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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-29608616-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=29608616&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 29608616,
"ref": "A",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "ENST00000377034.9",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1977T>C",
"hgvs_p": "p.Phe659Phe",
"transcript": "NM_001470.4",
"protein_id": "NP_001461.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 961,
"cds_start": 1977,
"cds_end": null,
"cds_length": 2886,
"cdna_start": 2311,
"cdna_end": null,
"cdna_length": 4525,
"mane_select": "ENST00000377034.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1977T>C",
"hgvs_p": "p.Phe659Phe",
"transcript": "ENST00000377034.9",
"protein_id": "ENSP00000366233.4",
"transcript_support_level": 1,
"aa_start": 659,
"aa_end": null,
"aa_length": 961,
"cds_start": 1977,
"cds_end": null,
"cds_length": 2886,
"cdna_start": 2311,
"cdna_end": null,
"cdna_length": 4525,
"mane_select": "NM_001470.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1626T>C",
"hgvs_p": "p.Phe542Phe",
"transcript": "ENST00000377012.9",
"protein_id": "ENSP00000366211.4",
"transcript_support_level": 1,
"aa_start": 542,
"aa_end": null,
"aa_length": 844,
"cds_start": 1626,
"cds_end": null,
"cds_length": 2535,
"cdna_start": 1848,
"cdna_end": null,
"cdna_length": 4062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1992T>C",
"hgvs_p": "p.Phe664Phe",
"transcript": "ENST00000476670.3",
"protein_id": "ENSP00000417332.2",
"transcript_support_level": 4,
"aa_start": 664,
"aa_end": null,
"aa_length": 966,
"cds_start": 1992,
"cds_end": null,
"cds_length": 2901,
"cdna_start": 2078,
"cdna_end": null,
"cdna_length": 4118,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1977T>C",
"hgvs_p": "p.Phe659Phe",
"transcript": "ENST00000462632.6",
"protein_id": "ENSP00000419755.2",
"transcript_support_level": 4,
"aa_start": 659,
"aa_end": null,
"aa_length": 961,
"cds_start": 1977,
"cds_end": null,
"cds_length": 2886,
"cdna_start": 2116,
"cdna_end": null,
"cdna_length": 4326,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1977T>C",
"hgvs_p": "p.Phe659Phe",
"transcript": "ENST00000706533.1",
"protein_id": "ENSP00000516435.1",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 961,
"cds_start": 1977,
"cds_end": null,
"cds_length": 2886,
"cdna_start": 2142,
"cdna_end": null,
"cdna_length": 4310,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1791T>C",
"hgvs_p": "p.Phe597Phe",
"transcript": "NM_021904.4",
"protein_id": "NP_068704.2",
"transcript_support_level": null,
"aa_start": 597,
"aa_end": null,
"aa_length": 899,
"cds_start": 1791,
"cds_end": null,
"cds_length": 2700,
"cdna_start": 2125,
"cdna_end": null,
"cdna_length": 4339,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1791T>C",
"hgvs_p": "p.Phe597Phe",
"transcript": "ENST00000377016.8",
"protein_id": "ENSP00000366215.4",
"transcript_support_level": 5,
"aa_start": 597,
"aa_end": null,
"aa_length": 899,
"cds_start": 1791,
"cds_end": null,
"cds_length": 2700,
"cdna_start": 2077,
"cdna_end": null,
"cdna_length": 4299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1626T>C",
"hgvs_p": "p.Phe542Phe",
"transcript": "NM_021903.3",
"protein_id": "NP_068703.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 844,
"cds_start": 1626,
"cds_end": null,
"cds_length": 2535,
"cdna_start": 1848,
"cdna_end": null,
"cdna_length": 4062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1626T>C",
"hgvs_p": "p.Phe542Phe",
"transcript": "ENST00000355973.7",
"protein_id": "ENSP00000348248.3",
"transcript_support_level": 2,
"aa_start": 542,
"aa_end": null,
"aa_length": 844,
"cds_start": 1626,
"cds_end": null,
"cds_length": 2535,
"cdna_start": 1873,
"cdna_end": null,
"cdna_length": 3506,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1446T>C",
"hgvs_p": "p.Phe482Phe",
"transcript": "NM_001319053.2",
"protein_id": "NP_001305982.1",
"transcript_support_level": null,
"aa_start": 482,
"aa_end": null,
"aa_length": 784,
"cds_start": 1446,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 2247,
"cdna_end": null,
"cdna_length": 4461,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1992T>C",
"hgvs_p": "p.Phe664Phe",
"transcript": "XM_005248982.3",
"protein_id": "XP_005249039.1",
"transcript_support_level": null,
"aa_start": 664,
"aa_end": null,
"aa_length": 966,
"cds_start": 1992,
"cds_end": null,
"cds_length": 2901,
"cdna_start": 2078,
"cdna_end": null,
"cdna_length": 4292,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1806T>C",
"hgvs_p": "p.Phe602Phe",
"transcript": "XM_006715047.5",
"protein_id": "XP_006715110.1",
"transcript_support_level": null,
"aa_start": 602,
"aa_end": null,
"aa_length": 904,
"cds_start": 1806,
"cds_end": null,
"cds_length": 2715,
"cdna_start": 1870,
"cdna_end": null,
"cdna_length": 4084,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1785T>C",
"hgvs_p": "p.Phe595Phe",
"transcript": "XM_011514453.4",
"protein_id": "XP_011512755.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 897,
"cds_start": 1785,
"cds_end": null,
"cds_length": 2694,
"cdna_start": 1848,
"cdna_end": null,
"cdna_length": 4062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1446T>C",
"hgvs_p": "p.Phe482Phe",
"transcript": "XM_047418591.1",
"protein_id": "XP_047274547.1",
"transcript_support_level": null,
"aa_start": 482,
"aa_end": null,
"aa_length": 784,
"cds_start": 1446,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 2370,
"cdna_end": null,
"cdna_length": 4584,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1428T>C",
"hgvs_p": "p.Phe476Phe",
"transcript": "XM_024446392.2",
"protein_id": "XP_024302160.1",
"transcript_support_level": null,
"aa_start": 476,
"aa_end": null,
"aa_length": 778,
"cds_start": 1428,
"cds_end": null,
"cds_length": 2337,
"cdna_start": 1526,
"cdna_end": null,
"cdna_length": 3740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "c.1992T>C",
"hgvs_p": "p.Phe664Phe",
"transcript": "XM_011514455.2",
"protein_id": "XP_011512757.1",
"transcript_support_level": null,
"aa_start": 664,
"aa_end": null,
"aa_length": 680,
"cds_start": 1992,
"cds_end": null,
"cds_length": 2043,
"cdna_start": 2061,
"cdna_end": null,
"cdna_length": 3449,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "n.*1384T>C",
"hgvs_p": null,
"transcript": "ENST00000472823.5",
"protein_id": "ENSP00000419356.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4286,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "n.503T>C",
"hgvs_p": null,
"transcript": "ENST00000473774.1",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 582,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "n.245T>C",
"hgvs_p": null,
"transcript": "ENST00000489839.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 407,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "n.*1499T>C",
"hgvs_p": null,
"transcript": "ENST00000491829.5",
"protein_id": "ENSP00000417478.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4212,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "n.*89T>C",
"hgvs_p": null,
"transcript": "ENST00000494877.5",
"protein_id": "ENSP00000419061.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2364,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GABBR1",
"gene_hgnc_id": 4070,
"hgvs_c": "n.*1384T>C",
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"splice_prediction_selected": "Benign",
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{
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"verdict": "Benign",
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"clinvar_disease": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"custom_annotations": null
}
],
"message": null
}