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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-39864335-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=39864335&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 39864335,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000274867.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.259-98A>G",
"hgvs_p": null,
"transcript": "NM_001201427.2",
"protein_id": "NP_001188356.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1068,
"cds_start": -4,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6185,
"mane_select": "ENST00000274867.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.259-98A>G",
"hgvs_p": null,
"transcript": "ENST00000274867.9",
"protein_id": "ENSP00000274867.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1068,
"cds_start": -4,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6185,
"mane_select": "NM_001201427.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.259-98A>G",
"hgvs_p": null,
"transcript": "ENST00000538976.5",
"protein_id": "ENSP00000437808.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1067,
"cds_start": -4,
"cds_end": null,
"cds_length": 3204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6247,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "n.405-98A>G",
"hgvs_p": null,
"transcript": "ENST00000491083.2",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.259-98A>G",
"hgvs_p": null,
"transcript": "ENST00000633794.1",
"protein_id": "ENSP00000488831.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1077,
"cds_start": -4,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3871,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.259-98A>G",
"hgvs_p": null,
"transcript": "ENST00000398904.6",
"protein_id": "ENSP00000381876.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1068,
"cds_start": -4,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
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"cdna_length": 6224,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.259-98A>G",
"hgvs_p": null,
"transcript": "NM_015345.4",
"protein_id": "NP_056160.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1067,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 6256,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "n.*171-98A>G",
"hgvs_p": null,
"transcript": "ENST00000494405.2",
"protein_id": "ENSP00000488196.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 794,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "DAAM2-AS1",
"gene_hgnc_id": 40830,
"hgvs_c": "n.260-15443T>C",
"hgvs_p": null,
"transcript": "ENST00000837191.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 2,
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"gene_symbol": "DAAM2-AS1",
"gene_hgnc_id": 40830,
"hgvs_c": "n.263-15443T>C",
"hgvs_p": null,
"transcript": "ENST00000837192.1",
"protein_id": null,
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"aa_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 3,
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"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.556-98A>G",
"hgvs_p": null,
"transcript": "XM_006715039.4",
"protein_id": "XP_006715102.3",
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},
{
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],
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},
{
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],
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"gene_symbol": "DAAM2",
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],
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],
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],
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],
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"hgvs_c": "c.259-98A>G",
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"transcript": "XM_006715043.3",
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],
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"transcript": "XM_047418536.1",
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},
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],
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}
],
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}