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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-35411148-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=35411148&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 35411148,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_006238.5",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "NM_006238.5",
"protein_id": "NP_006229.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000360694.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006238.5"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000360694.8",
"protein_id": "ENSP00000353916.3",
"transcript_support_level": 2,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006238.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360694.8"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "NM_001171818.2",
"protein_id": "NP_001165289.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001171818.2"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000311565.4",
"protein_id": "ENSP00000310928.4",
"transcript_support_level": 5,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000311565.4"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875334.1",
"protein_id": "ENSP00000545393.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875334.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875335.1",
"protein_id": "ENSP00000545394.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875335.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875336.1",
"protein_id": "ENSP00000545395.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875336.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875337.1",
"protein_id": "ENSP00000545396.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875337.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875338.1",
"protein_id": "ENSP00000545397.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875338.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875339.1",
"protein_id": "ENSP00000545398.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875339.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875340.1",
"protein_id": "ENSP00000545399.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875340.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875341.1",
"protein_id": "ENSP00000545400.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875341.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875342.1",
"protein_id": "ENSP00000545401.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875342.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875343.1",
"protein_id": "ENSP00000545402.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875343.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875344.1",
"protein_id": "ENSP00000545403.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875344.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875346.1",
"protein_id": "ENSP00000545405.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875346.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875347.1",
"protein_id": "ENSP00000545406.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875347.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875348.1",
"protein_id": "ENSP00000545407.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875348.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875349.1",
"protein_id": "ENSP00000545408.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875349.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875350.1",
"protein_id": "ENSP00000545409.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875350.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875351.1",
"protein_id": "ENSP00000545410.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875351.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.61G>T",
"hgvs_p": "p.Ala21Ser",
"transcript": "ENST00000875352.1",
"protein_id": "ENSP00000545411.1",
"transcript_support_level": null,
"aa_start": 21,
"aa_end": null,
"aa_length": 441,
"cds_start": 61,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875352.1"
},
{
"aa_ref": "A",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
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}
],
"message": null
}