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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-26366990-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=26366990&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 26366990,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000377708.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-66-1000C>T",
"hgvs_p": null,
"transcript": "NM_007047.5",
"protein_id": "NP_008978.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3776,
"mane_select": "ENST00000377708.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-66-1000C>T",
"hgvs_p": null,
"transcript": "ENST00000377708.7",
"protein_id": "ENSP00000366937.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3776,
"mane_select": "NM_007047.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-76-985C>T",
"hgvs_p": null,
"transcript": "NM_001197247.3",
"protein_id": "NP_001184176.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4068,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-66-1000C>T",
"hgvs_p": null,
"transcript": "ENST00000356386.6",
"protein_id": "ENSP00000348751.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-66-1000C>T",
"hgvs_p": null,
"transcript": "ENST00000396948.5",
"protein_id": "ENSP00000380152.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1494,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-76-985C>T",
"hgvs_p": null,
"transcript": "ENST00000527422.5",
"protein_id": "ENSP00000432138.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1460,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.17-1575C>T",
"hgvs_p": null,
"transcript": "NM_001197248.3",
"protein_id": "NP_001184177.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 311,
"cds_start": -4,
"cds_end": null,
"cds_length": 936,
"cdna_start": null,
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"cdna_length": 3625,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.17-1575C>T",
"hgvs_p": null,
"transcript": "ENST00000396934.7",
"protein_id": "ENSP00000380140.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 311,
"cds_start": -4,
"cds_end": null,
"cds_length": 936,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3672,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BTN3A2",
"gene_hgnc_id": 1139,
"hgvs_c": "c.-102-1000C>T",
"hgvs_p": null,
"transcript": "NM_001197249.3",
"protein_id": "NP_001184178.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 292,
"cds_start": -4,
"cds_end": null,
"cds_length": 879,
"cdna_start": null,
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"cdna_length": 3686,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 1,
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"gene_symbol": "BTN3A2",
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"hgvs_c": "c.-102-1000C>T",
"hgvs_p": null,
"transcript": "ENST00000508906.6",
"protein_id": "ENSP00000442687.1",
"transcript_support_level": 2,
"aa_start": null,
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"aa_length": 292,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "BTN3A2",
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"hgvs_c": "c.-102-1000C>T",
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"transcript": "ENST00000532865.5",
"protein_id": "ENSP00000435952.1",
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"cds_start": -4,
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},
{
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],
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"gene_symbol": "BTN3A2",
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},
{
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],
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"gene_symbol": "BTN3A2",
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"hgvs_c": "c.-102-1000C>T",
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},
{
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],
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"gene_symbol": "BTN3A2",
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"hgvs_c": "n.-66-1000C>T",
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},
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],
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},
{
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],
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},
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],
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},
{
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],
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"hgvs_c": "n.126-1000C>T",
"hgvs_p": null,
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},
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],
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "BTN3A2",
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],
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],
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],
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"intron_rank": 1,
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"gene_symbol": "BTN3A2",
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"hgvs_c": "c.-66-1000C>T",
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"transcript": "XM_006714979.5",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 1,
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"gene_symbol": "BTN3A2",
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"hgvs_c": "c.-66-1000C>T",
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"transcript": "XM_006714980.5",
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},
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}