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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 6-31940984-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=31940984&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "6",
      "pos": 31940984,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "ENST00000299367.10",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.1219+1664T>C",
          "hgvs_p": null,
          "transcript": "NM_000063.6",
          "protein_id": "NP_000054.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 752,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2259,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2610,
          "mane_select": "ENST00000299367.10",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.1219+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000299367.10",
          "protein_id": "ENSP00000299367.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 752,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2259,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2610,
          "mane_select": "NM_000063.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000244255",
          "gene_hgnc_id": null,
          "hgvs_c": "c.760+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000456570.5",
          "protein_id": "ENSP00000410815.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1266,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3801,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3874,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000244255",
          "gene_hgnc_id": null,
          "hgvs_c": "c.673+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000477310.1",
          "protein_id": "ENSP00000418996.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1115,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3348,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3377,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.1132+1664T>C",
          "hgvs_p": null,
          "transcript": "NM_001282458.2",
          "protein_id": "NP_001269387.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 723,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2172,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2638,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 8,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.1033+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000447952.7",
          "protein_id": "ENSP00000391354.3",
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2617,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.1219+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000695638.1",
          "protein_id": "ENSP00000512076.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 678,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2037,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2252,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.823+1664T>C",
          "hgvs_p": null,
          "transcript": "NM_001145903.3",
          "protein_id": "NP_001139375.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 620,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1863,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2214,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.823+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000442278.6",
          "protein_id": "ENSP00000395683.2",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 620,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1863,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2434,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 9,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.814+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000695637.1",
          "protein_id": "ENSP00000512074.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 617,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1854,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3019,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.823+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000695644.1",
          "protein_id": "ENSP00000512079.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 560,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1683,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2139,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.580+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000497706.6",
          "protein_id": "ENSP00000417482.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 539,
          "cds_start": -4,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 14,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.577+1664T>C",
          "hgvs_p": null,
          "transcript": "NM_001178063.3",
          "protein_id": "NP_001171534.1",
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          "aa_start": null,
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          "aa_length": 538,
          "cds_start": -4,
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          "cds_length": 1617,
          "cdna_start": null,
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          "cdna_length": 2000,
          "mane_select": null,
          "mane_plus": null,
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          "feature": null
        },
        {
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          "canonical": false,
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          "intron_rank": 5,
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          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.577+1664T>C",
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          "transcript": "ENST00000452323.7",
          "protein_id": "ENSP00000392322.2",
          "transcript_support_level": 2,
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          "aa_length": 538,
          "cds_start": -4,
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          "cdna_start": null,
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          "cdna_length": 2000,
          "mane_select": null,
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          "feature": null
        },
        {
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          "canonical": false,
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          "strand": true,
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          ],
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          "intron_rank": 5,
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          "gene_symbol": "C2",
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          "hgvs_c": "c.538+1664T>C",
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        {
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          "gene_symbol": "C2",
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          "hgvs_c": "c.481+1664T>C",
          "hgvs_p": null,
          "transcript": "NM_001282457.2",
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          "cdna_start": null,
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          "cdna_length": 2059,
          "mane_select": null,
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
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          "consequences": [
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          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "c.481+1664T>C",
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          "transcript": "ENST00000469372.5",
          "protein_id": "ENSP00000418923.1",
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          "mane_select": null,
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          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 18,
          "intron_rank": 9,
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          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "n.1219+1664T>C",
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          "transcript": "ENST00000468407.2",
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        {
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          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "n.*932+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000482060.5",
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        },
        {
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          "strand": true,
          "consequences": [
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          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "n.385+1664T>C",
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          "transcript": "ENST00000485690.5",
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          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "C2",
          "gene_hgnc_id": 1248,
          "hgvs_c": "n.1495+1664T>C",
          "hgvs_p": null,
          "transcript": "ENST00000486124.5",
          "protein_id": null,
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          "cds_start": -4,
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      ],
      "gene_symbol": "C2",
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      "dbsnp": "rs497239",
      "frequency_reference_population": 0.11711593,
      "hom_count_reference_population": 1220,
      "allele_count_reference_population": 17822,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": 0.117116,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": 17822,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": 1220,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.9300000071525574,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.93,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.082,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -12,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000299367.10",
          "gene_symbol": "C2",
          "hgnc_id": 1248,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1219+1664T>C",
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        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000456570.5",
          "gene_symbol": "ENSG00000244255",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.760+1664T>C",
          "hgvs_p": null
        },
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000630806.1",
          "gene_symbol": "C2-AS1",
          "hgnc_id": 49464,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.540+201A>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}