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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-26407828-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=26407828&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 26407828,
"ref": "C",
"alt": "T",
"effect": "splice_region_variant,synonymous_variant",
"transcript": "NM_001145008.2",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "NM_007048.6",
"protein_id": "NP_008979.3",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 513,
"cds_start": 591,
"cds_end": null,
"cds_length": 1542,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3388,
"mane_select": "ENST00000289361.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007048.6"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "ENST00000289361.11",
"protein_id": "ENSP00000289361.6",
"transcript_support_level": 1,
"aa_start": 197,
"aa_end": null,
"aa_length": 513,
"cds_start": 591,
"cds_end": null,
"cds_length": 1542,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3388,
"mane_select": "NM_007048.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000289361.11"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "ENST00000476549.6",
"protein_id": "ENSP00000420010.2",
"transcript_support_level": 1,
"aa_start": 197,
"aa_end": null,
"aa_length": 352,
"cds_start": 591,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 789,
"cdna_end": null,
"cdna_length": 1758,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000476549.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.-895C>T",
"hgvs_p": null,
"transcript": "XM_047418127.1",
"protein_id": "XP_047274083.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 321,
"cds_start": null,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4942,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418127.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "ENST00000850859.1",
"protein_id": "ENSP00000520946.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 513,
"cds_start": 591,
"cds_end": null,
"cds_length": 1542,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3396,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000850859.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "ENST00000865809.1",
"protein_id": "ENSP00000535868.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 513,
"cds_start": 591,
"cds_end": null,
"cds_length": 1542,
"cdna_start": 776,
"cdna_end": null,
"cdna_length": 3239,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865809.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "ENST00000865808.1",
"protein_id": "ENSP00000535867.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 506,
"cds_start": 591,
"cds_end": null,
"cds_length": 1521,
"cdna_start": 959,
"cdna_end": null,
"cdna_length": 3413,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865808.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.435C>T",
"hgvs_p": "p.Asp145Asp",
"transcript": "NM_001145008.2",
"protein_id": "NP_001138480.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 461,
"cds_start": 435,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 765,
"cdna_end": null,
"cdna_length": 3232,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145008.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.435C>T",
"hgvs_p": "p.Asp145Asp",
"transcript": "ENST00000414912.2",
"protein_id": "ENSP00000406667.2",
"transcript_support_level": 2,
"aa_start": 145,
"aa_end": null,
"aa_length": 461,
"cds_start": 435,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 745,
"cdna_end": null,
"cdna_length": 2077,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000414912.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.435C>T",
"hgvs_p": "p.Asp145Asp",
"transcript": "ENST00000865812.1",
"protein_id": "ENSP00000535871.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 461,
"cds_start": 435,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 568,
"cdna_end": null,
"cdna_length": 3030,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865812.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.435C>T",
"hgvs_p": "p.Asp145Asp",
"transcript": "ENST00000865811.1",
"protein_id": "ENSP00000535870.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 454,
"cds_start": 435,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 728,
"cdna_end": null,
"cdna_length": 3182,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865811.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "NM_001145009.2",
"protein_id": "NP_001138481.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 378,
"cds_start": 591,
"cds_end": null,
"cds_length": 1137,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 4145,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145009.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "ENST00000425234.6",
"protein_id": "ENSP00000396684.2",
"transcript_support_level": 2,
"aa_start": 197,
"aa_end": null,
"aa_length": 378,
"cds_start": 591,
"cds_end": null,
"cds_length": 1137,
"cdna_start": 946,
"cdna_end": null,
"cdna_length": 1882,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000425234.6"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "NM_194441.3",
"protein_id": "NP_919423.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 352,
"cds_start": 591,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 751,
"cdna_end": null,
"cdna_length": 3682,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_194441.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_047418120.1",
"protein_id": "XP_047274076.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 513,
"cds_start": 591,
"cds_end": null,
"cds_length": 1542,
"cdna_start": 2158,
"cdna_end": null,
"cdna_length": 4625,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418120.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_047418121.1",
"protein_id": "XP_047274077.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 513,
"cds_start": 591,
"cds_end": null,
"cds_length": 1542,
"cdna_start": 1753,
"cdna_end": null,
"cdna_length": 4220,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418121.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_005248833.3",
"protein_id": "XP_005248890.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 506,
"cds_start": 591,
"cds_end": null,
"cds_length": 1521,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3367,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005248833.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_047418122.1",
"protein_id": "XP_047274078.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 506,
"cds_start": 591,
"cds_end": null,
"cds_length": 1521,
"cdna_start": 2158,
"cdna_end": null,
"cdna_length": 4604,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418122.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_047418123.1",
"protein_id": "XP_047274079.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 378,
"cds_start": 591,
"cds_end": null,
"cds_length": 1137,
"cdna_start": 1753,
"cdna_end": null,
"cdna_length": 4977,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418123.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_005248834.5",
"protein_id": "XP_005248891.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 352,
"cds_start": 591,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3852,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005248834.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_047418124.1",
"protein_id": "XP_047274080.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 352,
"cds_start": 591,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 2158,
"cdna_end": null,
"cdna_length": 5089,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418124.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "BTN3A1",
"gene_hgnc_id": 1138,
"hgvs_c": "c.591C>T",
"hgvs_p": "p.Asp197Asp",
"transcript": "XM_047418125.1",
"protein_id": "XP_047274081.1",
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"aa_start": 197,
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}
],
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}