NP_001265138.1",
          "transcript_support_level": null,
          "aa_start": 1309,
          "aa_end": null,
          "aa_length": 1506,
          "cds_start": 3926,
          "cds_end": null,
          "cds_length": 4521,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001278209.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3926G>A",
          "hgvs_p": "p.Gly1309Glu",
          "transcript": "ENST00000537253.5",
          "protein_id": "ENSP00000444029.1",
          "transcript_support_level": 2,
          "aa_start": 1309,
          "aa_end": null,
          "aa_length": 1506,
          "cds_start": 3926,
          "cds_end": null,
          "cds_length": 4521,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000537253.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3902G>A",
          "hgvs_p": "p.Gly1301Glu",
          "transcript": "ENST00000874443.1",
          "protein_id": "ENSP00000544502.1",
          "transcript_support_level": null,
          "aa_start": 1301,
          "aa_end": null,
          "aa_length": 1498,
          "cds_start": 3902,
          "cds_end": null,
          "cds_length": 4497,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000874443.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3872G>A",
          "hgvs_p": "p.Gly1291Glu",
          "transcript": "ENST00000940942.1",
          "protein_id": "ENSP00000611001.1",
          "transcript_support_level": null,
          "aa_start": 1291,
          "aa_end": null,
          "aa_length": 1488,
          "cds_start": 3872,
          "cds_end": null,
          "cds_length": 4467,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000940942.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3824G>A",
          "hgvs_p": "p.Gly1275Glu",
          "transcript": "ENST00000912068.1",
          "protein_id": "ENSP00000582127.1",
          "transcript_support_level": null,
          "aa_start": 1275,
          "aa_end": null,
          "aa_length": 1472,
          "cds_start": 3824,
          "cds_end": null,
          "cds_length": 4419,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912068.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3815G>A",
          "hgvs_p": "p.Gly1272Glu",
          "transcript": "ENST00000874441.1",
          "protein_id": "ENSP00000544500.1",
          "transcript_support_level": null,
          "aa_start": 1272,
          "aa_end": null,
          "aa_length": 1469,
          "cds_start": 3815,
          "cds_end": null,
          "cds_length": 4410,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000874441.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3809G>A",
          "hgvs_p": "p.Gly1270Glu",
          "transcript": "ENST00000874446.1",
          "protein_id": "ENSP00000544505.1",
          "transcript_support_level": null,
          "aa_start": 1270,
          "aa_end": null,
          "aa_length": 1467,
          "cds_start": 3809,
          "cds_end": null,
          "cds_length": 4404,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000874446.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3797G>A",
          "hgvs_p": "p.Gly1266Glu",
          "transcript": "ENST00000874444.1",
          "protein_id": "ENSP00000544503.1",
          "transcript_support_level": null,
          "aa_start": 1266,
          "aa_end": null,
          "aa_length": 1463,
          "cds_start": 3797,
          "cds_end": null,
          "cds_length": 4392,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000874444.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3779G>A",
          "hgvs_p": "p.Gly1260Glu",
          "transcript": "ENST00000874440.1",
          "protein_id": "ENSP00000544499.1",
          "transcript_support_level": null,
          "aa_start": 1260,
          "aa_end": null,
          "aa_length": 1457,
          "cds_start": 3779,
          "cds_end": null,
          "cds_length": 4374,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000874440.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3761G>A",
          "hgvs_p": "p.Gly1254Glu",
          "transcript": "ENST00000912066.1",
          "protein_id": "ENSP00000582125.1",
          "transcript_support_level": null,
          "aa_start": 1254,
          "aa_end": null,
          "aa_length": 1451,
          "cds_start": 3761,
          "cds_end": null,
          "cds_length": 4356,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912066.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3755G>A",
          "hgvs_p": "p.Gly1252Glu",
          "transcript": "ENST00000912064.1",
          "protein_id": "ENSP00000582123.1",
          "transcript_support_level": null,
          "aa_start": 1252,
          "aa_end": null,
          "aa_length": 1449,
          "cds_start": 3755,
          "cds_end": null,
          "cds_length": 4350,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912064.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3734G>A",
          "hgvs_p": "p.Gly1245Glu",
          "transcript": "ENST00000912065.1",
          "protein_id": "ENSP00000582124.1",
          "transcript_support_level": null,
          "aa_start": 1245,
          "aa_end": null,
          "aa_length": 1442,
          "cds_start": 3734,
          "cds_end": null,
          "cds_length": 4329,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912065.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3716G>A",
          "hgvs_p": "p.Gly1239Glu",
          "transcript": "ENST00000940941.1",
          "protein_id": "ENSP00000611000.1",
          "transcript_support_level": null,
          "aa_start": 1239,
          "aa_end": null,
          "aa_length": 1436,
          "cds_start": 3716,
          "cds_end": null,
          "cds_length": 4311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000940941.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3707G>A",
          "hgvs_p": "p.Gly1236Glu",
          "transcript": "NM_001278210.2",
          "protein_id": "NP_001265139.1",
          "transcript_support_level": null,
          "aa_start": 1236,
          "aa_end": null,
          "aa_length": 1433,
          "cds_start": 3707,
          "cds_end": null,
          "cds_length": 4302,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001278210.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3686G>A",
          "hgvs_p": "p.Gly1229Glu",
          "transcript": "ENST00000912070.1",
          "protein_id": "ENSP00000582129.1",
          "transcript_support_level": null,
          "aa_start": 1229,
          "aa_end": null,
          "aa_length": 1426,
          "cds_start": 3686,
          "cds_end": null,
          "cds_length": 4281,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912070.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3638G>A",
          "hgvs_p": "p.Gly1213Glu",
          "transcript": "ENST00000912067.1",
          "protein_id": "ENSP00000582126.1",
          "transcript_support_level": null,
          "aa_start": 1213,
          "aa_end": null,
          "aa_length": 1410,
          "cds_start": 3638,
          "cds_end": null,
          "cds_length": 4233,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912067.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP153",
          "gene_hgnc_id": 8062,
          "hgvs_c": "c.3617G>A",
          "hgvs_p": "p.Gly1206Glu",
          "transcript": "ENST00000874442.1",
          "protein_id": "ENSP00000544501.1",
          "transcript_support_level": null,
          "aa_start": 1206,
          "aa_end": null,
          "aa_length": 1403,
          "cds_start": 3617,
          "cds_end": null,
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          "feature": "ENST00000940939.1"
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      ],
      "gene_symbol": "NUP153",
      "gene_hgnc_id": 8062,
      "dbsnp": "rs981373966",
      "frequency_reference_population": 0.0000041043095,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 6,
      "gnomad_exomes_af": 0.00000410431,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 6,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.2394028902053833,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.086,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.2249,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.41,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 2.782,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -6,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate,BS2",
      "acmg_by_gene": [
        {
          "score": -6,
          "benign_score": 6,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BS2"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_001278209.2",
          "gene_symbol": "NUP153",
          "hgnc_id": 8062,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.3926G>A",
          "hgvs_p": "p.Gly1309Glu"
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      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}