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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-33320452-CTT-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=33320452&ref=CTT&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 33320452,
"ref": "CTT",
"alt": "C",
"effect": "frameshift_variant",
"transcript": "NM_001141970.2",
"consequences": [
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "NM_001141969.2",
"protein_id": "NP_001135441.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000374542.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001141969.2"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000374542.10",
"protein_id": "ENSP00000363668.5",
"transcript_support_level": 1,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001141969.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374542.10"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000266000.10",
"protein_id": "ENSP00000266000.6",
"transcript_support_level": 1,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000266000.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "n.7_8delAA",
"hgvs_p": null,
"transcript": "ENST00000490173.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000490173.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1213_1214delAA",
"hgvs_p": "p.Lys405fs",
"transcript": "NM_001141970.2",
"protein_id": "NP_001135442.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 752,
"cds_start": 1213,
"cds_end": null,
"cds_length": 2259,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001141970.2"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1213_1214delAA",
"hgvs_p": "p.Lys405fs",
"transcript": "ENST00000706094.1",
"protein_id": "ENSP00000516212.1",
"transcript_support_level": null,
"aa_start": 405,
"aa_end": null,
"aa_length": 752,
"cds_start": 1213,
"cds_end": null,
"cds_length": 2259,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706094.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000859776.1",
"protein_id": "ENSP00000529835.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 750,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859776.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "NM_001350.5",
"protein_id": "NP_001341.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001350.5"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000859774.1",
"protein_id": "ENSP00000529833.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859774.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000859781.1",
"protein_id": "ENSP00000529840.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859781.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000932661.1",
"protein_id": "ENSP00000602720.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932661.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000932667.1",
"protein_id": "ENSP00000602726.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932667.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000932668.1",
"protein_id": "ENSP00000602727.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932668.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000932669.1",
"protein_id": "ENSP00000602728.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932669.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000932670.1",
"protein_id": "ENSP00000602729.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932670.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000932671.1",
"protein_id": "ENSP00000602730.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 740,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2223,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932671.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000859780.1",
"protein_id": "ENSP00000529839.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 738,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859780.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1156_1157delAA",
"hgvs_p": "p.Lys386fs",
"transcript": "ENST00000932663.1",
"protein_id": "ENSP00000602722.1",
"transcript_support_level": null,
"aa_start": 386,
"aa_end": null,
"aa_length": 733,
"cds_start": 1156,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932663.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1153_1154delAA",
"hgvs_p": "p.Lys385fs",
"transcript": "ENST00000932664.1",
"protein_id": "ENSP00000602723.1",
"transcript_support_level": null,
"aa_start": 385,
"aa_end": null,
"aa_length": 732,
"cds_start": 1153,
"cds_end": null,
"cds_length": 2199,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932664.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1108_1109delAA",
"hgvs_p": "p.Lys370fs",
"transcript": "ENST00000859779.1",
"protein_id": "ENSP00000529838.1",
"transcript_support_level": null,
"aa_start": 370,
"aa_end": null,
"aa_length": 717,
"cds_start": 1108,
"cds_end": null,
"cds_length": 2154,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859779.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1108_1109delAA",
"hgvs_p": "p.Lys370fs",
"transcript": "ENST00000932666.1",
"protein_id": "ENSP00000602725.1",
"transcript_support_level": null,
"aa_start": 370,
"aa_end": null,
"aa_length": 717,
"cds_start": 1108,
"cds_end": null,
"cds_length": 2154,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932666.1"
},
{
"aa_ref": "K",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAXX",
"gene_hgnc_id": 2681,
"hgvs_c": "c.1177_1178delAA",
"hgvs_p": "p.Lys393fs",
"transcript": "ENST00000620164.4",
"protein_id": "ENSP00000482399.1",
"transcript_support_level": 5,
"aa_start": 393,
"aa_end": null,
"aa_length": 688,
"cds_start": 1177,
"cds_end": null,
"cds_length": 2067,
"cdna_start": null,
"cdna_end": null,
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}
],
"message": null
}