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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-36976703-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=36976703&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 36976703,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000373627.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "NM_001271641.2",
"protein_id": "NP_001258570.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 389,
"cds_start": -4,
"cds_end": null,
"cds_length": 1170,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1955,
"mane_select": "ENST00000373627.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000373627.10",
"protein_id": "ENSP00000362730.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 389,
"cds_start": -4,
"cds_end": null,
"cds_length": 1170,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1955,
"mane_select": "NM_001271641.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000373616.9",
"protein_id": "ENSP00000362718.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 372,
"cds_start": -4,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2006,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "n.1602A>G",
"hgvs_p": null,
"transcript": "ENST00000695052.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6152,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "NM_001410897.1",
"protein_id": "NP_001397826.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 427,
"cds_start": -4,
"cds_end": null,
"cds_length": 1284,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3329,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "NM_001410899.1",
"protein_id": "NP_001397828.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 410,
"cds_start": -4,
"cds_end": null,
"cds_length": 1233,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000460219.3",
"protein_id": "ENSP00000419739.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 410,
"cds_start": -4,
"cds_end": null,
"cds_length": 1233,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1620,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695055.1",
"protein_id": "ENSP00000511669.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 389,
"cds_start": -4,
"cds_end": null,
"cds_length": 1170,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4286,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695068.1",
"protein_id": "ENSP00000511675.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 380,
"cds_start": -4,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1909,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "NM_014341.2",
"protein_id": "NP_055156.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 372,
"cds_start": -4,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2265,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695075.1",
"protein_id": "ENSP00000511682.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 369,
"cds_start": -4,
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"cds_length": 1110,
"cdna_start": null,
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"cdna_length": 2206,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.614+966A>G",
"hgvs_p": null,
"transcript": "ENST00000695071.1",
"protein_id": "ENSP00000511678.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.701+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695067.1",
"protein_id": "ENSP00000511674.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 351,
"cds_start": -4,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 5,
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"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.617+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695070.1",
"protein_id": "ENSP00000511677.1",
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},
{
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"strand": false,
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],
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"intron_rank": 6,
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"gene_symbol": "MTCH1",
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"hgvs_c": "c.701+496A>G",
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"transcript": "ENST00000695074.1",
"protein_id": "ENSP00000511681.1",
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.365+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695044.1",
"protein_id": "ENSP00000511660.1",
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},
{
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],
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"gene_symbol": "MTCH1",
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"hgvs_c": "c.365+496A>G",
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"transcript": "ENST00000695045.1",
"protein_id": "ENSP00000511661.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "c.91-105A>G",
"hgvs_p": null,
"transcript": "ENST00000418541.6",
"protein_id": "ENSP00000399187.2",
"transcript_support_level": 3,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "n.907+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695043.1",
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},
{
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"strand": false,
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],
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"intron_rank": 5,
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"gene_symbol": "MTCH1",
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"transcript": "ENST00000695046.1",
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"hgvs_c": "n.*387+496A>G",
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"transcript": "ENST00000695047.1",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "n.1106+496A>G",
"hgvs_p": null,
"transcript": "ENST00000695048.1",
"protein_id": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MTCH1",
"gene_hgnc_id": 17586,
"hgvs_c": "n.702-426A>G",
"hgvs_p": null,
"transcript": "ENST00000695049.1",
"protein_id": "ENSP00000511664.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
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},
{
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