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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-28996134-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=28996134&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 28996134,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000377179.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.868C>G",
"hgvs_p": "p.Leu290Val",
"transcript": "NM_001382360.1",
"protein_id": "NP_001369289.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 666,
"cds_start": 868,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 1436,
"cdna_end": null,
"cdna_length": 2782,
"mane_select": "ENST00000377179.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.868C>G",
"hgvs_p": "p.Leu290Val",
"transcript": "ENST00000377179.4",
"protein_id": "ENSP00000366384.3",
"transcript_support_level": 5,
"aa_start": 290,
"aa_end": null,
"aa_length": 666,
"cds_start": 868,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 1436,
"cdna_end": null,
"cdna_length": 2782,
"mane_select": "NM_001382360.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.868C>G",
"hgvs_p": "p.Leu290Val",
"transcript": "NM_001010877.5",
"protein_id": "NP_001010877.2",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 666,
"cds_start": 868,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 1275,
"cdna_end": null,
"cdna_length": 2621,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.724C>G",
"hgvs_p": "p.Leu242Val",
"transcript": "NM_001350637.4",
"protein_id": "NP_001337566.1",
"transcript_support_level": null,
"aa_start": 242,
"aa_end": null,
"aa_length": 618,
"cds_start": 724,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 1384,
"cdna_end": null,
"cdna_length": 2730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.967C>G",
"hgvs_p": "p.Leu323Val",
"transcript": "XM_005249019.5",
"protein_id": "XP_005249076.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 699,
"cds_start": 967,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1386,
"cdna_end": null,
"cdna_length": 2732,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.967C>G",
"hgvs_p": "p.Leu323Val",
"transcript": "XM_006715067.4",
"protein_id": "XP_006715130.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 699,
"cds_start": 967,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1535,
"cdna_end": null,
"cdna_length": 2881,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.967C>G",
"hgvs_p": "p.Leu323Val",
"transcript": "XM_011514510.3",
"protein_id": "XP_011512812.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 699,
"cds_start": 967,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 2520,
"cdna_end": null,
"cdna_length": 3866,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.967C>G",
"hgvs_p": "p.Leu323Val",
"transcript": "XM_011514511.3",
"protein_id": "XP_011512813.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 699,
"cds_start": 967,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 2211,
"cdna_end": null,
"cdna_length": 3557,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.967C>G",
"hgvs_p": "p.Leu323Val",
"transcript": "XM_017010756.2",
"protein_id": "XP_016866245.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 699,
"cds_start": 967,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1272,
"cdna_end": null,
"cdna_length": 2618,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.967C>G",
"hgvs_p": "p.Leu323Val",
"transcript": "XM_017010757.2",
"protein_id": "XP_016866246.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 699,
"cds_start": 967,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1123,
"cdna_end": null,
"cdna_length": 2469,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.943C>G",
"hgvs_p": "p.Leu315Val",
"transcript": "XM_011514512.3",
"protein_id": "XP_011512814.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 691,
"cds_start": 943,
"cds_end": null,
"cds_length": 2076,
"cdna_start": 2496,
"cdna_end": null,
"cdna_length": 3842,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.943C>G",
"hgvs_p": "p.Leu315Val",
"transcript": "XM_047418659.1",
"protein_id": "XP_047274615.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 691,
"cds_start": 943,
"cds_end": null,
"cds_length": 2076,
"cdna_start": 1511,
"cdna_end": null,
"cdna_length": 2857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.943C>G",
"hgvs_p": "p.Leu315Val",
"transcript": "XM_047418660.1",
"protein_id": "XP_047274616.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 691,
"cds_start": 943,
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"cds_length": 2076,
"cdna_start": 1362,
"cdna_end": null,
"cdna_length": 2708,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.943C>G",
"hgvs_p": "p.Leu315Val",
"transcript": "XM_047418661.1",
"protein_id": "XP_047274617.1",
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.943C>G",
"hgvs_p": "p.Leu315Val",
"transcript": "XM_047418662.1",
"protein_id": "XP_047274618.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 691,
"cds_start": 943,
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"cdna_start": 1099,
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"cdna_length": 2445,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.940C>G",
"hgvs_p": "p.Leu314Val",
"transcript": "XM_011514513.3",
"protein_id": "XP_011512815.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.916C>G",
"hgvs_p": "p.Leu306Val",
"transcript": "XM_047418663.1",
"protein_id": "XP_047274619.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 682,
"cds_start": 916,
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"cdna_start": 1484,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "L",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.916C>G",
"hgvs_p": "p.Leu306Val",
"transcript": "XM_047418664.1",
"protein_id": "XP_047274620.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 682,
"cds_start": 916,
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"cdna_start": 1335,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 7,
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"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "ZNF311",
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"hgvs_c": "c.916C>G",
"hgvs_p": "p.Leu306Val",
"transcript": "XM_047418665.1",
"protein_id": "XP_047274621.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.892C>G",
"hgvs_p": "p.Leu298Val",
"transcript": "XM_011514514.3",
"protein_id": "XP_011512816.1",
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"aa_start": 298,
"aa_end": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 7,
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"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.892C>G",
"hgvs_p": "p.Leu298Val",
"transcript": "XM_047418666.1",
"protein_id": "XP_047274622.1",
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"aa_start": 298,
"aa_end": null,
"aa_length": 674,
"cds_start": 892,
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"cds_length": 2025,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
"gene_hgnc_id": 13847,
"hgvs_c": "c.892C>G",
"hgvs_p": "p.Leu298Val",
"transcript": "XM_047418667.1",
"protein_id": "XP_047274623.1",
"transcript_support_level": null,
"aa_start": 298,
"aa_end": null,
"aa_length": 674,
"cds_start": 892,
"cds_end": null,
"cds_length": 2025,
"cdna_start": 1448,
"cdna_end": null,
"cdna_length": 2794,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "L",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF311",
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}