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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-28276799-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=28276799&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 28276799,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001023560.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "NM_001023560.4",
"protein_id": "NP_001018854.2",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000421553.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001023560.4"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000421553.7",
"protein_id": "ENSP00000481707.1",
"transcript_support_level": 1,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001023560.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000421553.7"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "ENST00000316606.10",
"protein_id": "ENSP00000484931.1",
"transcript_support_level": 1,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000316606.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ENSG00000276302",
"gene_hgnc_id": null,
"hgvs_c": "c.133+4012C>T",
"hgvs_p": null,
"transcript": "ENST00000621053.1",
"protein_id": "ENSP00000481142.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 84,
"cds_start": null,
"cds_end": null,
"cds_length": 255,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000621053.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000619937.4",
"protein_id": "ENSP00000484018.1",
"transcript_support_level": 2,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000619937.4"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000854330.1",
"protein_id": "ENSP00000524389.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854330.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000934902.1",
"protein_id": "ENSP00000604961.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934902.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000951043.1",
"protein_id": "ENSP00000621102.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951043.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000951044.1",
"protein_id": "ENSP00000621103.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951044.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000951045.1",
"protein_id": "ENSP00000621104.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951045.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1143C>T",
"hgvs_p": "p.Leu381Leu",
"transcript": "ENST00000951046.1",
"protein_id": "ENSP00000621105.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 479,
"cds_start": 1143,
"cds_end": null,
"cds_length": 1440,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951046.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1140C>T",
"hgvs_p": "p.Leu380Leu",
"transcript": "NM_001111039.3",
"protein_id": "NP_001104509.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 478,
"cds_start": 1140,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001111039.3"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1140C>T",
"hgvs_p": "p.Leu380Leu",
"transcript": "ENST00000623276.3",
"protein_id": "ENSP00000485228.1",
"transcript_support_level": 3,
"aa_start": 380,
"aa_end": null,
"aa_length": 478,
"cds_start": 1140,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000623276.3"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1140C>T",
"hgvs_p": "p.Leu380Leu",
"transcript": "ENST00000854327.1",
"protein_id": "ENSP00000524386.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 478,
"cds_start": 1140,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854327.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.1140C>T",
"hgvs_p": "p.Leu380Leu",
"transcript": "ENST00000951047.1",
"protein_id": "ENSP00000621106.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 478,
"cds_start": 1140,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951047.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "NM_001287421.2",
"protein_id": "NP_001274350.1",
"transcript_support_level": null,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001287421.2"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "NM_152736.6",
"protein_id": "NP_689949.3",
"transcript_support_level": null,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_152736.6"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "ENST00000614088.1",
"protein_id": "ENSP00000479314.1",
"transcript_support_level": 3,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000614088.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "ENST00000854328.1",
"protein_id": "ENSP00000524387.1",
"transcript_support_level": null,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854328.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "ENST00000854329.1",
"protein_id": "ENSP00000524388.1",
"transcript_support_level": null,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000854329.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "ENST00000934901.1",
"protein_id": "ENSP00000604960.1",
"transcript_support_level": null,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934901.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZSCAN26",
"gene_hgnc_id": 12978,
"hgvs_c": "c.738C>T",
"hgvs_p": "p.Leu246Leu",
"transcript": "ENST00000934903.1",
"protein_id": "ENSP00000604962.1",
"transcript_support_level": null,
"aa_start": 246,
"aa_end": null,
"aa_length": 344,
"cds_start": 738,
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"splice_prediction_selected": "Benign",
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{
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"BP6_Moderate",
"BP7"
],
"verdict": "Likely_benign",
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{
"score": -4,
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"BP6_Moderate"
],
"verdict": "Likely_benign",
"transcript": "ENST00000621053.1",
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],
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}
],
"clinvar_disease": "not specified",
"clinvar_classification": "Likely benign",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "LB:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Likely benign",
"custom_annotations": null
}
],
"message": null
}