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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-39901450-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=39901450&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 39901450,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001201427.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "NM_001201427.2",
"protein_id": "NP_001188356.1",
"transcript_support_level": null,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000274867.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001201427.2"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "ENST00000274867.9",
"protein_id": "ENSP00000274867.4",
"transcript_support_level": 1,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001201427.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000274867.9"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2957G>A",
"hgvs_p": "p.Arg986Gln",
"transcript": "ENST00000538976.5",
"protein_id": "ENSP00000437808.1",
"transcript_support_level": 1,
"aa_start": 986,
"aa_end": null,
"aa_length": 1067,
"cds_start": 2957,
"cds_end": null,
"cds_length": 3204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000538976.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "n.3655G>A",
"hgvs_p": null,
"transcript": "ENST00000631498.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000631498.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "MOCS1",
"gene_hgnc_id": 7190,
"hgvs_c": "n.*116-1575C>T",
"hgvs_p": null,
"transcript": "ENST00000373181.8",
"protein_id": "ENSP00000362277.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000373181.8"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2987G>A",
"hgvs_p": "p.Arg996Gln",
"transcript": "ENST00000633794.1",
"protein_id": "ENSP00000488831.1",
"transcript_support_level": 5,
"aa_start": 996,
"aa_end": null,
"aa_length": 1077,
"cds_start": 2987,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000633794.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2987G>A",
"hgvs_p": "p.Arg996Gln",
"transcript": "ENST00000853742.1",
"protein_id": "ENSP00000523801.1",
"transcript_support_level": null,
"aa_start": 996,
"aa_end": null,
"aa_length": 1077,
"cds_start": 2987,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853742.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2987G>A",
"hgvs_p": "p.Arg996Gln",
"transcript": "ENST00000853743.1",
"protein_id": "ENSP00000523802.1",
"transcript_support_level": null,
"aa_start": 996,
"aa_end": null,
"aa_length": 1077,
"cds_start": 2987,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853743.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2987G>A",
"hgvs_p": "p.Arg996Gln",
"transcript": "ENST00000853744.1",
"protein_id": "ENSP00000523803.1",
"transcript_support_level": null,
"aa_start": 996,
"aa_end": null,
"aa_length": 1077,
"cds_start": 2987,
"cds_end": null,
"cds_length": 3234,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853744.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2981G>A",
"hgvs_p": "p.Arg994Gln",
"transcript": "ENST00000853741.1",
"protein_id": "ENSP00000523800.1",
"transcript_support_level": null,
"aa_start": 994,
"aa_end": null,
"aa_length": 1075,
"cds_start": 2981,
"cds_end": null,
"cds_length": 3228,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853741.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "ENST00000398904.6",
"protein_id": "ENSP00000381876.2",
"transcript_support_level": 5,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398904.6"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "ENST00000853736.1",
"protein_id": "ENSP00000523795.1",
"transcript_support_level": null,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853736.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "ENST00000853745.1",
"protein_id": "ENSP00000523804.1",
"transcript_support_level": null,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853745.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "ENST00000924855.1",
"protein_id": "ENSP00000594914.1",
"transcript_support_level": null,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924855.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 25,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2960G>A",
"hgvs_p": "p.Arg987Gln",
"transcript": "ENST00000961720.1",
"protein_id": "ENSP00000631779.1",
"transcript_support_level": null,
"aa_start": 987,
"aa_end": null,
"aa_length": 1068,
"cds_start": 2960,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961720.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2957G>A",
"hgvs_p": "p.Arg986Gln",
"transcript": "NM_015345.4",
"protein_id": "NP_056160.2",
"transcript_support_level": null,
"aa_start": 986,
"aa_end": null,
"aa_length": 1067,
"cds_start": 2957,
"cds_end": null,
"cds_length": 3204,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015345.4"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2954G>A",
"hgvs_p": "p.Arg985Gln",
"transcript": "ENST00000853740.1",
"protein_id": "ENSP00000523799.1",
"transcript_support_level": null,
"aa_start": 985,
"aa_end": null,
"aa_length": 1066,
"cds_start": 2954,
"cds_end": null,
"cds_length": 3201,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853740.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2879G>A",
"hgvs_p": "p.Arg960Gln",
"transcript": "ENST00000853739.1",
"protein_id": "ENSP00000523798.1",
"transcript_support_level": null,
"aa_start": 960,
"aa_end": null,
"aa_length": 1041,
"cds_start": 2879,
"cds_end": null,
"cds_length": 3126,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853739.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2873G>A",
"hgvs_p": "p.Arg958Gln",
"transcript": "ENST00000853737.1",
"protein_id": "ENSP00000523796.1",
"transcript_support_level": null,
"aa_start": 958,
"aa_end": null,
"aa_length": 1039,
"cds_start": 2873,
"cds_end": null,
"cds_length": 3120,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853737.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2852G>A",
"hgvs_p": "p.Arg951Gln",
"transcript": "ENST00000853738.1",
"protein_id": "ENSP00000523797.1",
"transcript_support_level": null,
"aa_start": 951,
"aa_end": null,
"aa_length": 1032,
"cds_start": 2852,
"cds_end": null,
"cds_length": 3099,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853738.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2828G>A",
"hgvs_p": "p.Arg943Gln",
"transcript": "ENST00000961719.1",
"protein_id": "ENSP00000631778.1",
"transcript_support_level": null,
"aa_start": 943,
"aa_end": null,
"aa_length": 1024,
"cds_start": 2828,
"cds_end": null,
"cds_length": 3075,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961719.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DAAM2",
"gene_hgnc_id": 18143,
"hgvs_c": "c.2660G>A",
"hgvs_p": "p.Arg887Gln",
"transcript": "ENST00000961718.1",
"protein_id": "ENSP00000631777.1",
"transcript_support_level": null,
"aa_start": 887,
"aa_end": null,
"aa_length": 968,
"cds_start": 2660,
"cds_end": null,
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}