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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-18161328-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=18161328&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 18161328,
"ref": "C",
"alt": "T",
"effect": "missense_variant,splice_region_variant",
"transcript": "NM_001439117.1",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001364614.2",
"protein_id": "NP_001351543.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 822,
"cds_start": 89,
"cds_end": null,
"cds_length": 2469,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000650836.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001364614.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "ENST00000650836.2",
"protein_id": "ENSP00000499208.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 822,
"cds_start": 89,
"cds_end": null,
"cds_length": 2469,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001364614.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000650836.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.-19+5915C>T",
"hgvs_p": null,
"transcript": "ENST00000546309.6",
"protein_id": "ENSP00000442670.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 113,
"cds_start": null,
"cds_end": null,
"cds_length": 342,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000546309.6"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439117.1",
"protein_id": "NP_001426046.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 832,
"cds_start": 89,
"cds_end": null,
"cds_length": 2499,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439117.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439118.1",
"protein_id": "NP_001426047.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 831,
"cds_start": 89,
"cds_end": null,
"cds_length": 2496,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439118.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439119.1",
"protein_id": "NP_001426048.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 823,
"cds_start": 89,
"cds_end": null,
"cds_length": 2472,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439119.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "ENST00000449850.2",
"protein_id": "ENSP00000405669.2",
"transcript_support_level": 5,
"aa_start": 30,
"aa_end": null,
"aa_length": 823,
"cds_start": 89,
"cds_end": null,
"cds_length": 2472,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000449850.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "ENST00000897550.1",
"protein_id": "ENSP00000567609.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 823,
"cds_start": 89,
"cds_end": null,
"cds_length": 2472,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897550.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439130.1",
"protein_id": "NP_001426059.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 822,
"cds_start": 89,
"cds_end": null,
"cds_length": 2469,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439130.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "ENST00000897548.1",
"protein_id": "ENSP00000567607.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 822,
"cds_start": 89,
"cds_end": null,
"cds_length": 2469,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897548.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "ENST00000897549.1",
"protein_id": "ENSP00000567608.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 822,
"cds_start": 89,
"cds_end": null,
"cds_length": 2469,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897549.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "ENST00000897551.1",
"protein_id": "ENSP00000567610.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 822,
"cds_start": 89,
"cds_end": null,
"cds_length": 2469,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897551.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439120.1",
"protein_id": "NP_001426049.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 793,
"cds_start": 89,
"cds_end": null,
"cds_length": 2382,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439120.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439121.1",
"protein_id": "NP_001426050.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 792,
"cds_start": 89,
"cds_end": null,
"cds_length": 2379,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439121.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439122.1",
"protein_id": "NP_001426051.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 691,
"cds_start": 89,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439122.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439123.1",
"protein_id": "NP_001426052.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 690,
"cds_start": 89,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439123.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439124.1",
"protein_id": "NP_001426053.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 678,
"cds_start": 89,
"cds_end": null,
"cds_length": 2037,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439124.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439125.1",
"protein_id": "NP_001426054.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 677,
"cds_start": 89,
"cds_end": null,
"cds_length": 2034,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439125.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439126.1",
"protein_id": "NP_001426055.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 661,
"cds_start": 89,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439126.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439127.1",
"protein_id": "NP_001426056.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 660,
"cds_start": 89,
"cds_end": null,
"cds_length": 1983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439127.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KDM1B",
"gene_hgnc_id": 21577,
"hgvs_c": "c.89C>T",
"hgvs_p": "p.Ala30Val",
"transcript": "NM_001439128.1",
"protein_id": "NP_001426057.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 648,
"cds_start": 89,
"cds_end": null,
"cds_length": 1947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439128.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
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